Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating beta 7+T Cells in Crohn's Disease: Report of the TOSCA Study

Autor: Richard M. Ransohoff, Olaf Stüve, Harald Vogelsang, Sunday Rivers, Clare Robert A, Kenneth J. Gorelick, Fabio Cataldi, Mina Hassan-Zahraee, Pierre Desreumaux, Geert R. D'Haens, John B. Cheng, Annamarie Kaminski, Yanhua Zhang, Alaa Ahmad, William J. Sandborn, Vivek Pradhan, Severine Vermeire, Matthieu Allez, André Van Gossum, Daniel C. Baumgart, Matthew O Sikpi, Gail M. Comer, Walter Reinisch

Publikováno v: Journal of Crohn's and Colitis, 12 (2
Journal of Crohn's & Colitis
Journal of Crohn s & colitis, 12(2), 188-196. Elsevier

Background and Aims: Progressive multifocal leukoencephalopathy [PML], a brain infection associated with anti-integrin drugs that inhibit lymphocyte translocation from bloodstream to tissue, can be fatal. Decreased central nervous system [CNS] immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0350cb62bfc1c41162f6824fc6910661
https://doi.org/10.1093/ecco-jcc/jjx128

867 Anti-MAdCAM Monoclonal Antibody PF-00547659 Does Not Affect Immune Surveillance in the Central Nervous System of Crohn's Disease Patients Who Are Anti-TNF Inadequate Responders: Results From the Tosca Study

Autor: Walter Reinisch, Severine Vermeire, Fabio Cataldi, Harald Vogelsang, Matthieu Allez, Pierre Desreumaux, Andre M. Van Gossum, Daniel C. Baumgart, William J. Sandborn, Richard M. Ransohoff, Olaf Stuve, John B. Cheng, Yanhua Zhang, Sunday Rivers, Annamarie Kaminski, Gail M. Comer, Bo Jin, Vivek Pradhan, Kenneth J. Gorelick, Mina Hassan-Zahraee, Geert R. D'Haens

Publikováno v: Gastroenterology. 146:S-150

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a7ad6c24d4884b9b59dddc36bcaf801
https://doi.org/10.1016/s0016-5085(14)60534-5