Zobrazeno 1 - 10 of 95 pro vyhledávání: '"Sung-Ouk Kim"'
1
Akademický článek
Prolonged Inhibition of the MEK1/2-ERK Signaling Axis Primes Interleukin-1 Beta Expression through Histone 3 Lysine 9 Demethylation in Murine Macrophages
Autor: Rachel Low, Soon-Duck Ha, Nichita Sleapnicov, Parthiv Maneesh, Sung Ouk Kim
Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 19, p 14428 (2023)
Macrophages undergo different cellular states upon activation that can be hyporesponsive (tolerated) or hyperresponsive (primed or trained) to subsequent stimuli. Epigenetic modifications are known to play key roles in determining these cellular stat
Externí odkaz: https://doaj.org/article/6b71714cc7fb4feba5f8febd5ee5a4d4
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2
Akademický článek
Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity
Autor: Soon-Duck Ha, Ori Solomon, Masoud Akbari, Alp Sener, Sung Ouk Kim
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Cell death by hypoxia followed by reoxygenation (H/R) is responsible for tissue injury in multiple pathological conditions. Recent studies found that epigenetic reprogramming mediated by histone deacetylases (HDACs) is implicated in H/R-indu
Externí odkaz: https://doaj.org/article/c65d5d5d660f401b9720461a75826af9
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3
Akademický článek
HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells
Autor: Soon-Duck Ha, Naomi Lewin, Shawn S. C. Li, Sung-Ouk Kim
Publikováno v: Cells, Vol 10, Iss 5, p 1101 (2021)
Inhibition of the RAF-MEK1/2-ERK signaling pathway is an ideal strategy for treating cancers with NRAS or BRAF mutations. However, the development of resistance due to incomplete inhibition of the pathway and activation of compensatory cell prolifera
Externí odkaz: https://doaj.org/article/60d7606b37474f448c7f775478089539
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6
Akademický článek
p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization.
Autor: Sangwook Park, Soon-Duck Ha, Macon Coleman, Shahab Meshkibaf, Sung Ouk Kim
Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57138 (2013)
NOD2 is a cytosolic pattern-recognition receptor that senses muramyl dipeptide of peptidoglycan that constitutes the bacterial cell wall, and plays an important role in maintaining immunological homeostasis in the intestine. To date, multiple molecul
Externí odkaz: https://doaj.org/article/498675ed3bb14d24be42fed03f00efce
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7
Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity
Autor: Alp Sener, Soon-Duck Ha, Ori Solomon, Sung Ouk Kim, Masoud Akbari
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Anatomy and Cell Biology Publications
Scientific Reports
Cell death by hypoxia followed by reoxygenation (H/R) is responsible for tissue injury in multiple pathological conditions. Recent studies found that epigenetic reprogramming mediated by histone deacetylases (HDACs) is implicated in H/R-induced cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669a321a39c287d3dde50f141cfae160
https://doaj.org/article/c65d5d5d660f401b9720461a75826af9
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8
Effect of Lactobacillus rhamnosus GR-I Supernatant on Cytokine and Chemokine Output From Human Amnion Cells Treated With Lipoteichoic Acid and Lipopolysaccharide
Autor: Gregor Reid, John R. G. Challis, Alan D. Bocking, Rebecca J E Koscik, Wei Li, Sung Ouk Kim
Publikováno v: Reproductive Sciences. 25:239-245
Preterm birth occurs in 9% to 13% of all human pregnancies and accounts for 80% of all neonatal morbidities and mortalities. Approximately 40% of all preterm births are idiopathic and about half are associated with infection and/or an activated infla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::222db793310fd0729ace50d6f2edee26
https://doi.org/10.1177/1933719117711259
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10
The transcription factor PU.1 mediates enhancer-promoter looping that is required for IL-1β eRNA and mRNA transcription in mouse melanoma and macrophage cell lines
Autor: Sung Ouk Kim, Soon-Duck Ha, Rodney P. DeKoter, Woohyun Cho
Publikováno v: Paediatrics Publications
J Biol Chem
The DNA-binding protein PU.1 is a myeloid lineage–determining and pioneering transcription factor due to its ability to bind "closed" genomic sites and maintain "open" chromatin state for myeloid lineage–specific genes. The precise mechanism of P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651d68670779c2598a232572b7b79cab
https://ir.lib.uwo.ca/paedpub/1092
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