Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Sungsam Gong"'
Autor:
Sungsam Gong, Francesca Gaccioli, Irving L.M.H. Aye, Giulia Avellino, Emma Cook, Andrew R.J. Lawson, Luke M.R. Harvey, Gordon C.S. Smith, D. Stephen Charnock-Jones
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112800- (2023)
Summary: The human placenta exhibits a unique genomic architecture with an unexpectedly high mutation burden and many uniquely expressed genes. The aim of this study is to identify transcripts that are uniquely absent or depleted in the placenta. Her
Externí odkaz:
https://doaj.org/article/3db1e29e966546d3b16580f2785cba64
Autor:
Irving L. M. H. Aye, Sungsam Gong, Giulia Avellino, Roberta Barbagallo, Francesca Gaccioli, Benjamin J. Jenkins, Albert Koulman, Andrew J. Murray, D. Stephen Charnock-Jones, Gordon C. S. Smith
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Sex-dependent metabolism of spermine alter trophoblast gene expression through acetyl-coA biosynthesis and histone acetylation, indicating that escape of spermine synthase from X-linked inactivation partially contributes to placental sex differences.
Externí odkaz:
https://doaj.org/article/cdce78ca2527441a93b56d28ce2132f9
Autor:
Sungsam Gong, Francesca Gaccioli, Justyna Dopierala, Ulla Sovio, Emma Cook, Pieter-Jan Volders, Lennart Martens, Paul D. W. Kirk, Sylvia Richardson, Gordon C. S. Smith, D. Stephen Charnock-Jones
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Placental dysfunction can have catastrophic or barely discernible effects ranging from miscarriage to apparently normal birth. Here the authors present a comprehensive analysis of the human placental transcriptome and identify circular RNAs and piRNA
Externí odkaz:
https://doaj.org/article/78ea657a313c40d78515e1e336473167
Autor:
Sungsam Gong, Michelle D Johnson, Justyna Dopierala, Francesca Gaccioli, Ulla Sovio, Miguel Constância, Gordon CS Smith, D Stephen Charnock-Jones
Publikováno v:
Epigenetics, Vol 13, Iss 3, Pp 228-239 (2018)
DNA methylation is an important regulator of gene function. Fetal sex is associated with the risk of several specific pregnancy complications related to placental function. However, the association between fetal sex and placental DNA methylation rema
Externí odkaz:
https://doaj.org/article/84400fe7349e417db05abed1c84521a3
Autor:
D. Stephen Charnock-Jones, Pieter-Jan Volders, Sungsam Gong, Francesca Gaccioli, Lennart Martens, Gordon C. S. Smith, Emma Cook, Ulla Sovio, Paul D. W. Kirk, Justyna Dopierala, Sylvia Richardson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
NATURE COMMUNICATIONS
NATURE COMMUNICATIONS
Funder: Department of Health
The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term ill-health. The placenta is absent from most large-scale RNA-Seq datasets. We therefore analyze long a
The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term ill-health. The placenta is absent from most large-scale RNA-Seq datasets. We therefore analyze long a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00264fd7b5a463bc41ab6b3251c63767
https://doaj.org/article/78ea657a313c40d78515e1e336473167
https://doaj.org/article/78ea657a313c40d78515e1e336473167
Autor:
Francesca Gaccioli, Albert Koulman, Barbagallo R, Smith Gcs, Benjamin Jenkins, Aye Ilmh, Andrew J. Murray, D.S. Charnock-Jones, Sungsam Gong, Avellino G
Fetal sex differences play an important role in the pathophysiology of several placenta-related pregnancy complications. We previously reported that the maternal circulating level of a polyamine metabolite was altered in a fetal sex-specific manner,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b1fa5fab3bbd2b6c695c1d512944af1
https://doi.org/10.1101/2021.06.09.447192
https://doi.org/10.1101/2021.06.09.447192
Autor:
Ulla Sovio, Andrew M. Sharkey, Christian Delles, Julian Parkhill, Susanne Lager, Sharon J. Peacock, D. Stephen Charnock-Jones, Justyna Dopierala, Marcus C. de Goffau, Francesca Gaccioli, Gordon C. S. Smith, Sungsam Gong, Judith Breuer, Cristina Venturini, Ashley Moffett, Emma Cook, Wai K. Lee
Publikováno v:
Nature microbiology, 5(7), 901-908. Nature Publishing Group
Pre-eclampsia (typically characterized by new-onset hypertension and proteinuria in the second half of pregnancy) represents a major determinant of the global burden of disease1,2. Its pathophysiology involves placental dysfunction, but the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b7a54f6c3c092529a6fcd92540d52d
https://www.repository.cam.ac.uk/handle/1810/303646
https://www.repository.cam.ac.uk/handle/1810/303646
Autor:
Sungsam Gong, Tom L Blundell
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9186 (2010)
Human genetic variation is the incarnation of diverse evolutionary history, which reflects both selectively advantageous and selectively neutral change. In this study, we catalogue structural and functional features of proteins that restrain genetic
Externí odkaz:
https://doaj.org/article/4d5de055c2f443178ea2ed4fefae0166
Autor:
Sungsam Gong, Tom L Blundell
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 10, p e1000179 (2008)
Substitutions of individual amino acids in proteins may be under very different evolutionary restraints depending on their structural and functional roles. The Environment Specific Substitution Table (ESST) describes the pattern of substitutions in t
Externí odkaz:
https://doaj.org/article/a339f1d114594c75a6d700761401ae14
Autor:
Tom L. Blundell, Sungsam Gong
Publikováno v:
PLoS ONE; Vol 5
PLoS ONE
PLoS ONE, Vol 5, Iss 2, p e9186 (2010)
PLoS ONE
PLoS ONE, Vol 5, Iss 2, p e9186 (2010)
Human genetic variation is the incarnation of diverse evolutionary history, which reflects both selectively advantageous and selectively neutral change. In this study, we catalogue structural and functional features of proteins that restrain genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f1edadd0ac39045d217be78107d0a9