The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

Autor: Lakshmi Ganapathi, Simon Van Haren, David J Dowling, Ilana Bergelson, Nikunj M Shukla, Subbalakshmi S Malladi, Rajalakshmi Balakrishna, Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu, Sunil A David, Ofer Levy

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134640 (2015)

Newborns and young infants are at higher risk for infections than adults, and manifest suboptimal vaccine responses, motivating a search for novel immunomodulators and/or vaccine adjuvants effective in early life. In contrast to most TLR agonists (TL

Externí odkaz: https://doaj.org/article/696380fd21fe44ccb21fccde2a8a3ea0

Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis

Autor: Arshad Khan, Kangling Zhang, Vipul K. Singh, Abhishek Mishra, Priyanka Kachroo, Tian Bing, Jong Hak Won, Arunmani Mani, Ramesha Papanna, Lovepreet K. Mann, Eder Ledezma-Campos, Genesis Aguillon-Duran, David H. Canaday, Sunil A. David, Blanca I. Restrepo, Nhung Nguyen Viet, Ha Phan, Edward A. Graviss, James M. Musser, Deepak Kaushal, Marie Claire Gauduin, Chinnaswamy Jagannath

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)

Khan et al. use human blood and a macaque model of tuberculosis (TB) to assess whether macrophage heterogeneity contributes to TB immunity. They demonstrate that human macrophages show unique patterns of gene expression that enable differential contr

Externí odkaz: https://doaj.org/article/8cf06a1a4f1b42998d5b3586157a23de

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands

Autor: Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Ryota Sato, Nikunj M. Shukla, Sunil A. David, Toshiaki Isobe, Kensuke Miyake, Toshiyuki Shimizu

Publikováno v: Cell Reports, Vol 25, Iss 12, Pp 3371-3381.e5 (2018)

Summary: Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA (ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 shows synergistic activation in response to two ligands, guanosine and

Externí odkaz: https://doaj.org/article/375b181e186041cc9c1479bbedd8b5ba

Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine**

Autor: Angela Choi, Jana De Vrieze, Hamida Hammad, Florian Krammer, Kim Deswarte, Sunil A. David, Raveen Rathnasinghe, Niek N. Sanders, Sonia Jangra, Gabriel Laghlali, Fatima Amanat, Shirin Strohmeier, Simon Van Herck, Zifu Zhong, Bruno G. De Geest, Stefan Lienenklaus, Bart N. Lambrecht, Annemiek Uvyn, Lynda Coughlan, Michael Schotsaert, Lutz Nuhn, Adolfo García-Sastre

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(17), 9467-9473. John Wiley & Sons Ltd.

The search for vaccines that protect from severe morbidity and mortality because of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19) is a race against the clock and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc070b0f69ca8351821a57a8a6b946f
https://doi.org/10.1002/ange.202015362

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

Autor: Niek N. Sanders, Sunil A. David, Hans W. Scheeren, Yang Shi, Stefan Lienenklaus, Bart N. Lambrecht, Bi Wang, Kim Deswarte, Twan Lammers, Zifu Zhong, Xiangyang Bai, Simon Van Herck, Bruno G. De Geest, Fabian Kiessling, Yong Chen

Publikováno v: Journal of the American Chemical Society, 142(28), 12133-12139. American Chemical Society
Journal of the American Chemical Society
J Am Chem Soc

Synthetic immune-stimulatory drugs such as agonists of the Toll-like receptors (TLR) 7/8 are potent activators of antigen-presenting cells (APCs), however, they also induce severe side effects due to leakage from the site of injection into systemic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5692c8adef7fd362d5203ea34bc0c3
http://www.scopus.com/inward/record.url?scp=85088177240&partnerID=8YFLogxK