Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sundeep S. Dhareshwar"'
Autor:
Claudia Vicente Martin, Stephan Stocker, Manel Bautista, Vincent Rogue, Caroline Steib-Lauer, Hans-Georg Häcker, Dirk Spickermann, Stefan Hirsch, Sundeep S. Dhareshwar
Publikováno v:
Drug Development and Industrial Pharmacy. 48:211-225
This work summarizes select methodology of twin-screw melt granulation (TSMG) and process analytical technology that were used in the successful scaling-up and commercial transfer of high drug load (80.5% w/w) immediate release fevipiprant tablets.Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad504b8145a93f7741654754e0ec3b6a
https://doi.org/10.1080/03639045.2022.2104307
https://doi.org/10.1080/03639045.2022.2104307
Autor:
Alexandros Kourentas, Monika Gajewska, Wen Lin, Sundeep S. Dhareshwar, Caroline Steib-Lauer, Swarupa Kulkarni, Stefan Hirsch, Tycho Heimbach, Martin Mueller-Zsigmondy
Publikováno v:
The AAPS Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1469c5b8b2fce36c4ead6592f6e6749
https://doi.org/10.1208/s12248-023-00787-5
https://doi.org/10.1208/s12248-023-00787-5
Publikováno v:
Journal of pharmaceutical sciences. 105(9)
Maximizing oral bioavailability of drug candidates represents a challenge in the pharmaceutical industry. In recent years, there has been an increase in the use of amorphous solid dispersions (ASDs) to address this issue, where a growing number of so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469beb5e1860966f2b9a9984077a087e
https://pubmed.ncbi.nlm.nih.gov/26886316
https://pubmed.ncbi.nlm.nih.gov/26886316
Publikováno v:
Journal of Pharmaceutical Sciences. 98:1804-1812
The kinetics of conversion of C-hydroxymethyl derivatives of pharmaceutically relevant β-dicarbonyl carbon acids of two series, pyrazolidin-3,5-diones and inden-1,3-diones, and a model carbon acid back to the respective carbon acids were studied as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3204fae64d052f3d5ff27bf15da5d2d3
https://doi.org/10.1002/jps.21540
https://doi.org/10.1002/jps.21540
Publikováno v:
Journal of Pharmaceutical Sciences. 97:4184-4193
The title of this commentary contains a frequently asked question whenever someone presents or proposes a prodrug strategy that releases formaldehyde as a result of bioconversion of a prodrug to parent drug. Formaldehyde, a highly water-soluble one-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188a31c1af5c3e53db1cc81cf4f505f5
https://doi.org/10.1002/jps.21319
https://doi.org/10.1002/jps.21319
Publikováno v:
Journal of pharmaceutical sciences. 99(6)
The C-phosphoryloxymethyl (POM) and phosphoryloxymethyloxymethyl (POMOM) prodrugs resulting from derivatization at the reactive alpha-carbon of beta-dicarbonyl carbon acid drugs represent a unique approach for improving their chemical stability and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2b723f694a43e9b2e6f56dc57c998f
https://pubmed.ncbi.nlm.nih.gov/20020525
https://pubmed.ncbi.nlm.nih.gov/20020525
Publikováno v:
Prodrugs ISBN: 9780387497822
The rationale for the development of prodrugs is the delivery of a higher concentration of the pharmacologically active drugs into the systemic circulation and to its site of action. In general, poor systemic blood levels after drug administration ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cdd4bf8c1dbd8020737bc99a343bebf
https://doi.org/10.1007/978-0-387-49785-3_21
https://doi.org/10.1007/978-0-387-49785-3_21
Autor:
Sundeep S. Dhareshwar
Publikováno v:
Prodrugs ISBN: 9780387497822
Enalaprilat is a potent and reversible inhibitor of the plasma and tissue angiotensin-converting enzyme (ACE); it is used clinically in the treatment of hypertension (Patchett et al., 1980; Gross et al., 1981). Although enalaprilat has potent and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b58192ad1717083ea1cffdc73a999e
https://doi.org/10.1007/978-0-387-49785-3_39
https://doi.org/10.1007/978-0-387-49785-3_39