A Review of the Microbial Production of Bioactive Natural Products and Biologics

Autor: Janette V. Pham, Mariamawit A. Yilma, Adriana Feliz, Murtadha T. Majid, Nicholas Maffetone, Jorge R. Walker, Eunji Kim, Hyo Je Cho, Jared M. Reynolds, Myoung Chong Song, Sung Ryeol Park, Yeo Joon Yoon

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites, also known as natural products. Natural products have been a prolific source and an inspiration for numerous medical agents with widely divergent chemical str

Externí odkaz: https://doaj.org/article/57e48d1d38c04c02a1b8543384b89670

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C—H Functionalization

Autor: Pamela J. Schultz, Nisha Korakavi, David H. Sherman, Matthew D. DeMars, Samuel T. Slocum, Jennifer K. Priessnitz, Andrew N. Lowell, Krithika Anand, Sung Ryeol Park, Fengan Yu, Joseph A. Chemler, Aaron A. Koch

Publikováno v: Journal of the American Chemical Society. 139:7913-7920

Polyketide synthases (PKSs) represent a powerful catalytic platform capable of effecting multiple carbon-carbon bond forming reactions and oxidation state adjustments. We explored the functionality of two terminal PKS modules that produce the 16-memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24812c806df0b1c1598600f29c4b4c75
https://doi.org/10.1021/jacs.7b02875

A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ

Autor: Janet L. Smith, Hyo Je Cho, Ashootosh Tripathi, Brian Lee, Andrew P. Sikkema, Chuanwu Xi, David H. Sherman, Jianfeng Wu, Sung Ryeol Park

Publikováno v: Chembiochem : a European journal of chemical biology. 19(15)

Cahuitamycins are biofilm inhibitors assembled by a convergent nonribosomal peptide synthetase pathway. Previous genetic analysis indicated that a discrete enzyme, CahJ, serves as a gatekeeper for cahuitamycin structural diversification. Here, the Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd922a396c3357f219484fc03d46f607
https://pubmed.ncbi.nlm.nih.gov/29742306

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides

Autor: Alexander S. Mankin, Stephen Douthwaite, Nora Vázquez-Laslop, Sung Ryeol Park, Mashal M. Almutairi, Douglas A. Hansen, Simon Rose, David H. Sherman

Publikováno v: Almutairi, M M, Park, S R, Rose, S, Hansen, D A, Vázquez-Laslop, N, Douthwaite, S, Sherman, D H & Mankin, A S 2015, ' Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides ', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 42, pp. 12956-12961 . https://doi.org/10.1073/pnas.1512090112

Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, in part because of the low propensity of these drugs to trigger the expression of resistance genes. A natural ketolide pikromycin and a related com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85cf2376a84fe606ce13f7ea1360ff7
https://doi.org/10.1073/pnas.1512090112

Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects.

Autor: Sung Ryeol Park¹, Ah Reum Han², Yeon-Hee Ban¹, Young Ji Yoo¹, Eun Ji Kim¹, Yeo Joon Yoon¹ joonyoon@ewha.ac.kr

Publikováno v: Applied Microbiology & Biotechnology. Feb2010, Vol. 85 Issue 5, p1227-1239. 13p. 6 Diagrams, 1 Chart.