Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Sungchul, Hohng"'
Autor:
Kyung-Won Min, Myung Hyun Jo, Minseok Song, Ji Won Lee, Min Ji Shim, Kyungmin Kim, Hyun Bong Park, Shinwon Ha, Hyejin Mun, Ahsan Polash, Markus Hafner, Jung-Hyun Cho, Dongsan Kim, Ji-Hoon Jeong, Seungbeom Ko, Sungchul Hohng, Sung-Ung Kang, Je-Hyun Yoon
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-15 (2024)
ABSTRACTAlthough Argonaute (AGO) proteins have been the focus of microRNA (miRNA) studies, we observed AGO-free mature miRNAs directly interacting with RNA-binding proteins, implying the sophisticated nature of fine-tuning gene regulation by miRNAs.
Externí odkaz:
https://doaj.org/article/2031b122a0b248eea1c5236fa50038ff
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-6 (2022)
The high-speed single-molecule miRNA detection technique dynamic FRET-FISH shows increased detection speed and high target specificity, detecting a single miRNA in ten seconds.
Externí odkaz:
https://doaj.org/article/a820953973b047e692c7aaf367afbd12
Autor:
Eunho Song, Heesoo Uhm, Palinda Ruvan Munasingha, Seungha Hwang, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Rho is a general transcription termination factor in bacteria. Here, Song et al. use single-molecule fluorescence assays to provide evidence that Rho-mediated transcription termination can occur via three kinetically different routes.
Externí odkaz:
https://doaj.org/article/b45db227dfd84b589754abd6da700e27
Publikováno v:
Biochemical Society Transactions; Apr2024, Vol. 52 Issue 2, p887-897, 11p
Autor:
Soochul Shin, Yoonseok Jung, Heesoo Uhm, Minseok Song, Soomin Son, Jiyoung Goo, Cherlhyun Jeong, Ji-Joon Song, V. Narry Kim, Sungchul Hohng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
MicroRNAs are potentially powerful biomarkers, though clinical use requires rapid and reliable profiling. Here the authors report amplification-free multicolour single-molecule imaging with single base mismatch sensitivity.
Externí odkaz:
https://doaj.org/article/a1f97de236b54183ad3bf6dbebd4a004
Autor:
Wooyoung Kang, Kook Sun Ha, Heesoo Uhm, Kyuhyong Park, Ja Yil Lee, Sungchul Hohng, Changwon Kang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Bacterial transcription is terminated when RNA polymerases encounter terminator sequences. Using a single-molecule fluorescence assay, here the authors show that the release of transcript RNA precedes RNA polymerase dissociation and that the remainin
Externí odkaz:
https://doaj.org/article/d97e30411e7f425eab5086b9c09f7d1c
Autor:
Su Hyung Park, Nalae Kang, Eunho Song, Minwoo Wie, Eun A. Lee, Sunyoung Hwang, Deokjae Lee, Jae Sun Ra, In Bae Park, Jieun Park, Sukhyun Kang, Jun Hong Park, Sungchul Hohng, Kyoo-young Lee, Kyungjae Myung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD
Externí odkaz:
https://doaj.org/article/4ac4913c149c4dd78292e37f24a832b8
Autor:
Gunhyoung Lim, Sungchul Hohng
Publikováno v:
Bio-Protocol, Vol 11, Iss 13 (2021)
G-quadruplexes (GQ) and R-loops are non-canonical nucleic acid structures related to gene regulation and genome instability that can be formed during transcription; however, their formation mechanisms remain elusive. To address this question, we deve
Externí odkaz:
https://doaj.org/article/87928a43c08e4a0588250da376fbdb4b
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Recent development of FRET-PAINT microscopy significantly improved the imaging speed of DNA-PAINT, the previously reported super-resolution fluorescence microscopy with no photobleaching problem. Here we try to achieve the ultimate speed lim
Externí odkaz:
https://doaj.org/article/4de9582588b34c40b63b292e730257be
Transcriptional pause extension benefits the stand-by rather than catch-up Rho-dependent termination
Autor:
Eunho Song, Seungha Hwang, Palinda Ruvan Munasingha, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Publikováno v:
Nucleic Acids Research. 51:2778-2789
Transcriptional pause is essential for all types of termination. In this single-molecule study on bacterial Rho factor-dependent terminators, we confirm that the three Rho-dependent termination routes operate compatibly together in a single terminato