Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Sundararajan Jayaraman"'
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Multiple sclerosis is a progressive demyelinating central nervous system disorder with unknown etiology. The condition has heterogeneous presentations, including relapsing-remitting multiple sclerosis and secondary and primary progressive multiple sc
Externí odkaz:
https://doaj.org/article/acee369a4eb0412780cac6ad45f1d9e6
Publikováno v:
BBA Advances, Vol 1, Iss , Pp 100031- (2021)
We have previously demonstrated that weekly treatment of female prediabetic NOD mice with a low dose of the histone deacetylase inhibitor Trichostatin A (TSA) bestowed long-lasting, irreversible protection against autoimmune diabetes. Herein we show
Externí odkaz:
https://doaj.org/article/ec53d9afbdb04bc192e01f7d80954d02
Publikováno v:
Neurobiology of Disease, Vol 108, Iss , Pp 1-12 (2017)
Multiple sclerosis is a T cell mediated chronic demyelinating disease of the central nervous system. Although currently available therapies reduce relapses, they do not facilitate tolerization of myelin antigen-specific T lymphocytes to ensure prolon
Externí odkaz:
https://doaj.org/article/598b5d4bf7f944528e8a85b63fad5bdb
Autor:
Arathi Jayaraman, Karen Avgush, Rashad Kulam, Advait Soni, Areeb Khan, Mourad Kerdjoudj, Sundararajan Jayaraman
Publikováno v:
Free Neuropathology, Vol 1, Pp 19-19 (2020)
We have previously shown that treatment of female NOD mice with a potent nonselective histone deacetylase inhibitor attenuated experimental autoimmune encephalomyelitis, a model for progressive multiple sclerosis. Herein we show that immunization wit
Externí odkaz:
https://doaj.org/article/42fcdc005b3a433098d8494d450cf680
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
Induction of autoimmune diseases is predisposed by background genetics and influenced by environmental factors including diet and infections. Since consumption of acidified drinking water leads to eradication of gastrointestinal pathogens in animals,
Externí odkaz:
https://doaj.org/article/b10db4e090074f2a937eeff391b79a8e
SUMMARYThe histone modifier Trichostatin A (TSA) ameliorated diabetes and repressed IFN-γ and IL-17A expression in prediabetic female NOD mice. Purified CD4+ cells could be polarized ex vivo into Th1 and Th17 subsets, which comparably transferred di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db9b4906407d12e7572077e1f3694243
https://doi.org/10.1101/2021.07.24.453657
https://doi.org/10.1101/2021.07.24.453657
Autor:
Sundararajan Jayaraman, Akshay Patel, Arathi Jayaraman, Vasu Patel, Mark Holterman, Bellur Prabhakar
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55074 (2013)
Classic genetic studies implicated several genes including immune response genes in the risk of developing type 1 diabetes in humans. However, recent evidence including discordant diabetes incidence among monozygotic twins suggested a role for epigen
Externí odkaz:
https://doaj.org/article/b9a55f008aec4d58b888dae1bdd49fb8
Publikováno v:
MicroRNA (Shariqah, United Arab Emirates). 10(1)
Background: Although the protein-coding genes are subject to histone hyperacetylation- mediated regulation, it is unclear whether microRNAs are similarly regulated in the T cell leukemia Jurkat. Objective: To determine whether treatment with the hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8533b9300e9decc4dc1554b059312bd7
https://pubmed.ncbi.nlm.nih.gov/33845753
https://pubmed.ncbi.nlm.nih.gov/33845753
Publikováno v:
International Immunopharmacology. 103:108490
Female NOD mice develop autoimmune diabetes spontaneously without extrinsic manipulation. Previously, we have shown that weekly administration of the prediabetic female NOD mice with the histone modifier Trichostatin A (TSA) prevented diabetes onset.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0dcd4608b92bab34cb9a600c319de3
https://doi.org/10.1016/j.intimp.2021.108490
https://doi.org/10.1016/j.intimp.2021.108490
Autor:
Mark J. Holterman, Monica Sharma, Bellur S. Prabhakar, Sundararajan Jayaraman, Arathi Jayaraman
Publikováno v:
Experimental Neurology. 304:14-20
We have recently demonstrated that treatment of NOD mice with the epigenetic drug Trichostatin A (TSA) ameliorated myelin peptide induced progressive experimental autoimmune encephalomyelitis (P-EAE). Protection was accompanied by induction of antige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dca6e918aa7d463e0b4eee125ae4879
https://doi.org/10.1016/j.expneurol.2018.02.008
https://doi.org/10.1016/j.expneurol.2018.02.008