Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sunil Deochand"'
Autor:
Ivy Tran, Alejandro Vargas, Reid Wilkins, Isabella Pizzillo, Kenneth Tokoro, Danielle Afterman, Tomer Lauterman, Maja Kuzman, Santiago Gonzalez, Dunja Glavas, James Smadbeck, Dillon Maloney, Jurica Levatic, Samuel Phillips, Sunil Deochand, Michael Yahalom, Ryan Ptashkin, Iman Tavassoly, Zohar Donenhirsh, Eric White, Ravi Kandasamy, Ury Alon, Paz Polak, Boris Oklander, Asaf Zviran, Matija Snuderl, Harvey I. Pass
Publikováno v:
Cancer Research. 83:6689-6689
Introduction: Lung cancer remains the leading cause of cancer-related deaths. Surgery is the best option for early lung cancer, and the role of adjuvant therapy remains controversial. Liquid biopsy offers a noninvasive approach to monitor cancer burd
Autor:
Ronan Chaligne, Alicia Alonso, Franco Izzo, Dana Silverbush, Alyssa R. Richman, Mario L. Suvà, Johanna Klughammer, Simon Gritsch, Jane Park, L. Nicolas Gonzalez Castro, Joshua S. Schiffman, Sunil Deochand, Orit Rozenblatt-Rosen, Aviv Regev, Tommaso Biancalani, Lloyd Kluegel, Christoph Muus, Dan A. Landau, Hannah R. Weisman, Federico Gaiti, Caroline Sheridan
Publikováno v:
Nat Genet
Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in cancer, often observed independently of genetic heterogeneity, raising the central question of how malignant cell states are encoded epigenetically. To address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c3528b1905f45f508edfae64363084
https://europepmc.org/articles/PMC8675181/
https://europepmc.org/articles/PMC8675181/
Autor:
Amanda Frydendahl, Thomas Reinert, Jesper Nors, Sunil Deochand, Dillon Maloney, Noah Friedman, Tomer Lauterman, Danielle Afterman, Imane Bourzgui, Nidhi Ramaraj, Zohar Donenhirsh, Ronel Veksler, Ravi Kandasamy, Iman Tavassoly, Jonathan Rosenfeld, Anders Husted Andersen, Uffe S. Løve, Per V. Andersen, Ole Thorlacius-Ussing, Lene Hjerrild Iversen, Kåre Andersson Gotschalck, Boris Oklander, Asaf Zviran, Claus Lindbjerg Andersen
Publikováno v:
Cancer Research. 82:1959-1959
Background: While detection of circulating tumor DNA (ctDNA) is associated with poor cancer prognosis, the clinical utility for guiding treatment decisions is unresolved. Patients with minimal residual disease (MRD) often have less than one genome eq
Autor:
Aaron C. Tan, Stephanie P. Saw, Gillianne G. Lai, Kevin L. Chua, Angela Takano, Boon-Hean Ong, Tina P. Koh, Amit Jain, Wan Ling Tan, Quan Sing Ng, Ravindran Kanesvaran, Tanujaa Rajasekaran, Sunil Deochand, Dillon Maloney, Danielle Afterman, Tomer Lauterman, Noah Friedman, Imane Bourzgui, Nidhi Ramaraj, Zohar Donenhirsh, Ronel Veksler, Jonathan Rosenfeld, Ravi Kandasamy, Iman Tavassoly, Boris Oklander, Asaf Zviran, Wan-Teck Lim, Eng-Huat Tan, Anders J. Skanderup, Mei-Kim Ang, Daniel S. Tan
Publikováno v:
Cancer Research. 82:5114-5114
Background: Early detection of recurrence and monitoring of MRD post-surgery is critical for clinical decision-making to tailor adjuvant therapy. In early-stage NSCLC, circulating tumor DNA (ctDNA) detection is especially challenging, requiring highl
Autor:
Ivy Tran, Kristyn Galbraith, Guisheng Zhao, Robyn Borsuk, Joyce Varkey, Sharon Gardner, Jeffrey Allen, David Harter, Jeffrey Wisoff, Eveline T. Hidalgo, Sunil Deochand, Dillon Maloney, Danielle Afterman, Tomer Lauterman, Noah Friedman, Imane Bourzgui, Nidhi Ramaraj, Zohar Donenhirsh, Ronel Veksler, Jonathan Rosenfeld, Ravi Kandasamy, Iman Tavassoly, Boris Oklander, G. Praveen Raju, Theodore Nicolaides, Asaf Zviran, Matija Snuderl
Publikováno v:
Cancer Research. 82:3401-3401
