Výsledky vyhledávání - "Suneeta Tumati"

Tachykinin NK1 receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation

Autor: Todd W. Vanderah, Tally M. Largent-Milnes, Eva V. Varga, Takashi Yamamoto, Victor J. Hruby, Attila Keresztes, Suneeta Tumati, William R. Roeske

Publikováno v: European Journal of Pharmacology. 684:64-70

Prolonged morphine treatment increases pain sensitivity in many patients. Enhanced spinal Substance P release is one of the adaptive changes associated with sustained opioid exposure. In addition to pain transmitting second order neurons, spinal micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f77ad6ed9d784eabd4a4cd2b1fb1287
https://doi.org/10.1016/j.ejphar.2012.03.025

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Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner

Autor: Todd W. Vanderah, Eva V. Varga, William R. Roeske, Suneeta Tumati

Publikováno v: European Journal of Pharmacology. 648:95-101

Tissue damage leads to pain sensitization due to peripheral and central release of excitatory mediators such as prostaglandin E 2 (PGE 2 ). PGE 2 sensitizes spinal pain neurotransmitter such as calcitonin gene-related peptide (CGRP) release via activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c2c09a1e21ee26998a4291f8dfab8a
https://doi.org/10.1016/j.ejphar.2010.08.042

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Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA

Autor: Tally M. Largent-Milnes, Eva V. Varga, Todd W. Vanderah, R Wang, William R. Roeske, Suneeta Tumati

Publikováno v: British Journal of Pharmacology. 161:51-64

BACKGROUND AND PURPOSE Long-term morphine treatment enhances pain neurotransmitter [such as calcitonin gene-related peptide (CGRP)] levels in the spinal cord. It has been suggested previously that increased spinal CGRP may contribute to sustained mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d3575e57cd54b73dc280bd4e8cf6ad0
https://doi.org/10.1111/j.1476-5381.2010.00869.x

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Sustained Morphine Treatment Augments Capsaicin-Evoked Calcitonin Gene-Related Peptide Release from Primary Sensory Neurons in a Protein Kinase A- and Raf-1-Dependent Manner

Autor: Henry I. Yamamura, Eva V. Varga, Todd W. Vanderah, Suneeta Tumati, William R. Roeske

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 330:810-817

Studies have shown that long-term (5α,6α)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia). The cellular adaptations contributing to sustained morphine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe3cafa8e44f0613594cd75b7afa425
https://doi.org/10.1124/jpet.109.151704

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Plasmon–waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells

Autor: J. Fitch, Gordon Tollin, Edita Navratilova, Zdzislaw Salamon, Suneeta Tumati, Minying Cai

Publikováno v: Analytical Biochemistry. 387:95-101

A procedure has been developed for directly depositing membrane fragments derived from bacterial cells (chromatophores from Rhodopseudomonas sphaeroides) and mammalian cells (μ-opioid receptor- and MC4 receptor-transfected human embryonic kidney (HE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cf620d7563dcf085d2088e01c16c8e
https://doi.org/10.1016/j.ab.2009.01.019

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Functional Selectivity in Cannabinoid Signaling

Autor: Zdzislaw Salamon, Isabel D. Alves, Gordon Tollin, Suneeta Tumati, Teodora Georgieva, William R. Roeske, Henry I. Yamamura, Eva V. Varga

Publikováno v: Current Molecular Pharmacology. 1:273-284

Cannabinoid (CB) agonists exhibit numerous potentially useful pharmacological properties, but unwanted side effects limit their use in clinical practice. Thus, novel strategies are needed to identify potential CB pharmaceuticals with fewer side effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857214b5fa2a3cb5c6d850a3460b8e17
https://doi.org/10.2174/1874467210801030273

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A Structure–Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are δ/μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

Autor: Josephine Lai, Todd W. Vanderah, Peg Davis, Sharif Moye, Tally M. Largent-Milnes, Padma Nair, Henry I. Yamamura, Takashi Yamamoto, Edita Navratilova, Shou Wu Ma, Josef Vagner, Victor J. Hruby, Suneeta Tumati, Frank Porreca

Publikováno v: Journal of Medicinal Chemistry. 51:1369-1376

A series of bifunctional peptides with opioid agonist and substance P antagonist bioactivities were designed with the concept of overlapping pharmacophores. In this concept, the bifunctional peptides were expected to interact with each receptor separ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6d5231fe24dcd9400e8983c030f0ec
https://doi.org/10.1021/jm070332f

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Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation

Autor: Suneeta, Tumati, Tally M, Largent-Milnes, Attila I, Keresztes, Takashi, Yamamoto, Todd W, Vanderah, William R, Roeske, Victor J, Hruby, Eva V, Varga

Publikováno v: European journal of pharmacology. 684(1-3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c506dcbc163c3b71f90b805aefe2c883
https://pubmed.ncbi.nlm.nih.gov/22724132

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Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist

Autor: Tally M. Largent-Milnes, Jiyang Ren, Todd W. Vanderah, William R. Roeske, Eva V. Varga, Attila Keresztes, Suneeta Tumati

Publikováno v: Journal of neuroimmunology. 244(1-2)

Spinal glial activation has been implicated in sustained morphine-mediated paradoxical pain sensitization. Since activation of glial CB2 cannabinoid receptors attenuates spinal glial activation in neuropathies, we hypothesized that CB2 agonists may a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f488addbc76b3edd035068245ddae6a
https://pubmed.ncbi.nlm.nih.gov/22285397

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Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist

Autor: Frank Porreca, Steven Ballet, Jozef Vanden Broeck, Koen Buysse, Attila Keresztes, Nga N. Chung, Josephine Lai, Eva V. Varga, Peter W. Schiller, Suneeta Tumati, Carole Lemieux, Dirk Tourwé, Debby Feytens, Joost Van Duppen

Publikováno v: Journal of medicinal chemistry. 54(7)

A screening of conformationally constrained aromatic amino acids as base cores for the preparation of new NK1 receptor antagonists resulted in the discovery of three new NK1 receptor antagonists, 19 [Ac-Aba-Gly-NH-3',5'-(CF(3))(2)-Bn], 20 [Ac-Aba-Gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a329ad8e013b535383acac93144da88
https://pubmed.ncbi.nlm.nih.gov/21413804

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