Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma.

Autor: Saner FAM; Peter MacCallum Cancer Centre, Melbourne, Australia.; Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland., Takahashi K; Peter MacCallum Cancer Centre, Melbourne, Australia.; Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan., Budden T; School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, Australia.; Skin Cancer and Ageing Lab, Cancer Research United Kingdom Manchester Institute, The University of Manchester, Manchester, United Kingdom., Pandey A; Peter MacCallum Cancer Centre, Melbourne, Australia., Ariyaratne D; Peter MacCallum Cancer Centre, Melbourne, Australia., Zwimpfer TA; Peter MacCallum Cancer Centre, Melbourne, Australia., Meagher NS; School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, Australia.; The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council New South Wales, Sydney, Australia., Fereday S; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Twomey L; Peter MacCallum Cancer Centre, Melbourne, Australia., Pishas KI; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Hoang T; Peter MacCallum Cancer Centre, Melbourne, Australia., Bolithon A; School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, Australia.; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, Australia., Traficante N; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Alsop K; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Christie EL; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Kang EY; Department of Pathology and Laboratory Medicine, Foothills Medical Center, University of Calgary, Calgary, Canada., Nelson GS; Division of Gynecologic Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Ghatage P; Division of Gynecologic Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Lee CH; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada., Riggan MJ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina., Alsop J; Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom., Beckmann MW; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Boros J; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.; The University of Sydney, Sydney, Australia., Brand AH; Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.; The University of Sydney, Sydney, Australia., Brooks-Wilson A; Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada., Carney ME; Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii., Coulson P; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Courtney-Brooks M; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Cushing-Haugen KL; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington., Cybulski C; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., El-Bahrawy MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom., Elishaev E; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Erber R; Institute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Gayther SA; Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, California., Gentry-Maharaj A; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom.; Department of Women's Cancer, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom., Gilks CB; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Harnett PR; The University of Sydney, Sydney, Australia.; Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, Australia., Harris HR; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Epidemiology, University of Washington, Seattle, Washington., Hartmann A; Institute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Hein A; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Hendley J; Peter MacCallum Cancer Centre, Melbourne, Australia., Hernandez BY; University of Hawaii Cancer Center, Honolulu, Hawaii., Jakubowska A; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland., Jimenez-Linan M; Department of Histopathology, Addenbrooke's Hospital, Cambridge, United Kingdom., Jones ME; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Kaufmann SH; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota., Kennedy CJ; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.; The University of Sydney, Sydney, Australia., Kluz T; Department of Gynecology and Obstetrics, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland., Koziak JM; Alberta Health Services-Cancer Care, Calgary, Canada., Kristjansdottir B; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden., Le ND; Cancer Control Research, BC Cancer Agency, Vancouver, Canada., Lener M; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, Szczecin, Poland., Lester J; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California., Lubiński J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Mateoiu C; Department of Pathology, University of Gothenburg, Gothenburg, Sweden., Orsulic S; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California., Ruebner M; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Schoemaker MJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Shah M; Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom., Sharma R; Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, Australia., Sherman ME; Department of Health Sciences Research, Mayo Clinic, Jacksonville, Florida., Shvetsov YB; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland., Soong TR; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Steed H; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.; Section of Gynecologic Oncology Surgery, North Zone, Alberta Health Services, Edmonton, Canada., Sukumvanich P; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Talhouk A; British Columbia's Gynecological Cancer Research Team (OVCARE), BC Cancer, and Vancouver General Hospital, University of British Columbia, Vancouver, Canada.; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada., Taylor SE; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Vierkant RA; Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, Minnesota., Wang C; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota., Widschwendter M; EUTOPS Institute, University of Innsbruck, Innsbruck, Austria., Wilkens LR; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland., Winham SJ; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota., Anglesio MS; British Columbia's Gynecological Cancer Research Team (OVCARE), BC Cancer, and Vancouver General Hospital, University of British Columbia, Vancouver, Canada.; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada., Berchuck A; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina., Brenton JD; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Campbell I; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Cook LS; Department of Epidemiology, School of Public Health, University of Colorado, Aurora, Colorado.; Community Health Sciences, University of Calgary, Calgary, Canada., Doherty JA; Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Fasching PA; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Fortner RT; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway., Goodman MT; Cancer Prevention and Control Program, Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, California., Gronwald J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Huntsman DG; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.; British Columbia's Gynecological Cancer Research Team (OVCARE), BC Cancer, and Vancouver General Hospital, University of British Columbia, Vancouver, Canada.; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.; Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, Canada., Karlan BY; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California., Kelemen LE; Division of Acute Disease Epidemiology, South Carolina Department of Health & Environmental Control, Columbia, South Carolina., Menon U; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom., Modugno F; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania.; Women's Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania., Pharoah PDP; Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.; Department of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, California.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Schildkraut JM; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia., Sundfeldt K; Cancer Control Research, BC Cancer Agency, Vancouver, Canada., Swerdlow AJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.; Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom., Goode EL; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota., DeFazio A; The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council New South Wales, Sydney, Australia.; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.; The University of Sydney, Sydney, Australia., Köbel M; Department of Pathology and Laboratory Medicine, Foothills Medical Center, University of Calgary, Calgary, Canada., Ramus SJ; School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, Australia.; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, Australia., Bowtell DDL; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Garsed DW; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Aug 15; Vol. 30 (16), pp. 3481-3498.

Spatial tumor immune microenvironment phenotypes in ovarian cancer.

