Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Sun-Ji Park"'
Autor:
Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Anuradhika Puri, Terri A. Pietka, Jothilingam Sivapackiam, Kendrah Kidd, Sun-Ji Park, Bryce G. Johnson, Stanislav Kmoch, Jeremy S. Duffield, Anthony J. Bleyer, Meredith E. Jackrel, Fumihiko Urano, Vijay Sharma, Maria Lindahl, Ying Maggie Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading hereditary kidney disease. There are no targeted therapies. In our
Externí odkaz:
https://doaj.org/article/72c2d4d2fcd54509bc61bc5046fee857
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7952 (2024)
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases, and they affect millions of people worldwide, particularly older individuals. Therefore, there is a clear need to develop novel drug targets for
Externí odkaz:
https://doaj.org/article/5a626e0faa3147ec8445b397827eccd1
Autor:
Eui-Hwan Choi, Sun-Ji Park
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 7, Pp 1348-1356 (2023)
Abstract Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its antioxidant function and expression. However, rece
Externí odkaz:
https://doaj.org/article/38cd071f8df844f095f6d1eeeea10f17
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185764 (2017)
Adipocyte differentiation is regulated by intracellular reactive oxygen species (ROS) generation and mitochondrial fission and fusion processes. However, the correlation between intracellular ROS generation and mitochondrial remodeling during adipocy
Externí odkaz:
https://doaj.org/article/81b05c4e97ff483cb71d7923381e2cd6
Autor:
Sun-Ji Park, Yeawon Kim, Chuang Li, Junwoo Suh, Jothilingam Sivapackiam, Tassia M. Goncalves, George Jarad, Guoyan Zhao, Fumihiko Urano, Vijay Sharma, Ying Maggie Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(35)
Albuminuria is a hallmark of glomerular disease of various etiologies. It is not only a symptom of glomerular disease but also a cause leading to glomerulosclerosis, interstitial fibrosis, and eventually, a decline in kidney function. The molecular m
Publikováno v:
The American Journal of Pathology. 191:256-265
Calcium (Ca2+) homeostasis is a crucial determinant of cellular function and survival. Endoplasmic reticulum (ER) acts as the largest intracellular Ca2+ store that maintains Ca2+ homeostasis through the ER Ca2+ uptake pump, sarco/ER Ca2+ ATPase, ER C
Autor:
Ying Maggie Chen, Wei Yang, Fumihiko Urano, Maria Lindahl, Shyh Ming Yang, Sun Ji Park, Mark J. Henderson, Yeawon Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 116:14154-14163
Emerging evidence has established primary nephrotic syndrome (NS), including focal segmental glomerulosclerosis (FSGS), as a primary podocytopathy. Despite the underlying importance of podocyte endoplasmic reticulum (ER) stress in the pathogenesis of
Autor:
Sun-Ji Park, Yeawon Kim, Chuang Li, Junwoo Suh, Sivapackiam, Jothilingam, Goncalves, Tassia M., Jarad, George, Guoyan Zhao, Urano, Fumihiko, Sharma, Vijay, Ying Maggie Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/30/2022, Vol. 119 Issue 35, p1-12, 21p
Publikováno v:
Pediatric Nephrology. 34:1493-1500
The advent of next-generation sequencing (NGS) in recent years has led to a rapid discovery of novel or rare genetic variants in human kidney cell genes, which is transforming the risk assessment, diagnosis, and treatment of kidney disease. Mutations
Autor:
Hyun-Shik Lee, Jung-Hak Kim, Joongbae Seong, Dong-Seok Lee, Sang-Rae Lee, Unbin Chae, Sun-Ji Park, Seung-Hoon Lee
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 99:80-90
Insulin signaling is essential for regulating glucose homeostasis. Numerous studies have demonstrated that reactive oxygen species (ROS) affect insulin signaling, and low ROS levels can act as a signal to regulate cellular function. Peroxiredoxins (P