Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sunday Okutachi"'
Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells.
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268635 (2022)
Phenothiazines (PTZ) were developed as inhibitors of monoamine neurotransmitter receptors, notably dopamine receptors. Because of this activity they have been used for decades as antipsychotic drugs. In addition, they possess significant anti-cancer
Externí odkaz:
https://doaj.org/article/ad1b7d24cf334e32b3c3f829e685e807
Autor:
Farid A. Siddiqui, Catharina Alam, Petja Rosenqvist, Mikko Ora, Ahmed Sabt, Ganesh babu Manoharan, Lakshman Bindu, Sunday Okutachi, Marie Catillon, Troy Taylor, Omaima M. Abdelhafez, Harri Lönnberg, Andrew G. Stephen, Anastassios C. Papageorgiou, Pasi Virta, Daniel Abankwa
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 832-842 (2019)
Externí odkaz:
https://doaj.org/article/3c425549098741d9ab67574c49453cfb
Autor:
Sunday Okutachi, Ganesh Babu Manoharan, Alexandros Kiriazis, Christina Laurini, Marie Catillon, Frank McCormick, Jari Yli-Kauhaluoma, Daniel Abankwa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the covalent CaM inhibitor ophiobolin A (OphA) can potently inhibit K-Ras stemn
Externí odkaz:
https://doaj.org/article/9ea10ad1355044e0be26a3d195bb37dc
Publikováno v:
PloS one. 17(5)
Phenothiazines (PTZ) were developed as inhibitors of monoamine neurotransmitter receptors, notably dopamine receptors. Because of this activity they have been used for decades as antipsychotic drugs. In addition, they possess significant anti-cancer