Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sun-Gyun Kim"'
Autor:
Sun-Gyun Kim, Suho Lee, Yangsik Kim, Jieun Park, Doyeon Woo, Dayeon Kim, Yan Li, Wangyong Shin, Hyunjeong Kang, Chaehyun Yook, Minji Lee, Kyungdeok Kim, Junyeop Daniel Roh, Jeseung Ryu, Hwajin Jung, Seung Min Um, Esther Yang, Hyun Kim, Jinju Han, Won Do Heo, Eunjoon Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR ki
Externí odkaz:
https://doaj.org/article/2112da6461bf4b75bab1ac9b8695d0c5
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract Background DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-110, is an excitatory postsynaptic scaffolding protein that interacts with synaptic surface receptors and signaling molecules. A recent study has demonstrated
Externí odkaz:
https://doaj.org/article/df6f696c47ca40a6b30d398d452101d4
Autor:
Sun-Gyun Kim, Suho Lee, Yangsik Kim, Jieun Park, Doyeon Woo, Dayeon Kim, Yan Li, Wangyong Shin, Hyunjeong Kang, Chaehyun Yook, Minji Lee, Kyungdeok Kim, Junyeop Daniel Roh, Jeseung Ryu, Hwajin Jung, Seung Min Um, Esther Yang, Hyun Kim, Jinju Han, Won Do Heo, Eunjoon Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/9ac653fc42424ff69c98a3ec718ba064
Autor:
Chaehyun Yook, Kyungdeok Kim, Doyoun Kim, Hyojin Kang, Sun-Gyun Kim, Eunjoon Kim, Soo Young Kim
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Mutations in Tbr1, a high-confidence ASD (autism spectrum disorder)-risk gene encoding the transcriptional regulator TBR1, have been shown to induce diverse ASD-related molecular, synaptic, neuronal, and behavioral dysfunctions in mice. However, whet
Externí odkaz:
https://doaj.org/article/b503ee005b274ccc80ca79f9e1d730fd
Autor:
Sun-Gyun Kim, Suho Lee, Yangsik Kim, Ji Eun Park, Doyeon Woo, Dayeon Kim, Yan Li, Wangyong Shin, Hyunjeong Kang, Chaehyun Yook, Minji Lee, Kyungdeok Kim, Junyeop Daniel Roh, Hwajin Jung, Seung Min Um, Jinju Han, Won Do Heo, Eunjoon Kim
mTOR signaling, involving mTORC1 and mTORC2 complexes, critically regulates neural development and is implicated in various brain disorders. mTORC1/2 components that stimulate mTOR kinase activity strongly affect neurodevelopment, but mTOR-inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0716abd68bd5c809a7a4cefe1f0edd22
https://doi.org/10.21203/rs.3.rs-40009/v1
https://doi.org/10.21203/rs.3.rs-40009/v1
Autor:
Junyeop Daniel Roh, Minji Lee, Sun-Gyun Kim, Kyungdeok Kim, Yangsik Kim, Doyeon Woo, Seung Min Um, Hyun-Jeong Kang, Won Do Heo, Suho Lee, Hyun Kim, Jeseung Ryu, Wangyong Shin, Eunjoon Kim, Chaehyun Yook, Hwajin Jung, Jieun Park, Dayeon Kim, Esther Yang, Jinju Han, Yan Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
mTOR signaling, involving mTORC1 and mTORC2 complexes, critically regulates neural development and is implicated in various brain disorders. However, we do not fully understand all of the upstream signaling components that can regulate mTOR signaling
Publikováno v:
Molecular Autism
Molecular Autism, Vol 11, Iss 1, Pp 1-14 (2020)
Molecular Autism, Vol 11, Iss 1, Pp 1-14 (2020)
Background DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-110, is an excitatory postsynaptic scaffolding protein that interacts with synaptic surface receptors and signaling molecules. A recent study has demonstrated that mut
Autor:
Su Yeon Choi, Jason P. Lerch, Won Mah, Hwajin Jung, Yonghan Kwon, Sun-Gyun Kim, Yangsik Kim, Seojung Mo, Eunjoon Kim, Hyun Kim, Mihyun Bae, Issac Rhim, Changuk Chung, Jaeseung Kang, Taesun Yoo, Se-Bum Paik, Hyojin Kang, Hanseul Kweon, Eunee Lee, Seung Min Um, Haram Park, Jiseok Lee, Seungmin Ha, Woochul Choi, Yong Chul Bae, Junyeop Daniel Roh, Jacob Ellegood, Hanwool Park, Yeonsoo Choi
Publikováno v:
Nature Neuroscience. 21:1218-1228
Autism spectrum disorders (ASDs) are four times more common in males than in females, but the underlying mechanisms are poorly understood. We characterized sexually dimorphic changes in mice carrying a heterozygous mutation in Chd8 (Chd8+/N2373K) tha
Autor:
Junyeop Daniel Roh, Myoung Hwan Kim, Hyewon Shin, Christoph Van Riesen, Yeunkum Lee, Daniel J. Whitcomb, Seok-Kyu Kwon, Jeong-Seop Rhee, Julia M. Warburton, Seil Jang, Daeyoung Oh, Doyoun Kim, Jihoon Jo, Heejung Jun, Sun-Gyun Kim, Eunjoon Kim, Won Mah, Hyun Kim, Bong-Kiun Kaang, Jooyeon Woo, Dongmin Lee, Kwangwook Cho, Daniel Choquet, Eric Hosy, Seung Min Um
Publikováno v:
Nature Neuroscience. 19:84-93
Synaptic adhesion molecules regulate synapse development and plasticity through mechanisms including trans-synaptic adhesion and recruitment of diverse synaptic proteins. We report here that the immunoglobulin superfamily member 11 (IgSF11), a homoph
Autor:
Yeunkum Lee, Sun Gyun Kim, Bokyoung Lee, Yinhua Zhang, Yoonhee Kim, Shinhyun Kim, Eunjoon Kim, Hyojin Kang, Kihoon Han
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
FRONTIERS IN MOLECULAR NEUROSCIENCE(10)
Frontiers in Molecular Neuroscience
FRONTIERS IN MOLECULAR NEUROSCIENCE(10)
Frontiers in Molecular Neuroscience
Mania causes symptoms of hyperactivity, impulsivity, elevated mood, reduced anxiety and decreased need for sleep, which suggests that the dysfunction of the striatum, a critical component of the brain motor and reward system, can be causally associat