Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sun-O Ka"'
Autor:
Sora Kim, Sun-O Ka, Youngyi Lee, Byung-Hyun Park, Xiang Fei, Jae-Kyung Jung, Seung-Yong Seo, Eun Ju Bae
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117120 (2015)
Preventing pathologic tissue inflammation is key to treating obesity-induced insulin resistance and type 2 diabetes. Previously, we synthesized a series of methylhonokiol analogs and reported that compounds with a carbamate structure had inhibitory f
Externí odkaz:
https://doaj.org/article/58b1d7b2958c48e9af8410e5efbfcf58
Autor:
Young-Sool Hah, Yun-Hong Cheon, Hye Song Lim, Hee Young Cho, Byung-Hyun Park, Sun-O Ka, Young-Rae Lee, Dong-Won Jeong, Hyun-Ok Kim, Myung-Kwan Han, Sang-Il Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87733 (2014)
OBJECTIVE: SIRT1 modulates the acetylation of the p65 subunit of nuclear factor-κB (NF-κB) and plays a pivotal role in the inflammatory response. This study sought to assess the role of SIRT1 in rheumatoid arthritis (RA) using a myeloid cell-specif
Externí odkaz:
https://doaj.org/article/5040afc45f6e4c00b266ead37f3c577b
Publikováno v:
Archives of Pharmacal Research. 41:314-323
Recently, we reported the synthesis of damaurone D (DD), originally derived from Rosa damascene, and its anti-inflammatory effect in macrophages. Here, we investigated the molecular mechanism underlying the anti-inflammatory effect of DD in macrophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e767814b8c1a40b0309dfa4767fdd4
https://doi.org/10.1007/s12272-017-1001-3
https://doi.org/10.1007/s12272-017-1001-3
Autor:
Byung-Hyun Park, Youngyi Lee, So-Young Park, Sun-O Ka, Yu-Na Chae, Eun Ju Bae, Mi-Kyung Kim, Hye-Na Cha
Publikováno v:
Diabetes. 66:2659-2668
Obesity-related insulin resistance is closely associated with macrophage accumulation and subsequent cytokine release in local tissues. Sirtuin 6 (Sirt6) is known to exert an anti-inflammatory function, but its role in macrophages in the context of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00c2d608507cf9f048a576c30b188f85
https://doi.org/10.2337/db16-1446
https://doi.org/10.2337/db16-1446
Publikováno v:
European Journal of Pharmacology. 799:201-210
Adipose tissue inflammation and oxidative stress are key components in the development of obesity and insulin resistance. Heme oxygenase (HO)-1 in adipocytes protects against obesity and adipose dysfunction. In this study, we report the identificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07a552a54b52434815c3cc839d62edd
https://doi.org/10.1016/j.ejphar.2017.02.021
https://doi.org/10.1016/j.ejphar.2017.02.021
Autor:
Kyu Min Kim, Ji Hye Yang, Sang Mi Shin, Sun O Ka, Hee-Jeong Lee, Byung Hyun Park, Chang-Su Na, Il Je Cho, Jae Kwang Kim, Sung Hwan Ki, Kyung Hwan Jegal, Sang-Gon Park, Sam Seok Cho, Sae-Kwang Ku
Publikováno v:
Antioxidantsredox signaling. 31(3)
Aims: Hepatic fibrosis results from chronic liver injury and inflammatory responses. Sestrin 2 (Sesn2), an evolutionarily conserved antioxidant enzyme, reduces the severities of acute hepa...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d049263e317c8dc6ff2291ca728f9e41
https://pubmed.ncbi.nlm.nih.gov/30909713
https://pubmed.ncbi.nlm.nih.gov/30909713
Publikováno v:
Tumor Biology. 37:11199-11208
NANOG, a marker of stemness, impacts tumor progression and therapeutic resistance in cancer cells. In human hepatocellular carcinoma (HCC), upregulation of NANOG is associated with metastasis and a low survival rate, while its downregulation results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739a0e5f04c7cda778881c4ba75c20df
https://doi.org/10.1007/s13277-016-5007-0
https://doi.org/10.1007/s13277-016-5007-0
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(9)
Sirtuin (Sirt)6 has been implicated in negative regulation of inflammation and lipid metabolism, although its function in the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains to be defined. To explore the role of hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580137f2951e712aa984b319b5bfe897
https://pubmed.ncbi.nlm.nih.gov/28536120
https://pubmed.ncbi.nlm.nih.gov/28536120
Publikováno v:
Journal of Endocrinology. 224:109-118
Inflammation is an important factor in the development of insulin resistance. SIRT1, a class 3 histone/protein deacetylase, has anti-inflammatory functions. Myeloid-specific deletion ofSirt1promotes macrophage infiltration into insulin-sensitive orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3d3f1da4998b3dd9c761d151d63546
https://doi.org/10.1530/joe-14-0527
https://doi.org/10.1530/joe-14-0527
Autor:
Byung-Hyun Park, Hwa-Suk Lee, Hyun-Ok Kim, Sang-Il Lee, Sun-O Ka, Seong Ji Woo, Lu Zhou, Kyu Yun Jang, Hyoung-Won Koh, Hye Song Lim
Publikováno v:
Arthritis & Rheumatology. 66:863-873
Objective Insulin-like growth factor binding protein 3 (IGFBP-3) is known to interfere with the NF-κB signaling pathway, and it effectively promotes apoptosis in tumor cells by a variety of mechanisms. NF-κB activation and apoptosis resistance of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c164cc927748fc63cc5a857dff530423
https://doi.org/10.1002/art.38303
https://doi.org/10.1002/art.38303