Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Sunil A. David"'
Autor:
Arshad Khan, Kangling Zhang, Vipul K. Singh, Abhishek Mishra, Priyanka Kachroo, Tian Bing, Jong Hak Won, Arunmani Mani, Ramesha Papanna, Lovepreet K. Mann, Eder Ledezma-Campos, Genesis Aguillon-Duran, David H. Canaday, Sunil A. David, Blanca I. Restrepo, Nhung Nguyen Viet, Ha Phan, Edward A. Graviss, James M. Musser, Deepak Kaushal, Marie Claire Gauduin, Chinnaswamy Jagannath
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
Khan et al. use human blood and a macaque model of tuberculosis (TB) to assess whether macrophage heterogeneity contributes to TB immunity. They demonstrate that human macrophages show unique patterns of gene expression that enable differential contr
Externí odkaz:
https://doaj.org/article/8cf06a1a4f1b42998d5b3586157a23de
Autor:
Claudio Counoupas, Paco Pino, Alberto O. Stella, Caroline Ashley, Hannah Lukeman, Nayan D. Bhattacharyya, Takuya Tada, Stephanie Anchisi, Charles Metayer, Jacopo Martinis, Anupriya Aggarwal, Belinda M. Dcosta, Warwick J. Britton, Joeri Kint, Maria J. Wurm, Nathaniel R. Landau, Megan Steain, Stuart G. Turville, Florian M. Wurm, Sunil A. David, James A. Triccas
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this report, we describe an adjuvanted subunit candidate vaccine that affords elevated, sust
Externí odkaz:
https://doaj.org/article/215dbedfcba04207b2b7b97f024ad384
Autor:
Alex C. D. Salyer, Sunil A. David
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 14, Iss 7, Pp 1686-1696 (2018)
An important component of vaccine development is the identification of safe and effective adjuvants. We sought to identify transcriptomal signatures of innate immune stimulating molecules using next-generation RNA sequencing with the goal of being ab
Externí odkaz:
https://doaj.org/article/47df89d90c6240fda6f3c3cb86264f5d
Autor:
Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Ryota Sato, Nikunj M. Shukla, Sunil A. David, Toshiaki Isobe, Kensuke Miyake, Toshiyuki Shimizu
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3371-3381.e5 (2018)
Summary: Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA (ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 shows synergistic activation in response to two ligands, guanosine and
Externí odkaz:
https://doaj.org/article/375b181e186041cc9c1479bbedd8b5ba
Autor:
Christian Czysch, Carolina Medina‐Montano, Zifu Zhong, Alexander Fuchs, Judith Stickdorn, Pia Winterwerber, Sascha Schmitt, Kim Deswarte, Marco Raabe, Maximilian Scherger, Francis Combes, Jana De Vrieze, Sabah Kasmi, Niek N. Sandners, Stefan Lienenklaus, Kaloian Koynov, Hans‐Joachim Räder, Bart N. Lambrecht, Sunil A. David, Matthias Bros, Hansjörg Schild, Stephan Grabbe, Bruno G. De Geest, Lutz Nuhn
Publikováno v:
Advanced Functional Materials, 32(35):2203490. Wiley-VCH
Advanced Functional Materials
Advanced Functional Materials
The development of controlled biodegradable materials is of fundamental importance in immunodrug delivery to spatiotemporally controlled immune stimulation but avoid systemic inflammatory side effects. Based on this, polycarbonate nanogels are develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acfb5007876972a84ea63a6bb0c2a2e
https://pure.eur.nl/en/publications/c2730e7e-773c-40fe-a341-123d74664982
https://pure.eur.nl/en/publications/c2730e7e-773c-40fe-a341-123d74664982
Autor:
Angela Choi, Jana De Vrieze, Hamida Hammad, Florian Krammer, Kim Deswarte, Sunil A. David, Raveen Rathnasinghe, Niek N. Sanders, Sonia Jangra, Gabriel Laghlali, Fatima Amanat, Shirin Strohmeier, Simon Van Herck, Zifu Zhong, Bruno G. De Geest, Stefan Lienenklaus, Bart N. Lambrecht, Annemiek Uvyn, Lynda Coughlan, Michael Schotsaert, Lutz Nuhn, Adolfo García-Sastre
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(17), 9467-9473. John Wiley & Sons Ltd.
