Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sundaresan Venkatachalam"'
Publikováno v:
BioTechniques, Vol 21, Iss 2, Pp 187-188 (1996)
Externí odkaz:
https://doaj.org/article/8b7da39e87784633a9d269597917972e
Publikováno v:
Scopus-Elsevier
Aneuploidy, any deviation from an exact multiple of the haploid number of chromosomes, is a common occurrence in cancer and represents the most frequent chromosomal disorder in newborns. Eukaryotes have evolved mechanisms to assure the fidelity of ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4d04c76b896366fa815db55ef72a4e
https://doi.org/10.4161/cc.9.1.10348
https://doi.org/10.4161/cc.9.1.10348
Autor:
Thandi M. Onami, Sundaresan Venkatachalam, Sangeetha Rajagopalan, Prabakaran Nagarajan, Robert L. Donnell, Stephen A. Kania
Publikováno v:
Oncogene
The chromodomain helicase DNA binding proteins (CHDs) are known to affect transcription via their ability to remodel chromatin and modulate histone deacetylation. In an effort to understand the functional role of the chromodomain helicase DNA binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053b479afa73d8c3ffb5961de3ed9223
https://doi.org/10.1038/onc.2008.440
https://doi.org/10.1038/onc.2008.440
Autor:
Robert L. Donell, Diana J. Donovan, Sundaresan Venkatachalam, Azra H. Ligon, Prabakaran Nagarajan, Shashikant Kulkarni, Bradley J. Quade, Jonathan S. Wall
Publikováno v:
American Journal of Medical Genetics Part A. :1117-1127
Herein we characterize an apparently balanced de novo translocation, t(X;15)(p22.2;q26.1)dn, in a female patient with scoliosis, hirsutism, learning problems, and developmental delay (DGAP025). Other clinical findings include a high-arched palate, 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855222fafbbf66480ef8154648c33658
https://doi.org/10.1002/ajmg.a.32178
https://doi.org/10.1002/ajmg.a.32178
Autor:
Sundaresan Venkatachalam
Publikováno v:
Aging Cell. 4:335-338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0036d40af2bd142ebbf76eccbabfe3f4
https://doi.org/10.1111/j.1474-9726.2005.00182.x
https://doi.org/10.1111/j.1474-9726.2005.00182.x
Publikováno v:
Aging Cell. 4:157-160
Recently, we described a p53 mutant mouse model (p53+/m mouse model) that presented a paradox, in which tumor free survival was coupled to reduced lifespan instead of extended lifespan (Tyner et al., 2002). The p53+/m mice expressed a truncated p53 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc601944da9994c5eda5be5fe198bc45
https://doi.org/10.1111/j.1474-9726.2005.00154.x
https://doi.org/10.1111/j.1474-9726.2005.00154.x
Autor:
Sundaresan Venkatachalam, Lawrence A. Donehower, Stuart D. Tyner, Melissa Dumble, Catherine E. Gatza
Publikováno v:
Annals of the New York Academy of Sciences. 1019:171-177
Cancer suppression is an integral component of longevity in organisms with renewable tissues. A number of genes in the mammalian genome function in cancer prevention, and some of these have been directly implicated in longevity assurance. One such lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c8ae9b7c5f411c057115ce992aaf4f
https://doi.org/10.1196/annals.1297.027
https://doi.org/10.1196/annals.1297.027
Autor:
Sundaresan Venkatachalam, Hannes Vogel, Julie C. Watt, Lynette Marie Moore, Lawrence A. Donehower, Stephen N. Jones, Chao Ling Wu, Heather Anne Steinman
Publikováno v:
Oncogene. 22:7831-7837
The p19ARF gene product responds to oncogenic stresses by interfering with the inhibitory effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The absence of p19ARF in the mouse leads to early tumor susceptibility,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88447e4893f2d4044e6190e9396e7a1e
https://doi.org/10.1038/sj.onc.1206985
https://doi.org/10.1038/sj.onc.1206985
Autor:
Cory Brayton, Gabrielle Soron, Stephen N. Jones, Herbert Igelmann, Jene Choi, Sundaresan Venkatachalam, Xiongbin Lu, Benjamin A. Cooper, Allan Bradley, Sanghee Park, Nader Ghebranious, Gerard Karsenty, Timothy C. Thompson, Stuart D. Tyner, Lawrence A. Donehower
Publikováno v:
Nature. 415:45-53
The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92515889aa45a04ec904e34df80af8a1
https://doi.org/10.1038/415045a
https://doi.org/10.1038/415045a
Autor:
Sundaresan Venkatachalam, Stephen N. Jones, Hannes Vogel, Allan Bradley, Yu‐Ping Shi, Lawrence A. Donehower, Daniel Pinkel
Publikováno v:
The EMBO Journal. 17:4657-4667
Tumor suppressor genes are generally viewed as being recessive at the cellular level, so that mutation or loss of both tumor suppressor alleles is a prerequisite for tumor formation. The tumor suppressor gene, p53, is mutated in approximately 50% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e6cd2dabb0a9118084d2067dbd66a3
https://doi.org/10.1093/emboj/17.16.4657
https://doi.org/10.1093/emboj/17.16.4657