Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Suneel S, Apte"'
Autor:
Laura Kuczynski-Noyau, Sixtine Karmann, Paolo Alberton, Ines Martinez-Corral, Sreekala Nampoothiri, Florent Sauvé, Tori Lhomme, Carmelo Quarta, Suneel S. Apte, Sébastien Bouret, Attila Aszodi, Sowmyalakshmi Rasika, Philippe Ciofi, Julie Dam, Vincent Prévot, Virginie Mattot
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The hypothalamic arcuate nucleus (ARH) contains neurons vital for maintaining energy homeostasis that sense and respond to changes in blood-borne metabolic hormones. Despite its juxtaposition to the median eminence (ME), a circumventricular
Externí odkaz:
https://doaj.org/article/e94870fe89f04d25bdc4bbe95aec86d1
Autor:
Sumit Bhutada, Karin Tran-Lundmark, Benjamin Kramer, Peter Conner, Ashley M. Lowry, Eugene Blackstone, Bjorn Frenckner, Carmen Mesas-Burgos, Suneel S. Apte
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Congenital diaphragmatic hernia (CDH) is a severe birth defect frequently associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure. Since amniotic fluid comprises proteins of both fetal and maternal origin, its analysi
Externí odkaz:
https://doaj.org/article/586eac0df2f84f90852889233d23556b
Autor:
Karoline B. Rypdal, A. Olav Melleby, Emma L. Robinson, Jia Li, Sheryl Palmero, Deborah E. Seifert, Daniel Martin, Catelyn Clark, Begoña López, Kristine Andreassen, Christen P. Dahl, Ivar Sjaastad, Theis Tønnessen, Mathis K. Stokke, William E. Louch, Arantxa González, Stephane Heymans, Geir Christensen, Suneel S. Apte, Ida G. Lunde
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The role of ADAMTSL3 in heart pathology and cardiac disease is investigated with Adamtsl3-deficient mice using CRISPR-Cas9 gene editing.
Externí odkaz:
https://doaj.org/article/8dc2cdb39a0043879864fac9c8cf91a5
Autor:
Oscar van derHave, Timothy J. Mead, Christian Westöö, Niccolò Peruzzi, Ayse C. Mutgan, Christian Norvik, Martin Bech, André Struglics, Konrad Hoetzenecker, Hans Brunnström, Gunilla Westergren‐Thorsson, Grazyna Kwapiszewska, Suneel S. Apte, Karin Tran‐Lundmark
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Expansion of extracellular matrix occurs in all stages of pulmonary angiopathy associated with pulmonary arterial hypertension (PAH). In systemic arteries, dysregulation and accumulation of the large chondroitin‐sulfate proteoglycan aggrec
Externí odkaz:
https://doaj.org/article/9ec517eecbfa42948ac1c94d671fac5f
Autor:
Karoline B. Rypdal, Pugazendhi M. Erusappan, A. Olav Melleby, Deborah E. Seifert, Sheryl Palmero, Mari E. Strand, Theis Tønnessen, Christen P. Dahl, Vibeke Almaas, Dirk Hubmacher, Suneel S. Apte, Geir Christensen, Ida G. Lunde
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Fibrosis accompanies most heart diseases and is associated with adverse patient outcomes. Transforming growth factor (TGF)β drives extracellular matrix remodelling and fibrosis in the failing heart. Some members of the ADAMTSL (a disintegri
Externí odkaz:
https://doaj.org/article/ce2aba904d844c0083d6fbfea2ad66f8
Autor:
Jill T Kuwabara, Akitoshi Hara, Sumit Bhutada, Greg S Gojanovich, Jasmine Chen, Kanani Hokutan, Vikram Shettigar, Anson Y Lee, Lydia P DeAngelo, Jack R Heckl, Julia R Jahansooz, Dillon K Tacdol, Mark T Ziolo, Suneel S Apte, Michelle D Tallquist
Publikováno v:
eLife, Vol 11 (2022)
Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many cardiac pathologies and is generally deleterious, the role of fibroblasts in maintaining the
Externí odkaz:
https://doaj.org/article/59bd1881150d4f2a8b06cd161b15c44e
Autor:
Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter Reinhardt, Cecilia Lo, Clair Baldock, Suneel S Apte
Publikováno v:
eLife, Vol 11 (2022)
The embryonic extracellular matrix (ECM) undergoes transition to mature ECM as development progresses, yet few mechanisms ensuring ECM proteostasis during this period are known. Fibrillin microfibrils are macromolecular ECM complexes serving structur
Externí odkaz:
https://doaj.org/article/5a97c8b12bf54934ac67208635fbd524
Autor:
Dalya Ataca, Patrick Aouad, Céline Constantin, Csaba Laszlo, Manfred Beleut, Marie Shamseddin, Renuga Devi Rajaram, Rachel Jeitziner, Timothy J. Mead, Marian Caikovski, Philipp Bucher, Giovanna Ambrosini, Suneel S. Apte, Cathrin Brisken
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
How hormonal signaling in the mammary epithelium controls the surrounding extracellular matrix is unclear. Here, the authors show that a secreted protease, Adamts18, induced by upstream estrogen-progesterone activated Wnt4 in myoepithelial cells, rem
Externí odkaz:
https://doaj.org/article/d8bdc001db1a46d1897587347f7e2b51
Autor:
Sumeda Nandadasa, Cyril Burin des Roziers, Christopher Koch, Karin Tran-Lundmark, María T. Dours-Zimmermann, Dieter R. Zimmermann, Sophie Valleix, Suneel S. Apte
Publikováno v:
Matrix Biology Plus, Vol 10, Iss , Pp 100064- (2021)
Two inherent challenges in the mechanistic interpretation of protease-deficient phenotypes are defining the specific substrate cleavages whose reduction generates the phenotypes and determining whether the phenotypes result from loss of substrate fun
Externí odkaz:
https://doaj.org/article/05b26508a52446369487b95a2ee971df
Autor:
Sumeda Nandadasa, Caroline M. Kraft, Lauren W. Wang, Anna O’Donnell, Rushabh Patel, Heon Yung Gee, Kay Grobe, Timothy C. Cox, Friedhelm Hildebrandt, Suneel S. Apte
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique p
Externí odkaz:
https://doaj.org/article/ab5baac1ec5848ec9b9f690a16ccfcb8