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(17), 9467-9473. John Wiley & Sons Ltd.
The search for vaccines that protect from severe morbidity and mortality because of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19) is a race against the clock and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc070b0f69ca8351821a57a8a6b946f
https://doi.org/10.1002/ange.202015362
https://doi.org/10.1002/ange.202015362
Autor:
Alex C D Salyer, Giuseppe Caruso, Karishma K Khetani, Lauren M Fox, Subbalakshmi S Malladi, Sunil A David
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149848 (2016)
Small-molecule agonists have been identified for TLR7, TLR8, TLR4 and TLR2 thus far, and chemotypes other than those of canonical ligands are yet to be explored for a number of innate immune receptors. The discovery of novel immunostimulatory molecul
Externí odkaz:
https://doaj.org/article/fac84ee9b507428ca2994eb487d43eb8
Autor:
Yongjun Liu, Zifu Zhong, Simon Van Herck, Lutz Nuhn, Bruno G. De Geest, Niek N. Sanders, Francis Combes, Stefan Lienenklaus, Stefaan De Koker, Sunil A. David, Xiaochu Ding, Yadong Wang, Hui Li, Yanyun Hao, Zhiyue Zhang
Publikováno v:
ACS BIOMATERIALS SCIENCE & ENGINEERING
Strategies that can reduce the harmful side effects of potent immunomodulatory drugs are in high demand to facilitate clinical translation of the newest generation of immunotherapy. Indeed, uncontrolled triggering of the immune system can lead to lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c5c6b99d33f015a07dd3d03f0827cd
https://doi.org/10.1021/acsbiomaterials.0c00485
https://doi.org/10.1021/acsbiomaterials.0c00485
Autor:
Niek N. Sanders, Sunil A. David, Hans W. Scheeren, Yang Shi, Stefan Lienenklaus, Bart N. Lambrecht, Bi Wang, Kim Deswarte, Twan Lammers, Zifu Zhong, Xiangyang Bai, Simon Van Herck, Bruno G. De Geest, Fabian Kiessling, Yong Chen
Publikováno v:
Journal of the American Chemical Society, 142(28), 12133-12139. American Chemical Society
Journal of the American Chemical Society
J Am Chem Soc
Journal of the American Chemical Society
J Am Chem Soc
Synthetic immune-stimulatory drugs such as agonists of the Toll-like receptors (TLR) 7/8 are potent activators of antigen-presenting cells (APCs), however, they also induce severe side effects due to leakage from the site of injection into systemic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5692c8adef7fd362d5203ea34bc0c3
http://www.scopus.com/inward/record.url?scp=85088177240&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85088177240&partnerID=8YFLogxK
Autor:
Judith Stickdorn, Lara Stein, Danielle Arnold-Schild, Jennifer Hahlbrock, Carolina Medina-Montano, Joschka Bartneck, Tanja Ziß, Evelyn Montermann, Cinja Kappel, Dominika Hobernik, Maximilian Haist, Hajime Yurugi, Marco Raabe, Andreas Best, Krishnaraj Rajalingam, Markus P. Radsak, Sunil A. David, Kaloian Koynov, Matthias Bros, Stephan Grabbe, Hansjörg Schild, Lutz Nuhn
Publikováno v:
ACS Nano
The generation of specific humoral and cellular immune responses plays a pivotal role in the development of effective vaccines against tumors. Especially the presence of antigen-specific, cytotoxic T cells influences the outcome of therapeutic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9f646debac17e75bfa479e6d5a1492
https://pubmed.ncbi.nlm.nih.gov/35103463
https://pubmed.ncbi.nlm.nih.gov/35103463