Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Sundari Rallapalli"'
2
Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma
Autor: Christopher S. Hackett, Young K. Song, W. Clay Gustafson, David D. Goldenberg, Serguei Kozlov, William A. Weiss, Qi-Wen Fan, Jian-Hua Mao, James M. Cook, Jun Wei, Pui-Yan Kwok, Javed Khan, Justin Chen, David A. Quigley, Sundari Rallapalli, Terry Van Dyke, Robyn A. Wong, Allan Balmain, Kim Nguyen, Christine M. Cheng, Yoon Jae Cho, Yun Bao, Ludmila Pawlikowska
Publikováno v: Cell Reports, Vol 9, Iss 3, Pp 1034-1046 (2014)
Cell reports, vol 9, iss 3
SummaryThe development of targeted therapeutics for neuroblastoma, the third most common tumor in children, has been limited by a poor understanding of growth signaling mechanisms unique to the peripheral nerve precursors from which tumors arise. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c0411c61c86c40e9a4c16e9a3b3b5d
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3
Allosteric Modulation of GABAA Receptor Subtypes: Effects on Visual Recognition and Visuospatial Working Memory in Rhesus Monkeys
Autor: Nancy A. Ator, Poonam Biawat, Terry Clayton, Paul L. Soto, James M. Cook, Michael R. Weed, Sundari Rallapalli
Publikováno v: Neuropsychopharmacology. 38:2315-2325
Non-selective positive allosteric modulators (PAMs) of GABAA receptors (GABAARs) are known to impair anterograde memory. The role of the various GABAAR subtypes in the memory-impairing effects of non-selective GABAAR PAMs has not been fully elucidate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479f77a449c09ae8eee99a7b64235766
https://doi.org/10.1038/npp.2013.137
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4
Insights into functional pharmacology of α1 GABAA receptors: how much does partial activation at the benzodiazepine site matter?
Autor: Srđan Joksimović, Werner Sieghart, James M. Cook, Michael L. Van Linn, Jovana Kovačević, Marija Milić, Tamara Timić, Sundari Rallapalli, Zdravko Varagic, Miroslav M. Savić
Publikováno v: QSAR & Combinatorial Science
Synthesis of ligands inactive or with low activity at alpha(1) GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) alpha(1)-subtype selective partial pos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8dd92b9f66dd2fa00013783ec4dd4d6
https://doi.org/10.1007/s00213-013-3143-4
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5
Subtype selectivity of α+β− site ligands of GABAAreceptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors
Autor: Shengming Huang, Joachim Ramerstorfer, James M. Cook, Margot Ernst, Zdravko Varagic, Isabella Sarto-Jackson, Werner Sieghart, Sundari Rallapalli
Publikováno v: British Journal of Pharmacology. 169:384-399
Background and Purpose GABAA receptors are the major inhibitory neurotransmitter receptors in the mammalian brain and the target of many clinically important drugs interacting with different binding sites. Recently, we demonstrated that CGS 9895 (2-(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b80414ecade8a34d4611433c1dd8ac7d
https://doi.org/10.1111/bph.12153
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6
Identification of novel positive allosteric modulators and null modulators at the GABAAreceptor α+β− interface
Autor: Gerhard F. Ecker, Margot Ernst, Shengming Huang, Werner Sieghart, Sundari Rallapalli, Marko D. Mihovilovic, Pantea Mirheydari, James M. Cook, Zdravko Varagic, Laurin Wimmer, Michael Schnürch
Publikováno v: British Journal of Pharmacology. 169:371-383
Background and Purpose GABAA receptors are the major inhibitory neurotransmitter receptors in the mammalian brain and the target of many clinically important drugs interacting with different binding sites. Recently, we demonstrated that CGS 9895 (2-(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::846e0a515f83580de3d1ff2e7ef9db15
https://doi.org/10.1111/bph.12151
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7
Cognition-impairing effects of benzodiazepine-type drugs: Role of GABAA receptor subtypes in an executive function task in rhesus monkeys
Autor: Ojas A. Namjoshi, Casey A. Moran, Leah Makaron, James M. Cook, James K. Rowlett, Sundari Rallapalli
Publikováno v: Pharmacology Biochemistry and Behavior. 104:62-68
The present studies evaluated the role of α1 and α5 subunit-containing GABAA receptors (α1GABAA and α5GABAA receptors, respectively) in the ability of benzodiazepine (BZ)-type drugs to alter performance in the cognitive domain of executive functi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04b1ed348201012954b9db72ed28e37
https://doi.org/10.1016/j.pbb.2012.12.018
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8
Search for α3β2/3γ2 subtype selective ligands that are stable on human liver microsomes
Autor: Zdravko Varagic, Werner Sieghart, Hanna Ng, Bryan L. Roth, James K. Rowlett, Joachim Ramerstorfer, James M. Cook, Ojas A. Namjoshi, Edward Merle Johnson, Yun Teng Johnson, Zhi-Jian Wang, Sundari Rallapalli, Samarpan Majumder
Publikováno v: Bioorganic & Medicinal Chemistry. 21:93-101
Selective modulation of specific benzodiazepine receptor (BzR) gamma amino butyric acid-A (GABAA) receptor ion channels has been identified as an important method for separating out the variety of pharmacological effects elicited by BzR-related drugs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01082ccf32eebddc12a7603797fa2417
https://doi.org/10.1016/j.bmc.2012.10.057
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Enantiospecific Total Synthesis of the Important Biogenetic Intermediates along the Ajmaline Pathway, (+)-Polyneuridine and (+)-Polyneuridine Aldehyde, as well as 16-Epivellosimine and Macusine A
Autor: Wenyuan Yin, M. Shahjahan Kabir, Jun Ma, James M. Cook, Zhi-Jian Wang, Sundari Rallapalli
Publikováno v: The Journal of Organic Chemistry. 75:3339-3349
The first stereospecific synthesis of polyneuridine aldehyde (6), 16-epivellosimine (7), (+)-polyneuridine (8), and (+)-macusine A (9) has been accomplished from commercially available d-(+)-tryptophan methyl ester. d-(+)-Tryptophan has served here b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbbeedcd20d8301404e75ad02697d38
https://doi.org/10.1021/jo100279w
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10
An Improved Process for the Synthesis of 4H-Imidazo[1,5-a][1,4]benzo­diazepines
Autor: Sundari Rallapalli, Yun Teng, James M. Cook, Shamim Ara, Jie Yang
Publikováno v: Synthesis. 2009:1036-1040
The construction of CNS active imidazo[1,5-a][1,4]benzodiazepines has been improved in a one-pot annulation process.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f702ccb88b27334c3ac953048e40d5c4
https://doi.org/10.1055/s-0028-1083358
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