Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Sung Soo Chung"'
Publikováno v:
Diabetes & Metabolism Journal, Vol 47, Iss 3, Pp 382-393 (2023)
Background Leptin is a 16-kDa fat-derived hormone with a primary role in controlling adipose tissue levels. Leptin increases fatty acid oxidation (FAO) acutely through adenosine monophosphate-activated protein kinase (AMPK) and on delay through the S
Externí odkaz:
https://doaj.org/article/b1ff0df4ecad425c8dc334ca21d5a650
Autor:
Min Joo Kim, Young Do Koo, Min Kim, Soo Lim, Young Joo Park, Sung Soo Chung, Hak C. Jang, Kyong Soo Park
Publikováno v:
Diabetes & Metabolism Journal, Vol 40, Iss 5, Pp 406-413 (2016)
BackgroundPanax ginseng has glucose-lowering effects, some of which are associated with the improvement in insulin resistance in skeletal muscle. Because mitochondria play a pivotal role in the insulin resistance of skeletal muscle, we investigated t
Externí odkaz:
https://doaj.org/article/71c63fc2c1164338b6d0774f57df6dab
Autor:
Hwa Young Ahn, Hwan Hee Kim, Ye An Kim, Min Kim, Jung Hun Ohn, Sung Soo Chung, Yoon-Kwang Lee, Do Joon Park, Kyong Soo Park, David D. Moore, Young Joo Park
Publikováno v:
Endocrinology and Metabolism, Vol 30, Iss 4, Pp 584-592 (2015)
BackgroundExpression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP). In this study, we aimed to find whether thyroid hormone regulates SHP expression by modulating th
Externí odkaz:
https://doaj.org/article/564287f1004a45b79b00ad5a1bd5f7d2
Re-highlighting the action of PPARγ in treating metabolic diseases [version 1; referees: 2 approved]
Publikováno v:
F1000Research, Vol 7 (2018)
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor family and plays an important role in adipocyte differentiation, glucose homeostasis, and insulin sensitivity. Thiazolidinediones (TZDs), synthetic ligands of
Externí odkaz:
https://doaj.org/article/9a0965d8528d40c58449588232645b93
Autor:
Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Min Kyeong Kim, Jung Hee Kim, Masaaki Komatsu, Keiji Tanaka, Hakmo Lee, Sung Soo Chung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hye Seung Jung
Publikováno v:
Endocrinology and Metabolism, Vol 30, Iss 1, Pp 65-70 (2015)
BackgroundDamaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells. Here, we investigated mitochondrial function and the e
Externí odkaz:
https://doaj.org/article/62f226d53fad44aa928949c525abd125
Publikováno v:
Genomics & Informatics, Vol 12, Iss 4, Pp 240-246 (2014)
Mutation in HNF1B, the hepatocyte nuclear factor-1β (HNF-1β) gene, results in maturity-onset diabetes of the young (MODY) 5, which is characterized by gradual impairment of insulin secretion. However, the functional role of HNF-1β in insulin secre
Externí odkaz:
https://doaj.org/article/17838f89745b4dac9d4683a373940255
Publikováno v:
Diabetes & Metabolism Journal, Vol 35, Iss 4, Pp 340-347 (2011)
BackgroundSulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PP
Externí odkaz:
https://doaj.org/article/57f65d2de31a49059448650e1add4849
Autor:
Min Kim, Ji Seon Lee, Joo En Oh, Jinyan Nan, Hakmo Lee, Hye Seung Jung, Sung Soo Chung, Kyong Soo Park
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124744 (2015)
Abnormally high levels of circulating free fatty acids can lead to pancreatic islet β-cell dysfunction and apoptosis, contributing to β-cell failure in Type 2 diabetes. The NAD+-dependent protein deacetylase Sirtuin-3 (SIRT3) has been implicated in
Externí odkaz:
https://doaj.org/article/a4a7586c027948f89f3c5ad880823ea6
Autor:
Hye Seung Jung, Min Joo Kim, Shin Hee Hong, Ye Jin Lee, Shiane Kang, Hakmo Lee, Sung Soo Chung, Joong Shin Park, Kyong Soo Park M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Early graft loss in islet transplantation means that a large amount of donor islets is required. Endothelial cells and endothelial colony-forming cells (ECFCs) have been reported to improve instant blood-mediated inflammatory reaction (IBMIR) in vitr
Externí odkaz:
https://doaj.org/article/71b493198797484080cf333ba6bd0ff0
Autor:
Jinyan Nan, Ji Seon Lee, Joon Ho Moon, Seung-Ah Lee, Young Joo Park, Dong-Sup Lee, Sung Soo Chung, Kyong Soo Park
Publikováno v:
Experimental & Molecular Medicine. 54:72-80
Increasing evidence has shown that small ubiquitin-like modifier (SUMO) modification plays an important role in metabolic regulation. We previously demonstrated that SUMO-specific protease 2 (SENP2) is involved in lipid metabolism in skeletal muscle