Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Sunduz Keles"'
Autor:
Mabel Minji Jung, Siqi Shen, Giovanni A. Botten, Thomas Olender, Koichi R. Katsumura, Kirby D. Johnson, Alexandra A. Soukup, Peng Liu, Qingzhou Zhang, Zena D. Jensvold, Peter W. Lewis, Robert A. Beagrie, Jason K.K. Low, Lihua Yang, Joel P. Mackay, Lucy A. Godley, Marjorie Brand, Jian Xu, Sunduz Keles, Emery H. Bresnick
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Although certain human genetic variants are conspicuously loss of function, decoding the impact of many variants is challenging. Previously, we described a patient with leukemia predisposition syndrome (GATA2 deficiency) with a germline GATA2 variant
Externí odkaz:
https://doaj.org/article/0a1d39017eb14888912ea7fe69a08151
Autor:
Xiaofang Xu, Dianhua Qiao, Chenyang Dong, Morgan Mann, Roberto P. Garofalo, Sunduz Keles, Allan R. Brasier
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Epigenetics plays an important role in the priming the dynamic response of airway epithelial cells to infectious and environmental stressors. Here, we examine the epigenetic role of the SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of
Externí odkaz:
https://doaj.org/article/a2e4937bfa6645acb514543e2cdf6f91
Autor:
Kunling Huang, Yuchang Wu, Junha Shin, Ye Zheng, Alireza Fotuhi Siahpirani, Yupei Lin, Zheng Ni, Jiawen Chen, Jing You, Sunduz Keles, Daifeng Wang, Sushmita Roy, Qiongshi Lu
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009309 (2021)
Recent advances in consortium-scale genome-wide association studies (GWAS) have highlighted the involvement of common genetic variants in autism spectrum disorder (ASD), but our understanding of their etiologic roles, especially the interplay with ra
Externí odkaz:
https://doaj.org/article/6e86fb79b0f74239ba4235da585ab660
Autor:
Ruiqi Liao, Ye Zheng, Xin Liu, Yuannyu Zhang, Gretchen Seim, Nobuyuki Tanimura, Gary M. Wilson, Peiman Hematti, Joshua J. Coon, Jing Fan, Jian Xu, Sunduz Keles, Emery H. Bresnick
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107832- (2020)
Summary: Protein ensembles control genome function by establishing, maintaining, and deconstructing cell-type-specific chromosomal landscapes. A plethora of small molecules orchestrate cellular functions and therefore may link physiological processes
Externí odkaz:
https://doaj.org/article/c40d0a6740c144fbb53f8f5496dba931
Publikováno v:
eLife, Vol 8 (2019)
Current Hi-C analysis approaches are unable to account for reads that align to multiple locations, and hence underestimate biological signal from repetitive regions of genomes. We developed and validated mHi-C, a multi-read mapping strategy to probab
Externí odkaz:
https://doaj.org/article/2ee530504f7d4fd99d5fc3a151500f95
Publikováno v:
Cancer Informatics, Vol 2014, Iss Suppl. 7, Pp 123-131 (2015)
Externí odkaz:
https://doaj.org/article/282d5356fc4244a282c032a4b190912d
Autor:
Ronghui Li, Qiping Dong, Xinni Yuan, Xin Zeng, Yu Gao, Cassandra Chiao, Hongda Li, Xinyu Zhao, Sunduz Keles, Zefeng Wang, Qiang Chang
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006129 (2016)
Mutations in the human MECP2 gene cause Rett syndrome (RTT), a severe neurodevelopmental disorder that predominantly affects girls. Despite decades of work, the molecular function of MeCP2 is not fully understood. Here we report a systematic identifi
Externí odkaz:
https://doaj.org/article/0f4911b265ba4da589e374416b596ab1
Publikováno v:
Cancer Informatics, Vol 13s7 (2014)
In this paper, we propose a novel multivariate component-wise boosting method for fitting multivariate response regression models under the high-dimension, low sample size setting. Our method is motivated by modeling the association among different b
Externí odkaz:
https://doaj.org/article/e351347997b940ec8428d2e9bcd349d5
Autor:
Emily Powell, Erin Shanle, Ashley Brinkman, Jun Li, Sunduz Keles, Kari B Wisinski, Wei Huang, Wei Xu
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30993 (2012)
Estrogens play essential roles in the progression of mammary and prostatic diseases. The transcriptional effects of estrogens are transduced by two estrogen receptors, ERα and ERβ, which elicit opposing roles in regulating proliferation: ERα is pr
Externí odkaz:
https://doaj.org/article/150f00e7579b4ce1bc783a58d202f1b7
Autor:
Jeong-Ah Kim, Siqi Shen, Daniel R. Matson, Lauren N. Lovrien, Kelcy J. Smith-Simmer, Sunduz Keles, Jane E. Churpek, Emery H. Bresnick
Publikováno v:
Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf46e7fde45052ebe4f5371a4b22d497
https://europepmc.org/articles/PMC9981304/
https://europepmc.org/articles/PMC9981304/