Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sundeep Malik"'
Autor:
Pragnya Chakraborty, Bipan Kumar Deb, Vikas Arige, Thasneem Musthafa, Sundeep Malik, David I Yule, Colin W Taylor, Gaiti Hasan
Publikováno v:
eLife, Vol 12 (2023)
Loss of endoplasmic reticular (ER) Ca2+ activates store-operated Ca2+ entry (SOCE) by causing the ER localized Ca2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here, we demonstrate
Externí odkaz:
https://doaj.org/article/cb7de2cdcce24cca9ec2a6b6302e1887
Autor:
Lara E. Terry, Vikas Arige, Julika Neumann, Amanda M. Wahl, Taylor R. Knebel, James W. Chaffer, Sundeep Malik, Adrian Liston, Stephanie Humblet-Baron, Geert Bultynck, David I. Yule
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105523- (2022)
Summary: Mutations in all subtypes of the inositol 1,4,5-trisphosphate receptor Ca2+ release channel are associated with human diseases. In this report, we investigated the functionality of three neuropathy-associated missense mutations in IP3R3 (V61
Externí odkaz:
https://doaj.org/article/8a4e8aa047b34215abf1d60d404fecd4
Autor:
Antonio Michelucci, Simona Boncompagni, Laura Pietrangelo, Maricela García-Castañeda, Takahiro Takano, Sundeep Malik, Robert T Dirksen, Feliciano Protasi
Publikováno v:
eLife, Vol 8 (2019)
Exercise promotes the formation of intracellular junctions in skeletal muscle between stacks of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that increase co-localization of proteins required for store-operated Ca2+
Externí odkaz:
https://doaj.org/article/11fb6153e0024e5d8788476c889af181
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
MRAP (melanocortin 2 receptor accessory protein) facilitates trafficking of melanocortin 2 (MC2) receptors and is essential for ACTH binding and signaling. MRAP is a single transmembrane domain protein that forms antiparallel homodimers. These studie
Externí odkaz:
https://doaj.org/article/8cd7b82ff7a54fe8855064c0121efb1b
Autor:
Vikas Arige, Lara E. Terry, Larry E. Wagner, Sundeep Malik, Mariah R. Baker, Guizhen Fan, Suresh K. Joseph, Irina I. Serysheva, David I. Yule
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(39)
Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca 2+ ) signals in response to various external cues. Notably, IP 3 R channel activity is determine
Autor:
Pragnya Chakraborty, Bipan Kumar Deb, Vikas Arige, Thasneem Musthafa, Sundeep Malik, David I Yule, Colin W. Taylor, Gaiti Hasan
Loss of endoplasmic reticular (ER) Ca2+activates store-operated Ca2+entry (SOCE) by causing the ER localized Ca2+sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here we demonstrate a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a8d898ee0bedba1b4e9d70050680d1e
https://doi.org/10.1101/2022.04.12.488111
https://doi.org/10.1101/2022.04.12.488111
Autor:
Nan Zhao, Antonio Michelucci, Miao He, Sundeep Malik, Laura Pietrangelo, Simona Boncompagni, Feliciano Protasi, Robert T. Dirksen
Publikováno v:
Biophysical Journal. 122:377a
Publikováno v:
The Journal of Biological Chemistry
The inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP3Rs have been increasingly associated with many de
Publikováno v:
The Journal of general physiology. 154(9)
Duchenne muscular dystrophy (DMD), an X-linked disorder caused by loss-of-function mutations in the dystrophin gene, is characterized by progressive muscle degeneration and weakness. Enhanced store-operated Ca2+ entry (SOCE), a Ca2+ influx mechanism
Autor:
Lara E. Terry, Vikas Arige, Julika Neumann, Amanda Wahl, Taylor R. Knebel, James W. Chaffer, Sundeep Malik, Adrian Liston, S Humblet-Baron, Geert Bulytnck, David Yule
Publikováno v:
SSRN Electronic Journal.