Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sungyun Cho"'
Autor:
Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Mengying Hu, David Lyden, Wenbing Jin, Chunjun Guo, Noah Dephoure, Lewis C. Cantley, Ashley M. Laughney, John Blenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Methylmalonic acid (MMA) is increased in aging as well as produced by advanced tumors, and can drive pro-aggressive changes in these tumor cells. Here, the authors show that MMA can also act on fibroblasts in the tumor microenvironment, recruiting an
Externí odkaz:
https://doaj.org/article/f478066cc8a441dda1055be79d728377
Autor:
Kang Xu, Yannan Guo, Yida Wang, Yu Ren, Vivien Low, Sungyun Cho, Lu Ping, Kezheng Peng, Xue Li, Ying Qiu, Qingfei Liu, Zhongchi Li, Zhao Wang
Publikováno v:
Aging Cell. 22
Aging-associated microbial dysbiosis exacerbates various disorders and dysfunctions, and is a major contributor to morbidity and mortality in the elderly, but the underlying cause of this aging-related syndrome is confusing. SIRT6 knockout (SIRT6 KO)
Autor:
Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis
Publikováno v:
Science advances. 8(20)
Serine/one-carbon metabolism provides critical resources for nucleotide biosynthesis and epigenetic maintenance and is thus necessary in cancer cell growth, although the detailed regulatory mechanisms remain unclear. We uncover a critical role of gly
Autor:
Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Menying Hu, David Lyden, Wenbing Jin, Chun-Jun Guo, Noah Dephoure, Lewis Cantley, Ashley Laughney, John Blenis
The systemic metabolic shifts that occur during aging and the local metabolic alterations of a tumor, its stroma and their communication cooperate to establish a unique tumor microenvironment (TME) that fosters cancer progression. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9575aa72d5bb5e58a9b27e65aa970c0b
https://doi.org/10.21203/rs.3.rs-1643401/v1
https://doi.org/10.21203/rs.3.rs-1643401/v1
Autor:
Jinshun Su, Ruotan Zhang, Payman Dehghanian, Mohammad Heidari Kapourchali, Sungyun Choi, Zhaohao Ding
Publikováno v:
International Journal of Electrical Power & Energy Systems, Vol 159, Iss , Pp 110047- (2024)
The growing utilization of wind energy resources has been evidenced to have had substantial positive impacts on mitigating climate change consequences. Unlike stationary wind turbines, mobile wind turbines (MWTs) can travel along the local transporta
Externí odkaz:
https://doaj.org/article/e4b4dfacdf8041669e6b22527182296c
Autor:
John M. Asara, Jun Xu, Gina Lee, Chiwei Xu, Ah-Ram Kim, Cathleen Li, Hong-Wen Tang, John Blenis, Yanhui Hu, Richard Binari, Zhangfei Shen, Sungyun Cho, Norbert Perrimon, Jui-Hsia Weng, Wen Xing Lee, Min En Cheng, Lei Gu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 10
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Significance N6-methyladenosine (m 6 A) is the most prevalent modification in eukaryotic messenger RNA (mRNA) and affects RNA metabolism including splicing, stability, and translation. The m 6 A methyltransferase complex (MTC) is responsible for gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402a151653bef9807432db241cfa6551
https://escholarship.org/uc/item/7j09097s
https://escholarship.org/uc/item/7j09097s
Publikováno v:
Energies, Vol 17, Iss 17, p 4345 (2024)
In Korea, the demand for complete underground installation of power distribution equipment installed on roads and green areas is increasing. In addition, KEPCO is making efforts to build a more reliable system for the underground distribution system.
Externí odkaz:
https://doaj.org/article/57aa5d71f431459796e2bc9743755fd8
Autor:
Seung Soo Kim, John Blenis, Gina Lee, Brian F. Pickering, Sungyun Cho, Norbert Perrimon, Jin H. Park, Long He, Lavina Mathur, Cholsoon Jang, Samie R. Jaffrey, Hong-Wen Tang, Joshua D. Rabinowitz, Sunhee Jung, Sebastien Monette
Publikováno v:
Mol Cell
Molecular cell, vol 81, iss 10
Molecular cell, vol 81, iss 10
Dysregulated mTORC1 signaling alters a wide range of cellular processes, contributing to metabolic disorders and cancer. Defining the molecular details of downstream effectors is thus critical for uncovering selective therapeutic targets. We report t
Autor:
Gina Lee, Cholsoon Jang, Samie R. Jaffrey, Sungyun Cho, Joshua D. Rabinowitz, Brian F. Pickering, John Blenis
Publikováno v:
Molecular Cancer Research. 18:PR05-PR05
N6-adenosine methylation (m6A) is the most abundant chemical modification on eukaryotic mRNA. Emerging evidence shows that alterations in m6A modifications on mRNAs encoding oncogenes and tumor suppressors drive cancer initiation and progression incl
Autor:
Yuxiang Zheng, Gina Lee, Noah Dephoure, Sungyun Cho, Lew Cantley, Cholsoon Jang, John Blenis, Joshua D. Rabinowitz
Publikováno v:
Molecular Cancer Research. 18:IA12-IA12
The mTOR complex 1 (mTORC1)–S6 protein kinase (S6K1) signaling pathway has evolved to sense and respond to changes in growth factor and hormone-dependent signaling, cellular energy status, nutrient availability, and surrounding oxygen concentration