Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.

Autor: Au L; Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Hatipoglu E; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK., Robert de Massy M; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK., Litchfield K; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Beattie G; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK., Rowan A; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Schnidrig D; Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Thompson R; Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK., Byrne F; Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Horswell S; Department of Bioinformatics and Biostatistics, The Francis Crick Institute, London NW1 1AT, UK., Fotiadis N; Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, London SW3 6JJ, UK., Hazell S; Department of Pathology, the Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Nicol D; Department of Urology, the Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Shepherd STC; Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Fendler A; Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Mason R; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Del Rosario L; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Edmonds K; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Lingard K; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Sarker S; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Mangwende M; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Carlyle E; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Attig J; Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK., Joshi K; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK., Uddin I; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK; Division of Infection and Immunity, University College London, London WC1E 6BT, UK., Becker PD; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK., Sunderland MW; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK., Akarca A; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Puccio I; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Yang WW; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Lund T; Translational Immune Oncology Lab, Centre for Molecular Pathology, The Royal Marsden Hospital, Sutton SM2 5PT, UK., Dhillon K; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Vasquez MD; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK., Ghorani E; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK., Xu H; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Spencer C; Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK., López JI; Department of Pathology, Cruces University Hospital, Biocruces-Bizkaia Institute, 48903 Barakaldo, Bizkaia, Spain., Green A; Department of Cellular Pathology, Guy's & St Thomas' NHS Foundation Trust, St Thomas' Hospital, London SE1 7EH, UK., Mahadeva U; Department of Cellular Pathology, Guy's & St Thomas' NHS Foundation Trust, St Thomas' Hospital, London SE1 7EH, UK., Borg E; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Mitchison M; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Moore DA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Proctor I; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Falzon M; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Pickering L; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Furness AJS; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Reading JL; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK., Salgado R; Division of Research, Peter MacCallum Cancer Centre, Melbourne VIC 300, Australia; Department of Pathology, GZA-ZNA Hospitals, Wilrijk, Antwerp, Belgium., Marafioti T; Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK., Jamal-Hanjani M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Metastasis Laboratory, University College London Cancer Institute, London WC1E 6DD, UK; Department of Medical Oncology, University College London Hospitals, London NW1 2BU, UK., Kassiotis G; Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK., Chain B; Division of Infection and Immunity, University College London, London WC1E 6BT, UK; University College London Cancer Institute, London WC1E 6DD, UK., Larkin J; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK., Swanton C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Medical Oncology, University College London Hospitals, London NW1 2BU, UK; University College London Cancer Institute, London WC1E 6DD, UK., Quezada SA; Cancer Immunology Unit, Research Department of Hematology, University College London Cancer Institute, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6DD, UK. Electronic address: s.quezada@ucl.ac.uk., Turajlic S; Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK. Electronic address: samra.turajlic@crick.ac.uk.

Publikováno v: Cancer cell [Cancer Cell] 2021 Nov 08; Vol. 39 (11), pp. 1497-1518.e11. Date of Electronic Publication: 2021 Oct 28.

The T cell differentiation landscape is shaped by tumour mutations in lung cancer.

Autor: Ghorani E; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Reading JL; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK. j.reading@ucl.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. j.reading@ucl.ac.uk., Henry JY; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Massy MR; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Rosenthal R; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Turati V; Department of Cancer Biology, University College London Cancer Institute, London, UK., Joshi K; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Furness AJS; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK., Ben Aissa A; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Saini SK; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Ramskov S; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Georgiou A; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Sunderland MW; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Wong YNS; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Mucha MV; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Day W; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Galvez-Cancino F; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Becker PD; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Uddin I; Division of Infection and Immunity, University College London, London, UK., Oakes T; Division of Infection and Immunity, University College London, London, UK., Ismail M; Division of Infection and Immunity, University College London, London, UK., Ronel T; Division of Infection and Immunity, University College London, London, UK., Woolston A; Division of Infection and Immunity, University College London, London, UK., Jamal-Hanjani M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Veeriah S; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Birkbak NJ; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Wilson GA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Litchfield K; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Conde L; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Guerra-Assunção JA; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Blighe K; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Biswas D; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Salgado R; Department of Pathology, GZA-ZNA, Antwerp, Belgium., Lund T; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK., Bakir MA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Moore DA; Department of Pathology, University College London Cancer Institute, London, UK., Hiley CT; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Loi S; Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia., Sun Y; Division of Infection and Immunity, University College London, London, UK., Yuan Y; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK., AbdulJabbar K; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK., Turajilic S; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK., Herrero J; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Enver T; Department of Cancer Biology, University College London Cancer Institute, London, UK., Hadrup SR; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Hackshaw A; Cancer Research UK and University College London Cancer Trials Centre, London, UK., Peggs KS; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Chain B; Division of Infection and Immunity, University College London, London, UK.; Department of Computer Sciences, University College London, London, UK., Swanton C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.; University College London Hospitals, London, UK. charles.swanton@crick.ac.uk., Quezada SA; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK. s.quezada@ucl.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. s.quezada@ucl.ac.uk.

Publikováno v: Nature cancer [Nat Cancer] 2020 May; Vol. 1 (5), pp. 546-561. Date of Electronic Publication: 2020 May 22.

Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment.

Autor: Wong YNS; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK.; Department of Oncology, UCL Cancer Institute, London, England, UK.; Department of Oncology, University College London Hospital, London, England, UK., Joshi K; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK.; Division of Infection and Immunity, University College London, London, England, UK.; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, England, UK., Khetrapal P; Department of Urology, University College London Hospital at Westmoreland Street, London, England, UK.; Division of Surgical and Interventional Sciences, University College London, London, England, UK., Ismail M; Division of Infection and Immunity, University College London, London, England, UK., Reading JL; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK., Sunderland MW; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK., Georgiou A; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK., Furness AJS; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK.; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, England, UK., Ben Aissa A; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK., Ghorani E; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK., Oakes T; Division of Infection and Immunity, University College London, London, England, UK., Uddin I; Division of Infection and Immunity, University College London, London, England, UK., Tan WS; Department of Urology, University College London Hospital at Westmoreland Street, London, England, UK.; Division of Surgical and Interventional Sciences, University College London, London, England, UK., Feber A; Division of Surgical and Interventional Sciences, University College London, London, England, UK., McGovern U; Department of Oncology, University College London Hospital, London, England, UK., Swanton C; The Francis Crick Institute, London, England, UK., Freeman A; Department of Cellular Pathology, University College London Hospital, London, England, UK., Marafioti T; Department of Cellular Pathology, University College London Hospital, London, England, UK., Briggs TP; Department of Urology, University College London Hospital at Westmoreland Street, London, England, UK., Kelly JD; Department of Urology, University College London Hospital at Westmoreland Street, London, England, UK.; Division of Surgical and Interventional Sciences, University College London, London, England, UK., Powles T; Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, London, England, UK., Peggs KS; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.; Research Department of Haematology, UCL Cancer Institute, London, England, UK., Chain BM; Division of Infection and Immunity, University College London, London, England, UK., Linch MD; Department of Oncology, UCL Cancer Institute, London, England, UK m.linch@ucl.ac.uk.; Department of Oncology, University College London Hospital, London, England, UK., Quezada SA; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK s.quezada@ucl.ac.uk.; Research Department of Haematology, UCL Cancer Institute, London, England, UK.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2018 Nov 05; Vol. 215 (11), pp. 2748-2759. Date of Electronic Publication: 2018 Sep 26.