Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Sung Hee Um"'
Publikováno v:
Cells, Vol 12, Iss 2, p 205 (2023)
The pyrimidine derivative YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido(2,3-d)-pyrimidin-2(1H)-one) exerts anti-inflammatory and anti-asthmatic effects. Considering that accumulation of lipids in adipose tissue is accompanied by inflammation, we invest
Externí odkaz:
https://doaj.org/article/4a7ee552ef7444929f16e303c1484d5b
Autor:
Hee Jung Kim, Da Eun Lee, Eon Chung Park, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Sung Hee Um, Ki Hyun Kim
Publikováno v:
Molecules, Vol 27, Iss 20, p 6954 (2022)
Salix pseudolasiogyne (Salicaceae), the “weeping willow,” has been used in traditional Korean medicine to treat pain and fever due to its high concentrations of salicylic acid and salicin. The present study investigated bioactive compounds from S
Externí odkaz:
https://doaj.org/article/76925850a6c447b5b4e8d49711394ddc
Autor:
Hee Jung Kim, Yoon Seo Jang, Ji Won Ha, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Kyunga Kim, Ki Hyun Kim, Sung Hee Um
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 12006 (2022)
Salix pseudolasiogyne (Salicaceae) is a willow tree and has been used as a medicinal herb in Korea to treat pain and fever. As a part of an ongoing study to identify bioactive natural products, potential anti-adipogenic compounds were investigated us
Externí odkaz:
https://doaj.org/article/c2bc1809241344b4b40221fb07830855
Publikováno v:
Molecular Metabolism, Vol 21, Iss , Pp 82-89 (2019)
Objectives: During fasting, hepatic gluconeogenesis is induced to maintain energy homeostasis. Moreover, abnormal dysregulation of hepatic glucose production is commonly observed in type 2 diabetes. However, the signaling components controlling hepat
Externí odkaz:
https://doaj.org/article/2c34c30863ea43a3ae59e2538daa1179
Autor:
Seul Lee, Hyun-Soo Roh, Seong-Soo Song, Jimin Shin, Jangchoon Lee, Dong Ha Bhang, Byung Gak Kim, Sung Hee Um, Han-Sin Jeong, Kwan-Hyuck Baek
Publikováno v:
Translational Oncology, Vol 13, Iss 4, Pp - (2020)
Two isoforms of the 70-kDa ribosomal protein S6 kinase, S6K1 and S6K2, have been identified and are considered key downstream effectors of the mTOR signaling pathway, which is involved in tumor growth and progression. However, their biological roles
Externí odkaz:
https://doaj.org/article/035742c48be8434f87794e363fffc3b0
Autor:
Mun-Gyu Song, Hye-Jin Lee, Bo-Yeong Jin, Ruth Gutierrez-Aguilar, Kyung-Ho Shin, Sang-Hyun Choi, Sung Hee Um, Dong-Hoon Kim
Publikováno v:
Molecular Metabolism, Vol 5, Iss 11, Pp 1113-1120 (2016)
Objective: Adipose tissue (AT) expansion requires AT remodeling, which depends on AT angiogenesis. Modulation of AT angiogenesis could have therapeutic promise for the treatment of obesity. However, it is unclear how the capacity of angiogenesis in e
Externí odkaz:
https://doaj.org/article/bf95ac3346e143b9bba48b14de3ba838
Publikováno v:
Biomedicines, Vol 8, Iss 11, p 485 (2020)
Diabetes is a concerning health malady worldwide. Islet or pancreas transplantation is the only long-term treatment available; however, the scarcity of transplantable tissues hampers this approach. Therefore, new cell sources and differentiation appr
Externí odkaz:
https://doaj.org/article/7a8741a27b9348079d62ffab92c151bd
Publikováno v:
Cells, Vol 8, Iss 11, p 1460 (2019)
Carbamazepine is a drug that is widely used in the treatment of epilepsy and bipolar disorder. The prevalence of obesity in patients treated with carbamazepine has been frequently reported. However, whether carbamazepine affects adipogenesis, one of
Externí odkaz:
https://doaj.org/article/0c58fd032c4f439193b34b11dd9f0441
Publikováno v:
Cells, Vol 8, Iss 10, p 1137 (2019)
The vacuolar H+-adenosine triphosphatase (ATPase) subunit V0C (ATP6V0C), a proton-conducting, pore-forming subunit of vacuolar ATPase, maintains pH homeostasis and induces organelle acidification. The intracellular and extracellular pH of cancer cell
Externí odkaz:
https://doaj.org/article/6a55b23d478b4a948784136279f67306
Autor:
Tamara R Castañeda, William Abplanalp, Sung Hee Um, Paul T Pfluger, Brigitte Schrott, Kimberly Brown, Erin Grant, Larissa Carnevalli, Stephen C Benoit, Donald A Morgan, Dean Gilham, David Y Hui, Kamal Rahmouni, George Thomas, Sara C Kozma, Deborah J Clegg, Matthias H Tschöp
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32631 (2012)
Targeted deletion of S6 kinase (S6K) 1 in mice leads to higher energy expenditure and improved glucose metabolism. However, the molecular mechanisms controlling these effects remain to be fully elucidated. Here, we analyze the potential role of dieta
Externí odkaz:
https://doaj.org/article/7da010e228ee4cde9cfbd8ad394306a7