Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sung Ah Hong"'
Autor:
Jae-Hyeok Kang, Nizam Uddin, Seungmo Kim, Yi Zhao, Ki-Chun Yoo, Min-Jung Kim, Sung-Ah Hong, Sangsu Bae, Jeong-Yeon Lee, Incheol Shin, Young Woo Jin, Heather M. O’Hagan, Joo Mi Yi, Su-Jae Lee
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-18 (2024)
Abstract Triple-negative breast cancer (TNBC), the most aggressive subtype, presents a critical challenge due to the absence of approved targeted therapies. Hence, there is an urgent need to identify effective therapeutic targets for this condition.
Externí odkaz:
https://doaj.org/article/6c5a1e8d71c14b51abf556d24cb132c7
Autor:
Sung-Ah Hong, Song-Ee Kim, A-Young Lee, Gue-Ho Hwang, Jong Hoon Kim, Hiroaki Iwata, Soo-Chan Kim, Sangsu Bae, Sang Eun Lee
Publikováno v:
Molecular Therapy. 30:2664-2679
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin fragility disorder caused by loss-of-function mutations in the COL7A1 gene, which encodes type VII collagen (C7), a protein that functions in skin adherence. From 36 Korean RDEB patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252d2e28e1076b66b7484d8dd009a1b2
https://doi.org/10.1016/j.ymthe.2022.06.005
https://doi.org/10.1016/j.ymthe.2022.06.005
Autor:
Seok Hoon Lee, Jin-Soo Kim, Se eun Park, Gue Ho Hwang, Jae Sung Woo, Sung Ah Hong, Sangsu Bae, You Kyeong Jeong
Publikováno v:
Nature Biotechnology. 39:1426-1433
Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of interest. However, ABEs also induce cytosine deamination at the target site. To reduce the cytosine editing activity, we engineered a commonly used adenosine deamina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3892fc8bf9562da4bce41dca7241e7b3
https://doi.org/10.1038/s41587-021-00943-2
https://doi.org/10.1038/s41587-021-00943-2
Autor:
Sangsu Bae, Omer Habib, Sung Ah Hong, Gue Ho Hwang, You Kyeong Jeong, Jin-Soo Kim, Kayeong Lim
Publikováno v:
Nucleic Acids Research
Prime editing technology is capable of generating targeted insertions, deletions, and base conversions. However, the process of designing prime editing guide RNAs (pegRNAs), which contain a primer binding site and a reverse-transcription template at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586193db94ed15d4bf58ef3b45b4f0a7
http://europepmc.org/articles/PMC8265102
http://europepmc.org/articles/PMC8265102
Autor:
Duck-Hyun Kim, Jae-Seong Lee, Jun Chul Park, Eunjin Byeon, Hajime Watanabe, Yoseop Lee, Hye-Min Kang, Sangsu Bae, Min-Sub Kim, Yasuhiko Kato, Young-Hwan Lee, Alaa El-Din H. Sayed, Haksoo Jeong, Jin-Sol Lee, Sung-Ah Hong
Publikováno v:
Aquatic toxicology (Amsterdam, Netherlands). 242
The water flea Daphnia magna is a small freshwater planktonic animal in the Cladocera. In this study, we assembled the genome of the D. magna NIES strain, which is widely used for gene targeting but has no reported genome. We used the long-read seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6050c7b2c1b03bdd04bb8241041b1bab
https://pubmed.ncbi.nlm.nih.gov/34856461
https://pubmed.ncbi.nlm.nih.gov/34856461
Therapeutic base and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa
Autor:
Song-Ee Kim, Ayoung Lee, Jong Hoon Kim, Sang Eun Lee, Sangsu Bae, Gue-Ho Hwang, Sung-Ah Hong, Soo Chan Kim, Hiroaki Iwata
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin fragility disorder caused by loss-of-function mutations in the COL7A1 gene, which encodes type VII collagen (C7), a protein that functions in skin adherence. From 36 Korean RDEB patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::597781c1bd38e1e193b41cf85b20916d
https://doi.org/10.1101/2021.07.12.452037
https://doi.org/10.1101/2021.07.12.452037
Autor:
Sangsu Bae, Eul Sik Jung, Sung Rae Cho, Jihyeon Yu, Gue-Ho Hwang, Sung-Ah Hong, Soeon Park, Soohyun Wi, Jung Hwa Seo, Ahreum Baek, Ji Hea Yu
Publikováno v:
Mol Ther
Adrenoleukodystrophy (ALD) is caused by various pathogenic mutations in the X-linked ABCD1 gene, which lead to metabolically abnormal accumulations of very long-chain fatty acids in many organs. However, curative treatment of ALD has not yet been ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a82bb89ea5f09a59144429498996856
https://europepmc.org/articles/PMC8753287/
https://europepmc.org/articles/PMC8753287/
Autor:
Sung-Ah Hong, Keun Bon Ku, Seongjun Kim, Bum-Tae Kim, Sangsu Bae, Hyung Jin Cha, Chonsaeng Kim, Jihyeon Yu, Jun Hee Han, You Kyeong Jeong, Hye Jin Shin, Jae Sung Woo
Publikováno v:
Advanced Biology
The production of biomolecules that require human‐specific lipid environments is extremely useful for basic research and medical applications. In article number 2000154, Seong‐Jun Kim, Jae‐Sung Woo, Sangsu Bae, and co‐workers integrate multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412ff4ad0847df265c9382cd35613b4f
http://europepmc.org/articles/PMC8250180
http://europepmc.org/articles/PMC8250180
Autor:
Sangsu Bae, You Kyeong Jeong, Jae Sung Woo, Jin-Soo Kim, Se-eun Park, Sung-Ah Hong, SeokHoon Lee, Gue-Ho Hwang
Adenine base editors (ABEs) promise specific A-to-G conversions at genomic sites of interest. However, ABEs also induce cytosine deamination at the target DNA site and exhibit transcriptome-wide off-target RNA editing. To alleviate the ABE-mediated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c8947b331f71b2c2fe782ab7fe4ca4
https://doi.org/10.21203/rs.3.rs-84912/v1
https://doi.org/10.21203/rs.3.rs-84912/v1
Autor:
Yohan Kim, Jihyeon Yu, Sung-Ah Hong, Jeongyun Eom, Kiseok Jang, Seu-Na Lee, Jae-Sung Woo, Jaemin Jeong, Sangsu Bae, Dongho Choi
SummaryDNA base editors and prime editing technology capable of therapeutic base conversion enable ex vivo gene editing therapy for various genetic diseases. For such therapy, it is critical that the target cells survive well both outside the body an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c123e61a3924cafd01cda6985c1292c
https://doi.org/10.1101/2020.09.14.297275
https://doi.org/10.1101/2020.09.14.297275