Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Sun Young Jang"'
Publikováno v:
Endocrine Journal, Vol 71, Iss 9, Pp 851-861 (2024)
Interleukin-2-inducible tyrosine kinase (ITK) is a crucial cytoplasmic protein in the T-cell signaling pathway. Here, we aimed to demonstrate the anti-inflammatory effect of the selective IL-2-induced tyrosine kinase inhibitor BMS-509744 (BMS) on Gra
Externí odkaz:
https://doaj.org/article/80faa5db925a424196a053b7296ac10c
Autor:
Charm Kim, Jin Hwan Park, Yeon Jeong Choi, Hyung Oh Jun, Jin Kwon Chung, Tae Kwann Park, Jin Sook Yoon, Jae Wook Yang, Sun Young Jang
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionBruton’s tyrosine kinase (BTK) and interleukin (IL)-2 Inducible T-cell Kinase (ITK) inhibitors have anti-inflammatory properties. We investigated the therapeutic effect of ibrutinib, an orally bioavailable BTK/ITK inhibitor, in a mouse
Externí odkaz:
https://doaj.org/article/bc38b2e305fa46d38ddee8fc57968fb7
Publikováno v:
Endocrinology and Metabolism, Vol 38, Iss 6, Pp 739-749 (2023)
Background Phospholipase C-γ (PLC-γ) plays a crucial role in immune responses and is related to the pathogenesis of various inflammatory disorders. In this study, we investigated the role of PLC-γ and the therapeutic effect of the PLC-specific inh
Externí odkaz:
https://doaj.org/article/d1d6633a0dff4d5280c50faac8b5ec91
Autor:
Mijung Yeom, Sora Ahn, Sun-Young Jang, Jae-Hwan Jang, Youngrye Lee, Dae-Hyun Hahm, Hi-Joon Park
Publikováno v:
Biological Research, Vol 55, Iss 1, Pp 1-13 (2022)
Abstract Atopic dermatitis (AD) is highly comorbid with negative emotions such as anxiety and depression. Although acupuncture has demonstrated efficacy in AD, its influence on comorbid anxiety and depression remains unclear. We sought to explore the
Externí odkaz:
https://doaj.org/article/87d6d424212b4371b031a6001bb0738b
Autor:
Jae-Hwan Jang, Sun-Young Jang, Sora Ahn, Ju-Young Oh, Mijung Yeom, Seok-Jae Ko, Jae-Woo Park, Soon-Kyeong Kwon, Kyuseok Kim, In-Seon Lee, Dae-Hyun Hahm, Hi-Joon Park
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2753 (2024)
Emerging evidence suggests a link between atopic dermatitis (AD) and gastrointestinal disorders, particularly in relation to gut microbial dysbiosis. This study explored the potential exacerbation of AD by gut inflammation and microbial imbalances us
Externí odkaz:
https://doaj.org/article/90c75af4c2144ea1b8f3182d81b34417
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Graves’ orbitopathy (GO) is a complex autoimmune disorder of the orbit that causes the eye to appear disfigured. GO is typically associated with Graves’ disease, an inflammatory autoimmune condition that is caused by thyrotropin receptor autoanti
Externí odkaz:
https://doaj.org/article/c8e28873d0c049c9ac7ee98ecc5481a6
Autor:
Joo-Yun Byun, Yi T. Koh, Sun Young Jang, Jennifer W. Witcher, Jason R. Chan, Anna Pustilnik, Mark J. Daniels, Young Hoon Kim, Kwee Hyun Suh, Matthew D. Linnik, Young-Mi Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The selective Bruton tyrosine kinase (BTK) inhibitor poseltinib has been shown to inhibit the BCR signal transduction pathway and cytokine production in B cells (Park et al. Arthritis Res. Ther. 18, 91, https://doi.org/10.1186/s13075-016-098
Externí odkaz:
https://doaj.org/article/f84752f1ec4c42a4a963b56dd9003005
Autor:
Sun Young Jang, Jinjoo Kim, Jung Tak Park, Catherine Y. Liu, Bobby S. Korn, Don O. Kikkawa, Eun Jig Lee, Jin Sook Yoon
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Periostin is a matricellular protein that is ubiquitously expressed in normal human tissues and is involved in pathologic mechanism of chronic inflammatory and fibrotic disease. In this study we investigate periostin in the pathogenesis of Graves’
Externí odkaz:
https://doaj.org/article/bf2fae0e4d4b40a28d57e73eef837a6e
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Purpose Bruton’s tyrosine kinase (BTK) is an essential protein in B-cell antigen receptor (BCR) signaling pathway and is known to be related to pathogenetic effect on B-cell related malignancies and various autoimmune diseases. In this study, we in
Externí odkaz:
https://doaj.org/article/3c1cc627035b4af081db684ae695179e
Autor:
Yeon Jeong Choi, Charm Kim, Eun Woo Choi, Seung Hun Lee, Min Kyung Chae, Hyung Oh Jun, Bo-Yeon Kim, Jin Sook Yoon, Sun Young Jang
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0270416 (2022)
To investigate the role of microRNA (miR)-155 in inflammation in an in-vitro model of Graves' orbitopathy (GO). The expression levels of miR-155 were compared between GO and non-GO orbital tissues. The effects of inflammatory stimulation of interleuk
Externí odkaz:
https://doaj.org/article/0ab39ec0e5ae4dc2a86cd99ea5e54c2d