Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sundip Modha"'
Autor:
María Martínez-Hoyos, Esther Perez-Herran, Gulcin Gulten, Lourdes Encinas, Daniel Álvarez-Gómez, Emilio Alvarez, Santiago Ferrer-Bazaga, Adolfo García-Pérez, Fátima Ortega, Iñigo Angulo-Barturen, Joaquin Rullas-Trincado, Delia Blanco Ruano, Pedro Torres, Pablo Castañeda, Sophie Huss, Raquel Fernández Menéndez, Silvia González del Valle, Lluis Ballell, David Barros, Sundip Modha, Neeraj Dhar, François Signorino-Gelo, John D. McKinney, Jose Francisco García-Bustos, Jose Luis Lavandera, James C. Sacchettini, M. Soledad Jimenez, Nuria Martín-Casabona, Julia Castro-Pichel, Alfonso Mendoza-Losana
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 291-301 (2016)
Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage o
Externí odkaz:
https://doaj.org/article/24f2b3c2204144699909714a57e27a13
Autor:
Rachel Grimley, Oxana Polyakova, Jessica Vamathevan, Joanne McKenary, Brian Hayes, Champa Patel, Janet Smith, Angela Bridges, Andrew Fosberry, Anshu Bhardwaja, Bernadette Mouzon, Chun-Wa Chung, Nathalie Barrett, Nicola Richmond, Sundip Modha, Roberto Solari
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39847 (2012)
SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellula
Externí odkaz:
https://doaj.org/article/554910ddac3e4c48ab605416698c2ab9
Autor:
Rachel Grimley, Oxana Polyakova, Jessica Vamathevan, Joanne McKenary, Brian Hayes, Champa Patel, Janet Smith, Angela Bridges, Andrew Fosberry, Anshu Bhardwaja, Bernadette Mouzon, Chun-Wa Chung, Nathalie Barrett, Nicola Richmond, Sundip Modha, Roberto Solari
Publikováno v:
PLoS ONE, Vol 7, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/b87abd360cbe4242978c39198c55f937
Publikováno v:
Expert opinion on drug discovery. 12(6)
The analysis of pharmaceutical industry data indicates that the major reason for drug candidates failing in late stage clinical development is lack of efficacy, with a high proportion of these due to erroneous hypotheses about target to disease linka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104678fab5f17226a77d250f042e665b
https://pubmed.ncbi.nlm.nih.gov/28388235
https://pubmed.ncbi.nlm.nih.gov/28388235
Autor:
Champa Patel, Brian Hayes, Janet L. Smith, Andrew P. Fosberry, Nathalie Barrett, Joanne McKenary, Nicola J. Richmond, Angela Bridges, Jessica Vamathevan, Bernadette Mouzon, Sundip Modha, Chun-wa Chung, Anshu Bhardwaja, Rachel Grimley, Roberto Solari, Oxana Polyakova
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39847 (2012)
PLoS ONE
PLoS ONE
SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c063885b383c1c58685a6763d5df1c06
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792191/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792191/pdf/?tool=EBI
Autor:
Andrew D. Rhodes, Sundip Modha, Gemma Balmer, Gareth J. Sanger, Han Trinh, Noureddine Zebda, Kim Rance, Rebecca Leyland, Jon P. Spencer, Moore Stephen, Nicola Courtenay, Fiona M. Kelly, Joanna D. Holbrook, Shahnaz P. Yusaf, Martin J. Gunthorpe, Jane Luck, Catherine H. Gill
Publikováno v:
Journal of neurochemistry. 108(2)
The 5-HT(3) receptor is a member of the 'Cys-loop' family of ligand-gated ion channels that mediate fast excitatory and inhibitory transmission in the nervous system. Current evidence points towards native 5-HT(3) receptors originating from homomeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b928c227707f177c07524396786364
https://pubmed.ncbi.nlm.nih.gov/19012743
https://pubmed.ncbi.nlm.nih.gov/19012743
Autor:
Da-Yuan Wang, Stacey L. Walsh, Martin J. Scott, Robert S. Ames, Quinn Lu, Daniel J. Krosky, Hu Li, Thomas D. Sweitzer, Sundip Modha, Lisa A. Payne
Publikováno v:
Molecular biotechnology. 39(2)
Cortisol is an important glucocorticoid in humans that regulates many physiological processes. Human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone to cortisol in vivo and has emerged as an appealing therapeutic target fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ad2808f3a07bb12b23a90f59c8ecd9
https://pubmed.ncbi.nlm.nih.gov/18327553
https://pubmed.ncbi.nlm.nih.gov/18327553
Autor:
Andrew D. Rhodes, Phil Hardwicke, Sharon Sweitzer, Sundip Modha, Huizhen J. Zhao, Karen M. Kennedy-Wilson, Steve L. Martin, Martin J. Scott, Neil Broadway
Publikováno v:
Protein expression and purification. 52(1)
Baculovirus vectors engineered to contain mammalian cell-active promoter elements have been described as an efficient method for transduction of a broad spectrum of human cell lines at high frequency. In the first large-scale comparative study of sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8daf1eea88fce4c785dcc0b4a2f0b5
https://pubmed.ncbi.nlm.nih.gov/17129735
https://pubmed.ncbi.nlm.nih.gov/17129735