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Functional Consequences of Directed Mutations in Human Papillomavirus E6 Proteins: Abrogation of p53-Mediated Cell Cycle Arrest Correlates with p53 Binding and Degradation in Vitro

Autor: Lora Hedrick, Theodore D. Kessis, Sung M. Han, Kathleen R. Cho, Alex W. Chen, Robbert J. C. Slebos

Publikováno v: Virology. 208:111-120

Clinical and epidemiological studies have implicated the involvement of human papillomavirus (HPV) infection in cervical tumorigenesis. We have previously shown that expression of high-risk (HPV16) E6 can abrogate an important cell cycle checkpoint m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60450a920d10cdf3a1affff18833ba3
https://doi.org/10.1006/viro.1995.1134

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Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

Autor: Beverly Plunkett, William G. Nelson, Michael B. Kastan, Sung M. Han, Theodore D. Kessis, Robert J. Slebos, Lora Hedrick, Attila T. Lorincz, Kathleen R. Cho

Publikováno v: Proceedings of the National Academy of Sciences. 90:3988-3992

Infection with certain types of human papillomaviruses (HPV) is highly associated with carcinomas of the human uterine cervix. However, HPV infection alone does not appear to be sufficient for the process of malignant transformation, suggesting the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3529410a6a5adf9f971477aa6b21cd8
https://doi.org/10.1073/pnas.90.9.3988

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