Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Suneel S Apte"'
Autor:
Jill T Kuwabara, Akitoshi Hara, Sumit Bhutada, Greg S Gojanovich, Jasmine Chen, Kanani Hokutan, Vikram Shettigar, Anson Y Lee, Lydia P DeAngelo, Jack R Heckl, Julia R Jahansooz, Dillon K Tacdol, Mark T Ziolo, Suneel S Apte, Michelle D Tallquist
Publikováno v:
eLife, Vol 11 (2022)
Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many cardiac pathologies and is generally deleterious, the role of fibroblasts in maintaining the
Externí odkaz:
https://doaj.org/article/59bd1881150d4f2a8b06cd161b15c44e
Autor:
Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter Reinhardt, Cecilia Lo, Clair Baldock, Suneel S Apte
Publikováno v:
eLife, Vol 11 (2022)
The embryonic extracellular matrix (ECM) undergoes transition to mature ECM as development progresses, yet few mechanisms ensuring ECM proteostasis during this period are known. Fibrillin microfibrils are macromolecular ECM complexes serving structur
Externí odkaz:
https://doaj.org/article/5a97c8b12bf54934ac67208635fbd524
Autor:
Sumeda Nandadasa, Jason M Szafron, Vai Pathak, Sae-Il Murtada, Caroline M Kraft, Anna O'Donnell, Christian Norvik, Clare Hughes, Bruce Caterson, Miriam S Domowicz, Nancy B Schwartz, Karin Tran-Lundmark, Martina Veigl, David Sedwick, Elliot H Philipson, Jay D Humphrey, Suneel S Apte
Publikováno v:
eLife, Vol 9 (2020)
The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan
Externí odkaz:
https://doaj.org/article/9109ace5da5c44e6ba1fbd9d2ece7d9d
Autor:
Laura Kuczynski-Noyau, Sixtine Karmann, Paolo Alberton, Ines Martinez-Corral, Sreekala Nampoothiri, Florent Sauvé, Tori Lhomme, Carmelo Quarta, Suneel S. Apte, Sébastien Bouret, Attila Aszodi, Sowmyalakshmi Rasika, Philippe Ciofi, Julie Dam, Vincent Prévot, Virginie Mattot
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The hypothalamic arcuate nucleus (ARH) contains neurons vital for maintaining energy homeostasis that sense and respond to changes in blood-borne metabolic hormones. Despite its juxtaposition to the median eminence (ME), a circumventricular
Externí odkaz:
https://doaj.org/article/e94870fe89f04d25bdc4bbe95aec86d1
Autor:
Hannah L Bader, Alison L Ruhe, Lauren W Wang, Aaron K Wong, Kari F Walsh, Rebecca A Packer, Jonathan Mitelman, Kathryn R Robertson, Dennis P O'Brien, Karl W Broman, G Diane Shelton, Suneel S Apte, Mark W Neff
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Musladin-Lueke Syndrome (MLS) is a hereditary disorder affecting Beagle dogs that manifests with extensive fibrosis of the skin and joints. In this respect, it resembles human stiff skin syndrome and the Tight skin mouse, each of which is caused by g
Externí odkaz:
https://doaj.org/article/418807d82d704dbd8a76c3dd9b02741c
Publikováno v:
PLoS Genetics, Vol 4, Iss 2, p e1000003 (2008)
ADAMTS20 (Adisintegrin-like and metalloprotease domain with thrombospondin type-1 motifs) is a member of a family of secreted metalloproteases that can process a variety of extracellular matrix (ECM) components and secreted molecules. Adamts20 mutati
Externí odkaz:
https://doaj.org/article/7c487188cd8945b297a9844b18f4339c
Autor:
Sumit Bhutada, Karin Tran-Lundmark, Benjamin Kramer, Peter Conner, Ashley M. Lowry, Eugene Blackstone, Bjorn Frenckner, Carmen Mesas-Burgos, Suneel S. Apte
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Congenital diaphragmatic hernia (CDH) is a severe birth defect frequently associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure. Since amniotic fluid comprises proteins of both fetal and maternal origin, its analysi
Externí odkaz:
https://doaj.org/article/586eac0df2f84f90852889233d23556b
Autor:
Oscar van derHave, Timothy J. Mead, Christian Westöö, Niccolò Peruzzi, Ayse C. Mutgan, Christian Norvik, Martin Bech, André Struglics, Konrad Hoetzenecker, Hans Brunnström, Gunilla Westergren‐Thorsson, Grazyna Kwapiszewska, Suneel S. Apte, Karin Tran‐Lundmark
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Expansion of extracellular matrix occurs in all stages of pulmonary angiopathy associated with pulmonary arterial hypertension (PAH). In systemic arteries, dysregulation and accumulation of the large chondroitin‐sulfate proteoglycan aggrec
Externí odkaz:
https://doaj.org/article/9ec517eecbfa42948ac1c94d671fac5f
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C651-C665
Proteoglycans are composite molecules comprising a protein backbone, i.e., the core protein, with covalently attached glycosaminoglycan chains of distinct chemical types. Most proteoglycans are secreted or attached to the cell membrane. Their special
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69c89ea353b1a8b849ce333a5ed7699
https://doi.org/10.1152/ajpcell.00215.2022
https://doi.org/10.1152/ajpcell.00215.2022
Autor:
Jay S. Wunder, Benjamin A. Alman, Karen McGovern, Suneel S. Apte, Lauren W. Wang, Jennifer Proctor, John Keilty, Qingxia Wei, Raymond Poon, Heather Whetstone, Chang Ye Yale Wang, S. Amanda Ali, Puviindran Nadesan, Veronica T. Campbell
PDF - 71K, A list of the solid tumor xenografts tested for regulation of human or murine Gli1 following IPI-926 treatment, as measured by q-RT-PCR on whole tumor RNA extracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638ed50f91999fe61a2302b662e42782
https://doi.org/10.1158/1535-7163.22500406.v1
https://doi.org/10.1158/1535-7163.22500406.v1
