Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Sundeep Chaitanya Vedithi"'
Autor:
Michael Frimpong, Venus Nana Boakyewaa Frimpong, Hycenth Numfor, Valerie Donkeng Donfack, Jennifer Seyram Amedior, Danielle Emefa Deegbe, Baaba Dadson, Anthony Ablordey, Sara Eyangoh, Richard Odame Phillips, Sundeep Chaitanya Vedithi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 5, p e0011373 (2023)
The gold standard for detection of Mycobacterium ulcerans is PCR due to its high accuracy in confirmation of suspected cases. But the available PCR assays are designed for standard size thermocyclers which are immobile and suited for reference labora
Externí odkaz:
https://doaj.org/article/de270d56f47841238dd9da01c625f131
Autor:
Madhusmita Das, Diana David, Ilse Horo, Anouk Van Hooij, Maria Tió-Coma, Annemieke Geluk, Sundeep Chaitanya Vedithi
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
BackgroundMycobacterium leprae transcriptomic and human host immune gene expression signatures that demonstrate a plausible association with type I (T1R) and type II reactions (T2R) aid in early diagnosis, prevention of nerve damage and consequent de
Externí odkaz:
https://doaj.org/article/269441d95f0742c8b6ad36655d8841c2
Autor:
Estelle Marion, Numfor Hycenth, Sundeep Chaitanya Vedithi, Marie Robbe-Saule, Valérie Donkeng, Line-Marlène Ganlonon, Affolabi Dissou, Solange Kakou Ngazoa, Marie-Jose Kabedi, Arsène Mabika Mabika, Richard Phillips, Michael Frimpong, Dorothy Yeboah-Manu, Vera Yatta Walker, Olaoluwa Akinwale, Maman Issaka, Gisela Bretzel, Kingsley Asiedu, Sara Eyangoh
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010908 (2022)
Buruli ulcer is one of the 20 neglected tropical diseases in the world. This necrotizing hypodermitis is a chronic debilitating disease caused by an environmental Mycobacterium ulcerans. At least 33 countries with tropical, subtropical and temperate
Externí odkaz:
https://doaj.org/article/929f63fe7c044fe687ba7eb80d26f10a
Autor:
Christopher A. Beaudoin, Arian R. Jamasb, Ali F. Alsulami, Liviu Copoiu, Andries J. van Tonder, Sharif Hala, Bridget P. Bannerman, Sherine E. Thomas, Sundeep Chaitanya Vedithi, Pedro H.M. Torres, Tom L. Blundell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3938-3953 (2021)
Viruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-binding motifs,
Externí odkaz:
https://doaj.org/article/fc38282fc8cf4a6ebe271959bab2bffd
Autor:
Madhusmita Das, D. Diana, Anna Wedderburn, Lakshmi Rajan, Sundar Rao, Ilse Horo, Sundeep Chaitanya Vedithi
Publikováno v:
International Journal of Infectious Diseases, Vol 96, Iss , Pp 172-179 (2020)
Background: Human-to-human transmission of Mycobacterium leprae among household contacts of active leprosy cases is significant, and surveillance of household contacts is vital to interrupting the transmission chain for this disease. This study was c
Externí odkaz:
https://doaj.org/article/df69bfc23f0b4bb4b7430e42d1d438ea
Autor:
Sundeep Chaitanya Vedithi, Carlos H.M. Rodrigues, Stephanie Portelli, Marcin J. Skwark, Madhusmita Das, David B. Ascher, Tom L. Blundell, Sony Malhotra
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 271-286 (2020)
Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional cons
Externí odkaz:
https://doaj.org/article/8ccf97acfc614fb2aff96eaf6bc513fb
Autor:
Arooma Maryam, Rana Rehan Khalid, Sundeep Chaitanya Vedithi, Abdulilah ECE, Suleyman Selim Çınaroğlu, Abdul Rauf Siddiqi, Tom L. Blundell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1625-1638 (2020)
Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and multidomain tertiar
Externí odkaz:
https://doaj.org/article/8e1da6b6ed9d4382b8d4c7287cadec20
Autor:
Sundeep Chaitanya Vedithi, Sony Malhotra, Marcin J. Skwark, Asma Munir, Marta Acebrón-García-De-Eulate, Vaishali P Waman, Ali Alsulami, David B Ascher, Tom L Blundell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3692-3704 (2020)
Computational Saturation Mutagenesis is an in-silico approach that employs systematic mutagenesis of each amino acid residue in the protein to all other amino acid types, and predicts changes in thermodynamic stability and affinity to the other subun
Externí odkaz:
https://doaj.org/article/90bb350abd2e45eba96ca757d0601666
Autor:
Christopher A. Beaudoin, Emmanouela Petsolari, Samir W. Hamaia, Sharif Hala, Fadwa S. Alofi, Arun P. Pandurangan, Tom L. Blundell, Sundeep Chaitanya Vedithi, Christopher L.-H. Huang, Antony P. Jackson
Publikováno v:
Biochemical and Biophysical Research Communications. 666:61-67
The RGD motif on the SARS-CoV-2 spike protein has been suggested to interact with RGD-binding integrins αVβ3 and α5β1 to enhance viral cell entry and alter downstream signaling cascades. The D405N mutation on the Omicron subvariant spike proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33106946ebb34dbf0d56168230eb7b09
https://doi.org/10.1016/j.bbrc.2023.04.088
https://doi.org/10.1016/j.bbrc.2023.04.088
Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery
Autor:
Vaishali P. Waman, Sundeep Chaitanya Vedithi, Sherine E. Thomas, Bridget P. Bannerman, Asma Munir, Marcin J. Skwark, Sony Malhotra, Tom L. Blundell
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 109-118 (2019)
ABSTRACTOf the more than 190 distinct species of Mycobacterium genus, many are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species namely Mycobacterium tuberculosis (causati
Externí odkaz:
https://doaj.org/article/9116d916e1344fa5bd606e3ae084c714