Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sung-Jae Cha"'
Autor:
Marcelo Jacobs-Lorena, Sung-Jae Cha
Publikováno v:
Emerging Microbes and Infections (2024)
Malaria is among the deadliest infectious diseases. Over 200 million annual clinical malaria cases are reported and more than half a million people, mostly children, die every year. The most advanced RTS,S/AS01 vaccine based on the P. falciparum circ
Externí odkaz:
https://doaj.org/article/e30304767ca24b1eb265a1f99fc7412a
Autor:
Min Kyu Sang, Hongray Howrelia Patnaik, Jie Eun Park, Dae Kwon Song, Jun Yang Jeong, Chan Eui Hong, Yong Tae Kim, Hyeon Jun Shin, Liu Ziwei, Hee Ju Hwang, So Young Park, Se Won Kang, Seung-Hwan Park, Sung-Jae Cha, Jung Ho Ko, E. Hyun Shin, Hong Seog Park, Yong Hun Jo, Yeon Soo Han, Bharat Bhusan Patnaik, Yong Seok Lee
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-18 (2023)
Abstract Background Ticks are ectoparasites capable of directly damaging their hosts and transmitting vector-borne diseases. The ixodid tick Haemaphysalis flava has a broad distribution that extends from East to South Asia. This tick is a reservoir o
Externí odkaz:
https://doaj.org/article/3b1547dce26248d4996db230eeeea9a3
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionLeishmaniasis comprises a complex group of diseases caused by protozoan parasites from the Leishmania genus, presenting a significant threat to human health. Infection starts by the release into the skin of metacyclic promastigote (MP) fo
Externí odkaz:
https://doaj.org/article/78acb6cea7c8431aa3719f91dcfa4eb7
Autor:
Sung-Jae Cha, Joel Vega-Rodriguez, Dingyin Tao, Heather M. Kudyba, Kelly Hanner, Marcelo Jacobs-Lorena
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Plasmodium fertilization, an essential step for the development of the malaria parasite in the mosquito, is a prime target for blocking pathogen transmission. Using phage peptide display screening, we identified MG1, a peptide that binds to
Externí odkaz:
https://doaj.org/article/db04b044c8dc4d22bde02b008c644950
Publikováno v:
Vaccines, Vol 12, Iss 5, p 484 (2024)
The WHO reported an estimated 249 million malaria cases and 608,000 malaria deaths in 85 countries in 2022. A total of 94% of malaria deaths occurred in Africa, 80% of which were children under 5. In other words, one child dies every minute from mala
Externí odkaz:
https://doaj.org/article/e846ae60d3d2495e8b68fcc7fa809085
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
After transmission of Plasmodium sporozoites from infected mosquitoes, parasites first infect hepatocytes. Here, Cha et al. identify a sporozoite ligand (phospholipid scramblase) and the hepatocytic receptor (carbamoyl-phosphate synthetase 1) as rele
Externí odkaz:
https://doaj.org/article/d8ed248f9c5e47a38f04d306b2a1b9da
Publikováno v:
eLife, Vol 11 (2022)
Malaria is among the deadliest infectious diseases, and Plasmodium, the causative agent, needs to complete a complex development cycle in its vector mosquito for transmission to occur. Two promising strategies to curb transmission are transgenesis, c
Externí odkaz:
https://doaj.org/article/fcda4b9d09394aa9bc8dc61348f201ce
Autor:
Jéssica I. de Paula, Eduardo J. Lopes-Torres, Marcelo Jacobs-Lorena, Marcia Cristina Paes, Sung-Jae Cha
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
BackgroundChagas is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. On the order of seven million people are infected worldwide and current therapies are limited, highlighting the urgent need for new interventions. T.
Externí odkaz:
https://doaj.org/article/088f19629e7a45f5ae33320dbf86cd5a
Autor:
Sung-Jae Cha, Xiang Yu, Brian D. Gregory, Yong Seok Lee, Tomoko Ishino, Robert O. Opoka, Chandy C. John, Marcelo Jacobs-Lorena
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood. Here we report on the identificat
Externí odkaz:
https://doaj.org/article/55981d5b5a3d405c8e8c14cc1be98e6b
Apolipophorin-III mediates antiplasmodial epithelial responses in Anopheles gambiae (G3) mosquitoes.
Autor:
Lalita Gupta, Ju Young Noh, Yong Hun Jo, Seung Han Oh, Sanjeev Kumar, Mi Young Noh, Yong Seok Lee, Sung-Jae Cha, Sook Jae Seo, Iksoo Kim, Yeon Soo Han, Carolina Barillas-Mury
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15410 (2010)
Apolipophorin-III (ApoLp-III) is known to play an important role in lipid transport and innate immunity in lepidopteran insects. However, there is no evidence of involvement of ApoLp-IIIs in the immune responses of dipteran insects such as Drosophila
Externí odkaz:
https://doaj.org/article/e0292bf7c45a44aaa1500a73e1ba099b