Zobrazeno 1 - 10
of 497
pro vyhledávání: '"Sung-Ho Ryu"'
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 10, Pp 2147-2161 (2023)
Abstract The binding of insulin to the insulin receptor (IR) triggers a cascade of receptor conformational changes and autophosphorylation, leading to the activation of metabolic and mitogenic pathways. Recent advances in the structural and functiona
Externí odkaz:
https://doaj.org/article/f7dba2f20683470bbfe83921bbe9b480
Autor:
Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung, Yunje Cho
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.
Externí odkaz:
https://doaj.org/article/3a702a1ed24a45f995d55ea263c1b376
Autor:
Junhong Kim, Na-Oh Yunn, Mangeun Park, Jihan Kim, Seongeun Park, Yoojoong Kim, Jeongeun Noh, Sung Ho Ryu, Yunje Cho
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
DNA aptamers can activate insulin receptor as selective agonists or positive allosteric modulators. Here, authors determine structures of the insulin receptor bound to aptamers and provide a basis for the selective activation or allosteric regulation
Externí odkaz:
https://doaj.org/article/0f9ef9c7c1154aaf96d63a9da999e2bb
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 8, Pp 1-9 (2018)
Gut health: intestinal barrier function underpins health and disease A better understanding of how the cells that line the inside of the intestines allow nutrients in, while keeping harmful substances and pathogens out could lead to new therapies for
Externí odkaz:
https://doaj.org/article/ec2bf7c57817483e9637780c9919790a
Autor:
Soyeon Park, Ji-Hwan Park, Hee-Jung Jung, Jin-Hyeok Jang, Sanghyun Ahn, Younah Kim, Pann-Ghill Suh, Sehyun Chae, Jong Hyuk Yoon, Sung Ho Ryu, Daehee Hwang
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 8, Pp 1-14 (2018)
Cancer: secreted proteins associated with fat-induced tumor growth By exposing liver cancer cells to oleate, an unsaturated fatty acid, researchers have discovered a group of secreted proteins that may help explain why fatty acids increase proliferat
Externí odkaz:
https://doaj.org/article/92b0d9c45dd2421abdcdf493fb326f0c
Publikováno v:
ACS Central Science, Vol 4, Iss 5, Pp 614-623 (2018)
Externí odkaz:
https://doaj.org/article/1e86f6b91ec84c71a5302a035754cbf9
Autor:
Hoe-Yune Jung, Dongyeop Lee, Hye Guk Ryu, Bo-Hwa Choi, Younghoon Go, Namgyu Lee, Dohyun Lee, Heehwa G. Son, Jongsu Jeon, Seong-Hoon Kim, Jong Hyuk Yoon, Seon-Min Park, Seung-Jae V. Lee, In-Kyu Lee, Kwan Yong Choi, Sung Ho Ryu, Kazunari Nohara, Seung-Hee Yoo, Zheng Chen, Kyong-Tai Kim
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested wh
Externí odkaz:
https://doaj.org/article/10201d00788242438ead92d92999e6dd
Autor:
Chaithanya Chelakkot, Jaewang Ghim, Nirmal Rajasekaran, Jong-Sun Choi, Jung-Hwan Kim, Myoung Ho Jang, Young Kee Shin, Pann-Ghill Suh, Sung Ho Ryu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Ulcerative colitis is a multi-factorial disease involving a dysregulated immune response. Disruptions to the intestinal epithelial barrier and translocation of bacteria, resulting in inflammation, are common in colitis. The mechanisms underl
Externí odkaz:
https://doaj.org/article/e627bc7f4f0645b6bc20709220d51531
Publikováno v:
Experimental & Molecular Medicine. 54:1146-1155
Phospholipase D2 (PLD2), a signaling protein, plays a central role in cellular communication and various biological processes. Here, we show that PLD2 contributes to bone homeostasis by regulating bone resorption through osteoclastic cell migration a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e587932beb2de613d69965808ffe1e4a
https://doi.org/10.1038/s12276-022-00820-1
https://doi.org/10.1038/s12276-022-00820-1
Autor:
Byunghyuk Lee, Yuna Jo, Geona Kim, Laraib Amir Ali, Dong Hyun Sohn, Seung-Geun Lee, Kiseok Kim, Euisu Shin, Sung Ho Ryu, Changwan Hong
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
IL-17 produced by Th17 cells has been implicated in the pathogenesis of rheumatoid arthritis (RA). It is important to prevent the differentiation of Th17 cells in RA. Homodimeric soluble γc (sγc) impairs IL-2 signaling and enhances Th17 differentia
Externí odkaz:
https://doaj.org/article/5afdc3c4c5f14dc6bcef80d79a3b7400