Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Sung Bae Lee"'
Autor:
Byung Su Ko, Myeong Hoon Han, Min Jee Kwon, Dong Gon Cha, Yuri Ji, Eun Seo Park, Min Jae Jeon, Somi Kim, Kyeongho Lee, Yoon Ha Choi, Jusung Lee, Monica Torras-Llort, Ki-Jun Yoon, Hyosang Lee, Jong Kyoung Kim, Sung Bae Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 422-440 (2024)
Abstract Accumulating evidence hints heterochromatin anchoring to the inner nuclear membrane as an upstream regulatory process of gene expression. Given that the formation of neural progenitor cell lineages and the subsequent maintenance of postmitot
Externí odkaz:
https://doaj.org/article/1ec26a52f76942f19aa7aa5402f7c822
Publikováno v:
Cells, Vol 13, Iss 11, p 955 (2024)
Ubiquitin-specific protease 14 (USP14), one of the three major proteasome-associated deubiquitinating enzymes (DUBs), is known to be activated by the AKT-mediated phosphorylation at Ser432. Thereby, AKT can regulate global protein degradation by cont
Externí odkaz:
https://doaj.org/article/4d13bbc13459476995d89c34a7182773
Autor:
Seong Keun Sonn, Eun Ju Song, Seungwoon Seo, Young Yeon Kim, Jee-Hyun Um, Franklin Joonyeop Yeo, Da Seul Lee, Sejin Jeon, Mi-Ni Lee, Jing Jin, Hyae Yon Kweon, Tae Kyeong Kim, Sinai Kim, Shin Hye Moon, Sue Goo Rhee, Jongkyeong Chung, Jaemoon Yang, Jin Han, Eui-Young Choi, Sung Bae Lee, Jeanho Yun, Goo Taeg Oh
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102275- (2022)
Mitochondrial quality control (MQC) consists of multiple processes: the prevention of mitochondrial oxidative damage, the elimination of damaged mitochondria via mitophagy and mitochondrial fusion and fission. Several studies proved that MQC impairme
Externí odkaz:
https://doaj.org/article/b06c28f81d344d92b4d31826df3188a6
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1351-1359 (2020)
Aging: Slowing down of nucleocytoplasmic trafficking Proteins that move genetic information out of the nucleus and into the rest of the cell may be important in aging, and serve as markers of early-stage cancer. DNA is stored in the cell’s nucleus,
Externí odkaz:
https://doaj.org/article/b38fea8e142543a68bac03bc0f91fb95
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The lack of early diagnostic biomarkers for schizophrenia greatly limits treatment options that deliver therapeutic agents to affected cells at a timely manner. While previous schizophrenia biomarker research has identified various biological signals
Externí odkaz:
https://doaj.org/article/8f0e77b326464418bbc9c9772a40590e
Autor:
Young Yeon Kim, Jeong-Hyun Yoon, Jee-Hyun Um, Dae Jin Jeong, Dong Jin Shin, Young Bin Hong, Jong Kuk Kim, Dong Hyun Kim, Changsoo Kim, Chang Geon Chung, Sung Bae Lee, Hyongjong Koh, Jeanho Yun
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257439 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0239126.].
Externí odkaz:
https://doaj.org/article/24e85f5550e048afa8920d9a257d5b52
Autor:
Jeong Hyang Park, Chang Geon Chung, Sung Soon Park, Davin Lee, Kyung Min Kim, Yeonjin Jeong, Eun Seon Kim, Jae Ho Cho, Yu-Mi Jeon, C-K James Shen, Hyung-Jun Kim, Daehee Hwang, Sung Bae Lee
Publikováno v:
eLife, Vol 9 (2020)
Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to
Externí odkaz:
https://doaj.org/article/46d3424812544032a682295a9de759aa
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Due to their enormous surface area compared to other cell types, neurons face unique challenges in properly handling supply and retrieval of the plasma membrane (PM)—a process termed PM turnover—in their distal areas. Because of the length and ex
Externí odkaz:
https://doaj.org/article/3843018eef52405f8d42f1ac42cce775
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Polyglutamine (polyQ) spinocerebellar ataxias (SCAs) are the most prevalent subset of SCAs and share the aberrant expansion of Q-encoding CAG repeats within the coding sequences of disease-responsible genes as their common genetic cause. These polyQ
Externí odkaz:
https://doaj.org/article/011a88b9cef648e09c4c19b448244909
Autor:
Young Yeon Kim, Jeong-Hyun Yoon, Jee-Hyun Um, Dae Jin Jeong, Dong Jin Shin, Young Bin Hong, Jong Kuk Kim, Dong Hyun Kim, Changsoo Kim, Chang Geon Chung, Sung Bae Lee, Hyongjong Koh, Jeanho Yun
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239126 (2020)
Paclitaxel is a representative anticancer drug that induces chemotherapy-induced peripheral neuropathy (CIPN), a common side effect that limits many anticancer chemotherapies. Although PINK1, a key mediator of mitochondrial quality control, has been
Externí odkaz:
https://doaj.org/article/f765cfb95b9c44a49c4cdb9c2bb1a631