Výsledky vyhledávání - "Sundeep A. Chandra"

Dermal irritation of petrolatum in rabbits but not in mice, rats or minipigs

Autor: C. M. Merrill, K. Mellon-Kusibab, David H. Melich, Sundeep A. Chandra, Rick R. Adler, David Bailey, Richard A. Peterson

Publikováno v: Journal of Applied Toxicology. 34:857-861

Petrolatum is widely used in cosmetics, topical pharmaceuticals and also as a vehicle in dermal toxicity studies. New Zealand white rabbits treated with white petrolatum (vehicle control) in a 2-week dermal irritation study exhibited moderate to seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10284840a902307eef9d5d0506460aa0
https://doi.org/10.1002/jat.2895

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Chemical Carcinogenesis of the Gastrointestinal Tract in Rodents: An Overview with Emphasis on NTP Carcinogenesis Bioassays

Autor: David E. Malarkey, Michael W. Nolan, Sundeep A. Chandra

Publikováno v: Toxicologic Pathology. 38:188-197

Cancers of the stomach and large intestine (LI) are the second and fourth leading causes of human cancer mortality. A review of the National Toxicology Program (NTP) database and the Carcinogenic Potency Database (CPDB) reveals that chemically induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c863a773792f01e09f877ca9324062
https://doi.org/10.1177/0192623309356452

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Induction of Transitional Cell Hyperplasia in the Urinary Bladder and Aberrant Crypt Foci in the Colon of Rats Treated with Individual and a Mixture of Drinking Water Disinfection By-Products

Autor: Michelle J. Hooth, Douglas C. Wolf, Sundeep A. Chandra, Susan D. Hester, Robert Schoonhoven, Kevin S. McDorman

Publikováno v: Toxicologic Pathology. 31:235-242

Cancer of the urinary bladder and colon are significant human health concerns. Epidemiological studies have suggested a correlation between these cancers and the chronic consumption of chlorinated surface water containing disinfection by-products (DB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ce27bfdcd6e05436194458ba0f3b0b
https://doi.org/10.1080/01926230309813

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Dermal toxicity studies: factors impacting study interpretation and outcome

Autor: Sundeep A. Chandra, Christine L. Merrill, Richard A. Peterson, Kristina DeSmet, David H. Melich, Katherine Mellon-Kusibab, Rick R. Adler, Alan H. Stokes, Rick Hailey, Sylvia Furst

Publikováno v: Toxicologic pathology. 43(4)

The field of dermal toxicity continues to evolve in order to accurately predict dermal (and systemic) responses in humans to topically applied chemicals. Although the testing methods have undergone extensive refinements, idiosyncrasies and unexpected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c501d7144f75b9c1d919ea4b6873ef
https://pubmed.ncbi.nlm.nih.gov/25389277

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Effect of estrous cycle phase on clinical pathology values in beagle dogs

Autor: Cynthia J. Willson, Holly L. Jordan, Sundeep A. Chandra, Carie L. Kimbrough

Publikováno v: Veterinary clinical pathology. 41(1)

Background In dogs, the diestrus phase is considerably longer than in most domestic animals, and is characterized by high circulating progesterone concentrations that may influence clinical pathology values. Objective The objective of this retrospect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456c11d633208dee035ebe59890f5d63
https://pubmed.ncbi.nlm.nih.gov/22250946

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Cyclic morphological changes in the beagle mammary gland

Autor: Rick R. Adler, J. Mark Cline, Sundeep A. Chandra

Publikováno v: Toxicologic pathology. 38(6)

Interpretation of chemical-induced effects on the female beagle mammary gland can be difficult owing to the wide variation of normal glandular morphology. In this retrospective study, morphological features of the gland in four (proestrus, estrus, di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfe9b13c1143edf1fad5c79d1babfb8
https://pubmed.ncbi.nlm.nih.gov/20651098

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Frequency of different estrous stages in purpose-bred beagles: a retrospective study

Autor: Rick R. Adler, Sundeep A. Chandra

Publikováno v: Toxicologic pathology. 36(7)

The beagle is a monoestric, nonseasonal breeder with a long estrous cycle. Owing to lengthy stages in individual phases of the estrous cycle, limited group size, and typical group assignment focused on homogenized body weight, dogs in the same stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d30c6a240dc3792dce7b5e7d6b05e9
https://pubmed.ncbi.nlm.nih.gov/19126790

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