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of 10
pro vyhledávání: '"Sundy N Y, Yang"'
Autor:
Sundy N. Y. Yang, Belinda Maher, Chunxiao Wang, Kylie M. Wagstaff, Johanna E. Fraser, David A. Jans
Publikováno v:
Cells, Vol 11, Iss 4, p 730 (2022)
Dengue virus (DENV) threatens almost 70% of the world’s population, with no effective therapeutic currently available and controversy surrounding the one approved vaccine. A key factor in dengue viral replication is the interaction between DENV non
Externí odkaz:
https://doaj.org/article/05b6d53bb1954601a1158139b2d94056
Autor:
Sundy N. Y. Yang, Sarah C. Atkinson, Michelle D. Audsley, Steven M. Heaton, David A. Jans, Natalie A. Borg
Publikováno v:
Cells, Vol 9, Iss 1, p 170 (2020)
Viral disease is one of the greatest burdens for human health worldwide, with an urgent need for efficacious antiviral strategies. While antiviral drugs are available, in many cases, they are prone to the development of drug resistance. A way to over
Externí odkaz:
https://doaj.org/article/4f0b210aaf3d40578aff1ed5a75063b4
Autor:
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg
Publikováno v:
Cells, Vol 8, Iss 10, p 1181 (2019)
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such
Externí odkaz:
https://doaj.org/article/3ad28a06abdf4916a62a2e524aadf905
Autor:
Sundy N. Y. Yang, Sarah C. Atkinson, Johanna E. Fraser, Chunxiao Wang, Belinda Maher, Noelia Roman, Jade K. Forwood, Kylie M. Wagstaff, Natalie A. Borg, David A. Jans
Publikováno v:
Cells, Vol 8, Iss 3, p 281 (2019)
Dengue virus (DENV) threatens almost 70% of the world’s population, with no effective vaccine or therapeutic currently available. A key contributor to infection is nuclear localisation in the infected cell of DENV nonstructural protein 5 (NS5) thro
Externí odkaz:
https://doaj.org/article/9700d13e0cf84c00a19a439db1d26680
Autor:
Micah L Burch, Peter J. Little, Sundy N Y Yang, Lisa R. Tannock, Stephen P. Evanko, Narin Osman
Publikováno v:
Journal of Diabetes. 2:233-242
Atherosclerosis is accelerated in the setting of diabetes, but the factors driving this phenomenon remain elusive. Hyperglycemia leads to elevated levels of transforming growth factor (TGF)-β and TGF-β has been implicated as a factor in atheroscler
Autor:
Peter J. Little, Sundy N Y Yang, Narin Osman, Robel Getachew, Micah L Burch, Mandy L. Ballinger
Publikováno v:
Cellular and Molecular Life Sciences. 67:2077-2090
Transforming growth factor (TGF)-beta treatment of human vascular smooth-muscle cells increases the expression of biglycan and causes marked elongation of its glycosaminoglycan (GAG) chains. We investigated the role of MAP kinases and Smad transcript
Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins
Publikováno v:
Clinical Lipidology. 4:479-494
Atherosclerosis and its sequelae remain the major contributors to morbidity and premature mortality, despite the availability of the efficacious statin drugs. It has recently been demonstrated that human atherosclerosis in coronary arteries commences
Autor:
Sundy N Y, Yang, Micah L, Burch, Lisa R, Tannock, Stephen, Evanko, Narin, Osman, Peter J, Little
Publikováno v:
Journal of diabetes. 2(4)
Atherosclerosis is accelerated in the setting of diabetes, but the factors driving this phenomenon remain elusive. Hyperglycemia leads to elevated levels of transforming growth factor (TGF)-β and TGF-β has been implicated as a factor in atheroscler
Autor:
Mandy L. Ballinger, Micah L Burch, Catherine Itman, Robel Getachew, Sundy N Y Yang, Kate L Loveland, Narin Osman, Peter J. Little
Publikováno v:
The Journal of biological chemistry. 285(35)
Growth factors modify the structure of the glycosaminoglycan (GAG) chains on biglycan leading to enhanced LDL binding. G-protein receptor-coupled agonists such as thrombin, signal changes the structure of proteoglycans produced by vascular smooth mus
Autor:
Mandy L. Ballinger, Sundy N Y Yang, Peter J. Little, Micah L Burch, Robel Getachew, Narin Osman
Publikováno v:
Archives of physiology and biochemistry. 115(3)
The mechanism through which growth factors cause glycosaminoglycan (GAG) hyper-elongation is unclear. We have investigated the role of transcription and translation on the GAG hyper-elongation effect of platelet-derived growth factor (PDGF) in human