Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sunghee Chai"'
Autor:
Sunghee Chai, Leslie Wakefield, Mason Norgard, Bin Li, David Enicks, Daniel L. Marks, Markus Grompe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 504-512 (2023)
Significant progress has been made in developing recombinant adeno-associated virus (rAAV) for clinical gene therapy. While rAAV is a versatile gene delivery platform, its packaging limit of 4.7 kb limits the diseases it can target. Here, we report t
Externí odkaz:
https://doaj.org/article/c252d3e783894ccdac510a2d819e2d03
Autor:
Sunghee Chai, Youngjin Kim, Feorillo Galivo, Craig Dorrell, Leslie Wakefield, Jeffrey Posey, Amanda M. Ackermann, Klaus H. Kaestner, Matthias Hebrok, Markus Grompe
Publikováno v:
Human gene therapy. 33(15-16)
Diabetes mellitus, caused by loss or dysfunction of the insulin-producing beta cells of the pancreas, is a promising target for recombinant adeno-associated virus (rAAV)-mediated gene therapy. To target potential therapeutic payloads specifically to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53d5a4d0319373602e4d2bc21026e53
https://pubmed.ncbi.nlm.nih.gov/35297680
https://pubmed.ncbi.nlm.nih.gov/35297680
Publikováno v:
Proceedings of the National Academy of Sciences. 110:17898-17903
MicroRNA-134 (miR-134) serves as a widely accepted model for microRNA function in synaptic plasticity. In this model, synaptic activity stimulates miR-134 expression, which then regulates dendrite growth and spine formation. By using a ratiometric mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5abfc991ee1e1c0010ea2b9882bd017
https://doi.org/10.1073/pnas.1317528110
https://doi.org/10.1073/pnas.1317528110
Publikováno v:
Journal of Biological Chemistry. 285:13002-13011
Acid-sensing ion channels (ASICs) are voltage-independent Na(+) channels activated by extracellular protons. ASIC1a is expressed in neurons in mammalian brain and is implicated in long term potentiation of synaptic transmission that contributes to le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5d654815e42fee9556fcbb46c0b4be
https://doi.org/10.1074/jbc.m109.086041
https://doi.org/10.1074/jbc.m109.086041
Publikováno v:
Journal of Biological Chemistry. 282:22668-22677
Acid-sensing ion channel (ASIC) 1a and ASIC2a are acid-sensing ion channels in central and peripheral neurons. ASIC1a has been implicated in long-term potentiation of synaptic transmission and ischemic brain injury, whereas ASIC2a is involved in mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a19a108f2770b20ca29731068f883a
https://doi.org/10.1074/jbc.m703624200
https://doi.org/10.1074/jbc.m703624200
Publikováno v:
Journal of Bacteriology. 182:6762-6773
Products encoded in the trans -acting factor (TAF) region are necessary for the biosynthesis of anguibactin and for maximal expression of iron transport and biosynthesis genes in the plasmid-encoded iron-scavenging system of Vibrio anguillarum . Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4be7e61cb4d1c1b56e20f8e0e763e063
https://doi.org/10.1128/jb.182.23.6762-6773.2000
https://doi.org/10.1128/jb.182.23.6762-6773.2000
Publikováno v:
Journal of Biological Chemistry. 273:33841-33847
The expression of iron transport genes fatDCBA in Vibrio anguillarum strain 775 is negatively regulated by two iron-responsive repressors, the Fur protein and the antisense RNA, RNAalpha. Here we report the identification of the promoter for the iron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95092cca69763524bad9ca4ccc84e538
https://doi.org/10.1074/jbc.273.50.33841
https://doi.org/10.1074/jbc.273.50.33841
The complete nucleotide sequence and functional organization of Bacillus subtilis bacteriophage SPP1
Autor:
Sunghee Chai, Juan C. Alonso, Gerhild Lüder, Frank Weise, Asita C. Stiege, Thomas A. Trautner
Publikováno v:
Gene. 204:201-212
The complete nucleotide sequence of the B. subtilis bacteriophage SPP1 is described. The genome is 44 007 bp in size and has a base composition of 43.7% dG+dC. Only 32.2 kb are essential for phage amplification under laboratory conditions. Transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac6e0fd659ee6c313a57f1f38148afd
https://doi.org/10.1016/s0378-1119(97)00547-7
https://doi.org/10.1016/s0378-1119(97)00547-7
Publikováno v:
Journal of Molecular Biology. 270:50-64
Initiation of Bacillus subtilis bacteriophage SPP1 DNA replication requires the products of genes 38, 39 and 40 (G38P, G39P and G40P). G38P specifically binds two discrete regions, which are 32.1 kb apart in a linear map of the SPP1 genome. One of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d5a8567888b5ddb6115231b2cb2e20
https://doi.org/10.1006/jmbi.1997.1060
https://doi.org/10.1006/jmbi.1997.1060
Publikováno v:
Gene. 184:251-256
The B. subtilis bacteriophage SPP1 terminase, encoded by genes 1 and 2, is required for the initiation of headful packaging. The DNA segment to which gene 1 product (G1P) binds includes the pacL and pacR sites and the late PL1 and PL2 promoters from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388e3e10eb291a8ccab046ae7b18273c
https://doi.org/10.1016/s0378-1119(96)00609-9
https://doi.org/10.1016/s0378-1119(96)00609-9