Zobrazeno 1 - 10
of 35
pro vyhledávání: '"SungMin Nam"'
Autor:
Joanna Y. Lee, Jessica K. Chang, Antonia A. Dominguez, Hong-pyo Lee, Sungmin Nam, Julie Chang, Sushama Varma, Lei S. Qi, Robert B. West, Ovijit Chaudhuri
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The transcriptional regulator YAP is regarded as the universal mechanotransducer, largely from 2D culture studies. Here the authors show that in breast cancer patient tissues and cells in 3D culture, mechanical signals are transduced independently of
Externí odkaz:
https://doaj.org/article/337f109f64fc4a38a5a3689ef568e48a
Publikováno v:
Advanced Science, Vol 8, Iss 4, Pp n/a-n/a (2021)
Abstract Cell elongation along the division axis, or mitotic elongation, mediates proper segregation of chromosomes and other intracellular materials, and is required for completion of cell division. In three‐dimensionally confining extracellular m
Externí odkaz:
https://doaj.org/article/680fd3c88b39481e90ce50e2fa2ac8bd
Autor:
Katrina M. Wisdom, Kolade Adebowale, Julie Chang, Joanna Y. Lee, Sungmin Nam, Rajiv Desai, Ninna Struck Rossen, Marjan Rafat, Robert B. West, Louis Hodgson, Ovijit Chaudhuri
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In order to metastasize, cancer cells must migrate through basement membranes and dense stroma, and proteases are thought to be required due to the confining nature of these matrices. Here the authors use synthetic matrices to show that cells can mig
Externí odkaz:
https://doaj.org/article/98c929b92b67496b9f803a21d27ece3c
Publikováno v:
Nature Materials. 22:249-259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b579f044054ef30648e784d7caf430
https://doi.org/10.1038/s41563-022-01396-x
https://doi.org/10.1038/s41563-022-01396-x
Autor:
Benjamin R. Freedman, Andreas Kuttler, Nicolau Beckmann, Sungmin Nam, Daniel Kent, Michael Schuleit, Farshad Ramazani, Nathalie Accart, Anna Rock, Jianyu Li, Markus Kurz, Andreas Fisch, Thomas Ullrich, Michael W. Hast, Yann Tinguely, Eckhard Weber, David J. Mooney
Publikováno v:
Nature Biomedical Engineering. 6:1167-1179
Hydrogels that provide mechanical support and sustainably release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276904731ef61f38d8dd5d1aa481e7ae
https://doi.org/10.1038/s41551-021-00810-0
https://doi.org/10.1038/s41551-021-00810-0
Autor:
Stephanie L. McNamara, Irene de Lázaro, David J. Mooney, Max Darnell, Conor J. Walsh, Bo Ri Seo, Sungmin Nam, Benjamin R. Freedman, Jonathan T. Alvarez, Herman H. Vandenburgh, Maxence O. Dellacherie, Brian J. Kwee, Christopher J. Payne
Publikováno v:
Sci Transl Med
Mechanical stimulation (mechanotherapy) can promote skeletal muscle repair, but a lack of reproducible protocols and mechanistic understanding of the relation between mechanical cues and tissue regeneration limit progress in this field. To address th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d435f4febdeba08ebc484fa4a15d88
https://pubmed.ncbi.nlm.nih.gov/34613813
https://pubmed.ncbi.nlm.nih.gov/34613813
Autor:
Joanna Y. Lee, Ovijit Chaudhuri, Ryan S. Stowers, Lei S. Qi, Sungmin Nam, Antonia A. Dominguez
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific reports, vol 9, iss 1
Scientific reports, vol 9, iss 1
Yes-associated protein (YAP) is a transcriptional regulator and mechanotransducer, relaying extracellular matrix (ECM) stiffness into proliferative gene expression in 2D culture. Previous studies show that YAP activation is dependent on F-actin stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a881a88984fac0af4c4bdc9a8c7dbc
http://link.springer.com/article/10.1038/s41598-019-53659-4
http://link.springer.com/article/10.1038/s41598-019-53659-4
Autor:
Julie Chang, Ryan S. Stowers, Atefeh Rabiee, Mary N. Teruel, Anna Shcherbina, Ovijit Chaudhuri, Joshua J. Gruber, Michael Snyder, Anshul Kundaje, Johnny Israeli, Sungmin Nam
Publikováno v:
Nature biomedical engineering
Nature biomedical engineering, vol 3, iss 12
Nature biomedical engineering, vol 3, iss 12
In breast cancer, the increased stiffness of the extracellular matrix is a key driver of malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic impact of extracellular matrix mechanics. Here, we show in a three-dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5c3788f8fd74de4c22dbfd2039750f
https://doi.org/10.1038/s41551-019-0420-5
https://doi.org/10.1038/s41551-019-0420-5
Autor:
Vivek K. Gupta, Judy Lisette Martin, Adam C. Martin, Jaclyn Camuglia, Ovijit Chaudhuri, Sungmin Nam, Donghyun Yim, Lucy Erin O'Brien, Taeyoon Kim, Erin Sanders
Publikováno v:
Rockefeller University Press
The Journal of Cell Biology
The Journal of Cell Biology
Gupta et al. investigate forces generated during cell division in confining epithelial monolayers. In addition to finding that cells generate forces during mitotic rounding, they find that cells generate protrusive forces along the division axis that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca58435b068b6667828f699d19facd0
https://doi.org/10.1083/jcb.202011106
https://doi.org/10.1083/jcb.202011106
Publikováno v:
Nature materials.
While mechanical stimulation is known to regulate a wide range of biological processes at the cellular and tissue levels, its medical use for tissue regeneration and rehabilitation has been limited by the availability of suitable devices. Here we pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0dff8a9869f4337a76d61ef7d8f5cf4
https://pubmed.ncbi.nlm.nih.gov/36357687
https://pubmed.ncbi.nlm.nih.gov/36357687