Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sung-Ik Cho"'
Autor:
Jaesuk Lee, Kayeong Lim, Annie Kim, Young Geun Mok, Eugene Chung, Sung-Ik Cho, Ji Min Lee, Jin-Soo Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Cas9 nickases (nCas9s) produce nicks or single-strand breaks in the DNA. Here the authors analyse the on- and off-target nicks generated by these nickases, and show that nCas9 (H840A) but not nCas9 (D10A) can cleave both strands and produce unwanted
Externí odkaz:
https://doaj.org/article/d4e6a4c2bb8349c89d41ddb7631ab4af
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Monomeric DdCBEs (mDdCBEs), enabling mitochondrial DNA editing with high efficiencies of up to 50%, when transiently expressed in cultured human cells and nearly homoplasmic C-to-T editing via AAV.
Externí odkaz:
https://doaj.org/article/217dabfa7f04465aa29214433432d07a
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Base editing in nuclear DNA and mitochondrial DNA (mtDNA) is broadly useful for biomedical research, medicine, and biotechnology. Here the authors present zinc finger deaminases which catalyze targeted C-to-T base conversions without inducing unwante
Externí odkaz:
https://doaj.org/article/b953e7a175d541f19ce765ed3b4a5318
Autor:
Sung-Ik Cho, Young-Sik Park, Jang-Hyun Park, Yong-Ho Lee, Sang-Kil Lee, Sug-Whan Kim, Wonyoung Han
Publikováno v:
Journal of Astronomy and Space Sciences, Vol 21, Iss 4, Pp 481-492 (2004)
We report the successful fabrication and I--V curve superconductivity test results of the Nb/Al-based superconducting tunnel junctions. STJs with side-lengths of 20, 40, 60 and 80 μm were fabricated by deposition of polycrystalline Nb/Al/AlOx/Al/Nb
Externí odkaz:
https://doaj.org/article/eb665d10e23d44be8332116731c8d819
Publikováno v:
Nature Plants. 8:1378-1384
Chloroplast DNA (cpDNA) encodes up to 315 (typically, 120–130) genes1, including those for essential components in photosystems I and II and the large subunit of RuBisCo, which catalyses CO2 fixation in plants. Targeted mutagenesis in cpDNA will be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b0acb5ddf69a9658badc07e610777c
https://doi.org/10.1038/s41477-022-01279-8
https://doi.org/10.1038/s41477-022-01279-8
Autor:
Jaesuk Lee, Kayeong Lim, Annie Kim, Young Geun Mok, Eugene Chung, Sung-Ik Cho, Ji Min Lee, Jin-Soo Kim
Unlike CRISPR-Cas9 nucleases, which yield DNA double-strand breaks (DSBs), Cas9 nickases (nCas9s), which are created by replacing key catalytic amino-acid residues in one of the two nuclease domains of S. pyogenesis Cas9 (SpCas9), produce nicks or si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d074bb2c224754fe6dbb1b86508a0a41
https://doi.org/10.21203/rs.3.rs-2236723/v1
https://doi.org/10.21203/rs.3.rs-2236723/v1
Publikováno v:
Journal of Korean Society of Geriatric Neurosurgery. 16:42-46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf42663660911cc7d4c08985a363dd8f
https://doi.org/10.51638/jksgn.20.00297
https://doi.org/10.51638/jksgn.20.00297
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
This study assessed the pupil responses in the sensory integration of various directional optic flows during the perception of gravitational vertical. A total of 30 healthy participants were enrolled with normal responses to conventional subjective v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35c16122206d55f644854604394949c
https://doi.org/10.1038/s41598-021-00346-y
https://doi.org/10.1038/s41598-021-00346-y
Publikováno v:
Nature Biotechnology. 37:430-435
Adenine base editors1 enable efficient targeted adenine-to-guanine single nucleotide conversions to induce or correct point mutations in human cells, animals, and plants1–4. Here we present a modified version of Digenome-seq, an in vitro method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::572fd3bab1f3133487004e8bf52df63d
https://doi.org/10.1038/s41587-019-0050-1
https://doi.org/10.1038/s41587-019-0050-1
Autor:
Baisong Lu, Kyung Whan Yoo, Sung-Ik Cho, Anthony Atala, Zuyan Lu, Manish Kumar Yadav, Jin-Soo Kim, Pin Lyu
Publikováno v:
The CRISPR journal. 4(1)
Adenine base editors (ABEs) can correct gene mutations without creating double-strand breaks. However, in recent reports, these editors showed guide-independent RNA off-target activities. This work describes our development of a delivery method to mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa567ac3693405da565e70927e65fafe
https://pubmed.ncbi.nlm.nih.gov/33616436
https://pubmed.ncbi.nlm.nih.gov/33616436