Zobrazeno 1 - 10
of 112
pro vyhledávání: '"SungSoon Fang"'
Publikováno v:
Diabetes & Metabolism Journal, Vol 48, Iss 5, Pp 901-914 (2024)
Background Diacylglycerol O-acyltransferase 2 (DGAT2) synthesizes triacylglycerol (TG) from diacylglycerol; therefore, DGAT2 is considered as a therapeutic target for steatosis. However, the consequence of inhibiting DGAT2 is not fully investigated d
Externí odkaz:
https://doaj.org/article/bd084089d76f490c8a671ff542018d4b
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 7, Pp 1513-1522 (2024)
Abstract Serine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal proliferation and stress in cance
Externí odkaz:
https://doaj.org/article/ac82ea2814654f08ace9e8d11430684b
Autor:
Jeong-Yun Lee, Suhyeon Park, Eun Jung Park, Haushabhau S. Pagire, Suvarna H. Pagire, Byeong-Wook Choi, Moonyoung Park, Sungsoon Fang, Jin Hee Ahn, Chang-Myung Oh
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117428- (2024)
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Serotonin (5-HT) is a biogenic monoamine that acts as a neurotransmitter in the central nervous system and as a paracrine, exocrine, or endocrine messenger in periphera
Externí odkaz:
https://doaj.org/article/3c6e1e5bb9bd421ba99a5c76ad1f25ea
Autor:
Seyeon Joo, Sungsoon Fang
Publikováno v:
Gut and Liver, Vol 18, Iss 3, Pp 365-367 (2024)
Externí odkaz:
https://doaj.org/article/28e893128eef47c8be2a827a82358e2e
Autor:
Chae Min Lee, Yeseong Hwang, Jae Woong Jeong, Minki Kim, Janghee Lee, Soong June Bae, Sung Gwe Ahn, Sungsoon Fang
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with inferior outcomes owing to its low treatment response and high invasiveness. Based on abundant cancer-associated fibroblasts (CAFs) and frequent mutation of bre
Externí odkaz:
https://doaj.org/article/8b992212685543c3abd95aa3b7f177e2
Autor:
Chae Min Lee, Sungsoon Fang
Publikováno v:
Journal of Obesity & Metabolic Syndrome, Vol 32, Iss 4, Pp 312-321 (2023)
Obesity, now officially recognized as a disease requiring intervention, has emerged as a significant health concern due to its strong association with elevated susceptibility to diverse diseases and various types of cancer, including breast cancer. T
Externí odkaz:
https://doaj.org/article/13741e5cb1eb4f9d90cf7fd255152317
Autor:
Nahee Hwang, Bo Kyung Yoon, Kyu-Hye Chun, Hyeonhui Kim, Yoseob Lee, Jae-Won Kim, Hyeonuk Jeon, Tae-Hyun Kim, Mi-Young Kim, Sungsoon Fang, Jae-Ho Cheong, Jae-woo Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 11, Pp 2461-2472 (2023)
Abstract Despite advances in cancer therapy, the clinical outcome of patients with gastric cancer remains poor, largely due to tumor heterogeneity. Thus, finding a hidden vulnerability of clinically refractory subtypes of gastric cancer is crucial. H
Externí odkaz:
https://doaj.org/article/b65ea5c8df254d1bb12e30fa0b8f7f3f
Autor:
Jongsu Jeon, Dohyun Lee, Bobae Kim, Bo-Yoon Park, Chang Joo Oh, Min-Ji Kim, Jae-Han Jeon, In-Kyu Lee, Onyu Park, Seoyeong Baek, Chae Won Lim, Dongryeol Ryu, Sungsoon Fang, Johan Auwerx, Kyong-Tai Kim, Hoe-Yune Jung
Publikováno v:
Diabetes & Metabolism Journal, Vol 47, Iss 5, Pp 653-667 (2023)
Background CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated. Methods KK-Ay mice, a type 2 diabetes mellitus (T2DM) model, were administered CycloZ either as a prev
Externí odkaz:
https://doaj.org/article/91fb5259262c4b9db1117c6fff669cf2
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Immune checkpoint inhibitors (ICIs) are promising agents for treating melanoma. Given that autoimmune skin diseases exhibit hyper immune reaction, investigation of immune cells from autoimmune skin disease is crucial to validate the effectiv
Externí odkaz:
https://doaj.org/article/a080563f36504406874a78f1e8747f5b
Autor:
Yeseong Hwang, Hyeok Jun Yun, Jae Woong Jeong, Minki Kim, Seyeon Joo, Hae-Kyung Lee, Hang-Seok Chang, Seok-Mo Kim, Sungsoon Fang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-17 (2023)
Abstract Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors with an extremely poor prognosis. Based on the several biological features related to glutamine metabolism in ATC, we hypothesized glutaminolysis inhibition induces cell de
Externí odkaz:
https://doaj.org/article/2337715684084b72a8b6c4c29227908a