Introduction: Liquid biopsy offers a noninvasive approach to monitor cancer burden during therapy and surveillance period. However, in pediatric brain cancers, liquid biopsy methods from the blood have been unsuccessful due to a low tumor burden and
Autor:
Iver Nordentoft, Karin Birkenkamp-Demtröder, Emil Christensen, Sunil Deochand, Dillon Maloney, Danielle Afterman, Tomer Lauterman, Noah Friedman, Imane Bourzgui, Nidhi Ramaraj, Zohar Donenhirsh, Ronel Veksler, Sia Viborg, Mads Agerbæk, Jørgen Bjerggaard Jensen, Jonathan Rosenfeld, Ravi Kandasamy, Iman Tavassoly, Boris Oklander, Asaf Zviran, Lars Dyrskjøt
Publikováno v:
Cancer Research. 82:540-540
Background: Neoadjuvant chemotherapy (NAC) followed by radical cystectomy (CX), is gold standard treatment in localized muscle-invasive bladder cancer (MIBC). About 45% of patients with MIBC develop metastatic relapse within 2 years after CX. The res
Autor:
Ravi Kandasamy, Eric White, Joseph P. Strycharz, Sherry Hansen, Claude Hamby, Sarah Waterhouse, Ashley Salkeld, Kailyn Mannke, Cecille Valliere, Samuel Phillips, Nidhi Ramaraj, Christine Stanley, Uma Ananth, Sunil Deochand, Ronel Veksler, Tomer Lauterman, Danielle Afterman, Iman Tavassoly, Boris Oklander, Asaf Zviran
Publikováno v:
Journal of Clinical Oncology. 40:e13582-e13582
e13582 Background: Minimal residual disease (MRD) monitoring using liquid biopsy for solid tumors requires a highly sensitive and specific assay that can overcome the limitation of low abundance cfDNA in a standard blood draw. We developed a whole-ge
Autor:
Steven T. K. Hill, Rafael C. Schulman, Margaret K. Callahan, Patrick O. Bolan, Gavin Ha, Nicolas Robine, Sunil Deochand, Chelston Ang, Brian Houck-Loomis, Adam J. Widman, Asaf Zviran, Catherine F. Spinelli, Christian Stolte, Viktor A. Adalsteinsson, Alexi M. Runnels, Giorgio Inghirami, Sarah C. Reed, Federico Gaiti, Benchun Miao, Jedd D. Wolchok, Cole C. Khamnei, Nasser K. Altorki, Samantha Fennessey, Murtaza Malbari, Genevieve M. Boland, Will Liao, Dillon Maloney, Jennifer Ishii, Tatyana Sharova, Kevin Y. Huang, Kristofer Patel, Tommy Kim, Nathaniel D. Omans, Denisse Rotem, Dan A. Landau, Andrew Lipsky, Justin Rhoades, Selena Kazancioglu, Greg Gydush, Minita Shah, Phillip Wong, Dennie T. Frederick
Publikováno v:
Nat Med
In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a39e84c85ee6c6a61dd9d8a91de2d20
https://europepmc.org/articles/PMC8108131/
https://europepmc.org/articles/PMC8108131/
Autor:
Kyu-Tae Kim, Priscillia Lhoumaud, Rekha R. Murali, Ross L. Levine, Ephraim Kenigsberg, Baptiste Gross, Anna S. Nam, Federico Gaiti, Chelston Ang, Dan A. Landau, Stanley Chun-Wei Lee, Asaf Poran, Franco Izzo, Rafael C. Schulman, Steven Kothen-Hill, Philippa Wyndham Jones, Aaron D. Viny, Michelle Ki, Jane A. Skok, Omar Abdel-Wahab, Sunil Deochand, Ronan Chaligne
Publikováno v:
Nature Genetics
Nature genetics
Nature genetics
Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A) are frequently observed in hematological malignancies1–3 and clonal hematopoiesis4,5. Applying single-cell sequencing to murine hematopoietic stem and progenitor c
Autor:
Imane Bourzgui, Nidhi Ramaraj, Asaf Zviran, Ravi Kandasamy, Sia Viborg Lindskrog, Tomer Lauterman, Lars Dyrskjøt, Dillon Maloney, Emil Christensen, Mads Agerbæk, Iver Nordentoft, Kristofer Patel, Boris Oklander, Sunil Deochand, Karin Birkenkamp-Demtröder, Jørgen Bjerggaard Jensen, Iman Tavassoly
Publikováno v:
Journal of Clinical Oncology. 39:e16527-e16527
e16527 Background: Bladder cancer (BC) is the 9th most commonly diagnosed cancer worldwide and each year responsible for 165,000 deaths. Neoadjuvant combination chemotherapy, followed by radical cystectomy, is used for the management of localized mus