Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sun-Jin Moon"'
Cellular lensing and near infrared fluorescent nanosensor arrays to enable chemical efflux cytometry
Autor:
Soo-Yeon Cho, Xun Gong, Volodymyr B. Koman, Matthias Kuehne, Sun Jin Moon, Manki Son, Tedrick Thomas Salim Lew, Pavlo Gordiichuk, Xiaojia Jin, Hadley D. Sikes, Michael S. Strano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The authors present nanosensor chemical cytometry, based on an array of nIR fluorescent single walled carbon nanotube integrated along a microfluidic channel. The lensing effect of the flowing cells allows for extracting information, and correlating
Externí odkaz:
https://doaj.org/article/76b3086d1f494823843a8f3065ef14f2
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008202 (2020)
Hydrogen peroxide (H2O2) promotes a range of phenotypes depending on its intracellular concentration and dosing kinetics, including cell death. While this qualitative relationship has been well established, the quantitative and mechanistic aspects of
Externí odkaz:
https://doaj.org/article/e94eb91d5e5a445ba66241a27cefa7dd
Publikováno v:
Bioengineering & Translational Medicine, Vol 5, Iss 3, Pp n/a-n/a (2020)
Abstract Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NAD
Externí odkaz:
https://doaj.org/article/4e5285e322e34144b5b876cc9b2fc6a8
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Current sensors for intracellular H2O2 are not sensitive enough to detect all biologically relevant H2O2 fluctuations. Here the authors develop a peroxiredoxin-2-based FRET probe that is sensitive enough to measure changes in H2O2 concentration in re
Externí odkaz:
https://doaj.org/article/1ada60e3af9c4daab6f468fb7f0175c1
Autor:
Xun Gong, Volodymyr B. Koman, Sun Jin Moon, Michael S. Strano, Soo-Yeon Cho, Pavlo Gordiichuk
Publikováno v:
ACS Nano. 15:13683-13691
Macrophages are a critical part of the human immune response, and their collective heterogeneity is implicated in disease progression and prevention. A nondestructive, label-free tool does not currently exist for profiling the dynamic, antigenic resp
Cellular lensing and near infrared fluorescent nanosensor arrays to enable chemical efflux cytometry
Autor:
Hadley D. Sikes, Pavlo Gordiichuk, Manki Son, Michael S. Strano, Xiaojia Jin, Volodymyr B. Koman, Matthias Kuehne, Xun Gong, Soo-Yeon Cho, Sun Jin Moon, Tedrick Thomas Salim Lew
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Nanosensors have proven to be powerful tools to monitor single cells, achieving spatiotemporal precision even at molecular level. However, there has not been way of extending this approach to statistically relevant numbers of living cells. Herein, we
Autor:
Wentao Dong, Mark A. Keibler, Sun Jin Moon, Patricia Cho, Nian Liu, Christian J. Berrios, Joanne K. Kelleher, Hadley D. Sikes, Othon Iliopoulos, Jonathan L. Coloff, Matthew G. Vander Heiden, Gregory Stephanopoulos
SummaryThe use of isotopic tracers and metabolic flux analysis (MFA) has unveiled a number of metabolic pathways differentially activated in cancer cells. To support efforts to design effective metabolic therapies for cancer, we sought to distinguish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::753a614a7005744b808debe1138443e2
https://doi.org/10.1101/2022.04.08.486845
https://doi.org/10.1101/2022.04.08.486845
Autor:
Annette Shepard-Barry, Karel Pacak, Inna Lomakin, James F. Powers, Sun Jin Moon, Troy F. Langford, Yingbin Ouyang, Arthur S. Tischler, Brent H. Cochran, Richard W. Tothill, Hadley D. Sikes, Kassi T. Stein, Xue Zhang, James D. Baleja, Andrew D Pattison
Publikováno v:
Endocrine-Related Cancer
Tumors caused by loss-of-function mutations in genes encoding TCA cycle enzymes have been recently discovered and are now of great interest. Mutations in succinate dehydrogenase (SDH) subunits cause pheochromocytoma/paraganglioma (PCPG) and syndromic
Publikováno v:
Industrial & Engineering Chemistry Research. 59:2593-2610
Isotopic tracers have been widely used to probe specific pathways within metabolic networks. Tracers are metabolized through various metabolic routes, generating differential labeling patterns. Cor...
Publikováno v:
Cell chemical biology. 29(4)
Compounds that modulate H