Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sundaresan, Tharun"'
Autor:
Alexa Derksen, Hung-Yu Shih, Diane Forget, Lama Darbelli, Luan T. Tran, Christian Poitras, Kether Guerrero, Sundaresan Tharun, Fowzan S. Alkuraya, Wesam I. Kurdi, Cam-Tu Emilie Nguyen, Anne-Marie Laberge, Yue Si, Marie-Soleil Gauthier, Joshua L. Bonkowsky, Benoit Coulombe, Geneviève Bernard
Publikováno v:
HGG Advances, Vol 2, Iss 3, Pp 100034- (2021)
Summary: Leukodystrophies, genetic neurodevelopmental and/or neurodegenerative disorders of cerebral white matter, result from impaired myelin homeostasis and metabolism. Numerous genes have been implicated in these heterogeneous disorders; however,
Externí odkaz:
https://doaj.org/article/5f90d21d2bce448496c47a87b96f7a5f
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158876 (2016)
The Sm-like proteins (also known as Lsm proteins) are ubiquitous in nature and exist as hexa or heptameric RNA binding complexes. They are characterized by the presence of the Sm-domain. The Lsm1 through Lsm7 proteins are highly conserved in eukaryot
Externí odkaz:
https://doaj.org/article/ede3d50543724bb6a5f6d21866b3013b
Autor:
Alexa, Derksen, Hung-Yu, Shih, Diane, Forget, Lama, Darbelli, Luan T, Tran, Christian, Poitras, Kether, Guerrero, Sundaresan, Tharun, Fowzan S, Alkuraya, Wesam I, Kurdi, Cam-Tu Emilie, Nguyen, Anne-Marie, Laberge, Yue, Si, Marie-Soleil, Gauthier, Joshua L, Bonkowsky, Benoit, Coulombe, Geneviève, Bernard
Publikováno v:
Human Genetics and Genomics Advances
Summary Leukodystrophies, genetic neurodevelopmental and/or neurodegenerative disorders of cerebral white matter, result from impaired myelin homeostasis and metabolism. Numerous genes have been implicated in these heterogeneous disorders; however, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94f50963af932cd6c3c1b449d3fb22fa
https://pubmed.ncbi.nlm.nih.gov/35047835
https://pubmed.ncbi.nlm.nih.gov/35047835
Autor:
Cam-Tu Emilie Nguyen, Benoit Coulombe, Luan T. Tran, Yue Si, Christian Poitras, Sundaresan Tharun, Geneviève Bernard, Wesam Kurdi, Marie-Soleil Gauthier, Diane Forget, Fowzan S. Alkuraya, Anne-Marie Laberge, Hung-Yu Shih, Kether Guerrero, Alexa Derksen, Joshua L. Bonkowsky, Lama Darbelli
Publikováno v:
HGG Advances, Vol 2, Iss 3, Pp 100034-(2021)
Summary: Leukodystrophies, genetic neurodevelopmental and/or neurodegenerative disorders of cerebral white matter, result from impaired myelin homeostasis and metabolism. Numerous genes have been implicated in these heterogeneous disorders; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42d09f648272cbb55ec4b8db6b0627b
https://doi.org/10.1016/j.xhgg.2021.100034
https://doi.org/10.1016/j.xhgg.2021.100034
Autor:
Sundaresan Tharun
Publikováno v:
RNA Biology. 6:228-232
Messenger RNA decay occurs via two major pathways (3' to 5' and 5' to 3' pathways) that are conserved in all eukaryotes. A key feature of these pathways is that mRNAs are targeted for degradation only after they have undergone deadenylation so that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3246e60b605c443ae1fb91616bdda4d4
https://doi.org/10.4161/rna.6.3.8282
https://doi.org/10.4161/rna.6.3.8282
Publikováno v:
RNA. 13:998-1016
Decapping is a critical step in mRNA decay. In the 5′-to-3′ mRNA decay pathway conserved in all eukaryotes, decay is initiated by poly(A) shortening, and oligoadenylated mRNAs (but not polyadenylated mRNAs) are selectively decapped allowing their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53debd00124e631eeb8b9ecbcbb6997
https://doi.org/10.1261/rna.502507
https://doi.org/10.1261/rna.502507
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
instname
The Lsm1-7-Pat1 complex binds to the 3' end of cellular mRNAs and promotes 3' end protection and 5'-3' decay. Interestingly, this complex also specifically binds to cis-acting regulatory sequences of viral positive-strand RNA genomes promoting their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3a517e379eef035e811613d5a9b3b6
http://hdl.handle.net/10230/25729
http://hdl.handle.net/10230/25729
Mutations in the Saccharomyces cerevisiae LSM1 Gene That Affect mRNA Decapping and 3′ End Protection
Publikováno v:
Genetics. 170:33-46
The decapping of eukaryotic mRNAs is a key step in their degradation. The heteroheptameric Lsm1p–7p complex is a general activator of decapping and also functions in protecting the 3′ ends of deadenylated mRNAs from a 3′-trimming reaction. Lsm1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502e04edccfd448adf19355242ccb262
https://doi.org/10.1534/genetics.104.034322
https://doi.org/10.1534/genetics.104.034322
Publikováno v:
RNA (New York, N.Y.). 20(9)
A major mRNA decay pathway in eukaryotes is initiated by deadenylation followed by decapping of the oligoadenylated mRNAs and subsequent 5′-to-3′ exonucleolytic degradation of the capless mRNA. In this pathway, decapping is a rate-limiting step t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26d6f62fcb2d9f9b384ba2a53daa05c
https://pubmed.ncbi.nlm.nih.gov/25035297
https://pubmed.ncbi.nlm.nih.gov/25035297
Autor:
Sundaresan Tharun, Roy Parker
Publikováno v:
Molecular Cell. 8(5):1075-1083
The major pathway of eukaryotic mRNA decay involves deadenylation-dependent decapping followed by 5′ to 3′ exonucleolytic degradation. By examining interactions among mRNA decay factors, the mRNA, and key translation factors, we have identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7592caa95aeef066acbfae4e32a48d84