Autor: Mateiou C; Department of Pathology and Cytology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Lokhande L; Department of Immunotechnology, Lund University, Lund, Sweden., Diep LH; Department of Immunotechnology, Lund University, Lund, Sweden., Knulst M; Department of Immunotechnology, Lund University, Lund, Sweden., Carlsson E; Department of Immunotechnology, Lund University, Lund, Sweden., Ek S; Department of Immunotechnology, Lund University, Lund, Sweden., Sundfeldt K; Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Gerdtsson A; Department of Immunotechnology, Lund University, Lund, Sweden. anna.sandstrom_gerdtsson@immun.lth.se.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2024 Jul 18; Vol. 8 (1), pp. 148. Date of Electronic Publication: 2024 Jul 18.

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Concurrent RB1 loss and BRCA -deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma.

Autor: Saner FAM; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland., Takahashi K; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan., Budden T; School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.; Skin Cancer and Ageing Lab, Cancer Research United Kingdom Manchester Institute, The University of Manchester, Manchester, UK., Pandey A; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Ariyaratne D; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Zwimpfer TA; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Meagher NS; School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia., Fereday S; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Twomey L; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Pishas KI; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Hoang T; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Bolithon A; School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia., Traficante N; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Alsop K; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Christie EL; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Kang EY; Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, AB, Canada., Nelson GS; Department of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Ghatage P; Department of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Lee CH; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada., Riggan MJ; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC, USA., Alsop J; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Beckmann MW; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Boros J; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; The University of Sydney, Sydney, New South Wales, Australia., Brand AH; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; The University of Sydney, Sydney, New South Wales, Australia., Brooks-Wilson A; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada., Carney ME; Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA., Coulson P; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Courtney-Brooks M; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Cushing-Haugen KL; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Cybulski C; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., El-Bahrawy MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, UK., Elishaev E; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Erber R; Institute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Gayther SA; Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gentry-Maharaj A; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.; Department of Women's Cancer, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK., Blake Gilks C; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Harnett PR; The University of Sydney, Sydney, New South Wales, Australia.; Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, New South Wales, Australia., Harris HR; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Hartmann A; Institute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Hein A; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Hendley J; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Hernandez BY; University of Hawaii Cancer Center, Honolulu, HI, USA., Jakubowska A; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland., Jimenez-Linan M; Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK., Jones ME; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Kaufmann SH; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Kennedy CJ; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.; The University of Sydney, Sydney, New South Wales, Australia., Kluz T; Department of Gynecology and Obstetrics, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland., Koziak JM; Alberta Health Services-Cancer Care, Calgary, AB, Canada., Kristjansdottir B; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden., Le ND; Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada., Lener M; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, Szczecin, Poland., Lester J; David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA., Lubiński J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Mateoiu C; Department of Pathology, University of Gothenburg, Gothenburg, Sweden., Orsulic S; David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA., Ruebner M; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Schoemaker MJ; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Shah M; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Sharma R; Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, New South Wales, Australia., Sherman ME; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA., Shvetsov YB; University of Hawaii Cancer Center, Honolulu, HI, USA., Singh N; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Rinda Soong T; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Steed H; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.; Section of Gynecologic Oncology Surgery, North Zone, Alberta Health Services, Edmonton, Alberta, Canada., Sukumvanich P; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Talhouk A; British Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, BC, Canada.; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada., Taylor SE; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Vierkant RA; Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA., Wang C; Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA., Widschwendter M; EUTOPS Institute, University of Innsbruck, Innsbruck, Austria., Wilkens LR; University of Hawaii Cancer Center, Honolulu, HI, USA., Winham SJ; Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA., Anglesio MS; British Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, BC, Canada.; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada., Berchuck A; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC, USA., Brenton JD; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Campbell I; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Cook LS; Epidemiology, School of Public Health, University of Colorado, Aurora, CO, USA.; Community Health Sciences, University of Calgary, Calgary, AB, Canada., Doherty JA; Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA., Fasching PA; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Fortner RT; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Research, Cancer Registry of Norway, Oslo, Norway., Goodman MT; Cancer Prevention and Control Program, Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gronwald J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Huntsman DG; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; British Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, BC, Canada.; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC, Canada., Karlan BY; David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA., Kelemen LE; Division of Acute Disease Epidemiology, South Carolina Department of Health & Environmental Control, Columbia, SC, USA., Menon U; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK., Modugno F; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.; Women's Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, USA., Pharoah PDP; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.; Department of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, CA, USA.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Schildkraut JM; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Sundfeldt K; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden., Swerdlow AJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.; Division of Breast Cancer Research, The Institute of Cancer Research, London, UK., Goode EL; Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA., DeFazio A; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; The University of Sydney, Sydney, New South Wales, Australia., Köbel M; Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, AB, Canada., Ramus SJ; School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia., Bowtell DDL; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Garsed DW; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Nov 10. Date of Electronic Publication: 2023 Nov 10.

Consideration should be given to smoking, endometriosis, renal function (eGFR) and age when interpreting CA125 and HE4 in ovarian tumor diagnostics.

Autor: Lycke M; Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Ulfenborg B; School of Bioscience, University of Skövde, Skövde, Sweden., Malchau Lauesgaard J; Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Kristjansdottir B; Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Sundfeldt K; Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg and Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.

Publikováno v: Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2021 Aug 13; Vol. 59 (12), pp. 1954-1962. Date of Electronic Publication: 2021 Aug 13 (Print Publication: 2021).