Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sun You Park"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1069-1079 (2020)
Chlorambucil is a nitrogen mustard-based DNA alkylating drug, which is widely used as a front-line treatment of chronic lymphocytic leukaemia (CLL). Despite its widespread application and success for the initial treatment of leukaemia, a majority of
Externí odkaz:
https://doaj.org/article/ef8b9ccac0a74d369d024f1cec213490
Autor:
Amina Khatun, Sun You Park, Nadeem Shabir, Salik Nazki, A-Rum Kang, Chang-Gi Jeong, Byoung-Joo Seo, Myeon-Sik Yang, Bumseok Kim, Young Ho Seo, Won-Il Kim
Publikováno v:
Molecules, Vol 24, Iss 5, p 887 (2019)
DiNap [(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one], an analog of a natural product (the chalcone flavokawain), was synthesized and characterized in this study. Porcine reproductive and respiratory syndrome virus (PRRSV)
Externí odkaz:
https://doaj.org/article/30ae1697122347e79a24b4e36948b283
Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay
Autor:
Hye Yun, Chae, Sun You, Park, Sonam, Jha, Sunil K, Gupta, Mikyung, Kim, Eunyoung, Ha, Young Ho, Seo
Publikováno v:
European Journal of Medicinal Chemistry. 240:114582
HDAC6 and Hsp90, existing as a cytosolic complex play an important role in maintaining the protein homeostasis. The interplay of HDAC6 and Hsp90 has attracted wide attention due to their important role and promise as therapeutic targets in malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ea0ab38f143a6a61ee3217a419255c
https://doi.org/10.1016/j.ejmech.2022.114582
https://doi.org/10.1016/j.ejmech.2022.114582
Publikováno v:
Bioorganic chemistry. 115
Heat shock protein 90 (Hsp90) plays an important role in cancer cell proliferation, survival, and migration by regulating the maturation and stabilization of numerous oncoproteins. Despite significant efforts in developing Hsp90 inhibitors, none of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2fe95b07ec9661756c1e276b514343
https://pubmed.ncbi.nlm.nih.gov/34314918
https://pubmed.ncbi.nlm.nih.gov/34314918
Publikováno v:
Oncology Reports.
Triple-negative breast cancers (TNBCs) are the most aggressive and metastatic subtype of breast cancers and exhibit poor clinical outcome due to the lack of drug target receptors such as estrogen receptors (ER), progesterone receptors (PR), and human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c82e2794730fe8b92285306a8ded203
https://doi.org/10.3892/or.2018.6250
https://doi.org/10.3892/or.2018.6250
Autor:
Sun You Park, Young Ho Seo
Publikováno v:
Bulletin of the Korean Chemical Society. 35:1154-1158
Hsp90 is an ubiquitous molecular chaperone protein, which plays an important role in regulating maturation and stabilization of many oncogenic proteins. Due to its potential to simultaneously disable multiple signaling pathways, Hsp90 represents grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4b4dd8d68b6ed991f3a442558bc4b29
https://doi.org/10.5012/bkcs.2014.35.4.1154
https://doi.org/10.5012/bkcs.2014.35.4.1154
Autor:
Sun You Park, Amina Khatun, Bumseok Kim, Nadeem Shabir, Won-Il Kim, Byoung-Joo Seo, A-Rum Kang, Salik Nazki, Myeon-Sik Yang, Young Ho Seo, Chang-Gi Jeong
Publikováno v:
Molecules
Molecules, Vol 24, Iss 5, p 887 (2019)
Volume 24
Issue 5
Molecules, Vol 24, Iss 5, p 887 (2019)
Volume 24
Issue 5
DiNap [(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one], an analog of a natural product (the chalcone flavokawain), was synthesized and characterized in this study. Porcine reproductive and respiratory syndrome virus (PRRSV)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa35f54d4f67e125aa837269e8da92d9
https://doi.org/10.3390/molecules24050887
https://doi.org/10.3390/molecules24050887
Autor:
Yong Jin Oh, Eunyoung Ha, Sun You Park, Young Ho Seo, Yun-Mee Lho, Kwang-Hyeon Liu, Ju Hui Jeong
Publikováno v:
European journal of medicinal chemistry. 124
The molecular chaperone Hsp90 plays an important role in cancer cell survival and proliferation by regulating the maturation and stabilization of numerous oncogenic proteins. Due to its potential to simultaneously disable multiple signaling pathways,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02d84f1e8c0ae0b61170ed2d445e20c
https://pubmed.ncbi.nlm.nih.gov/27783977
https://pubmed.ncbi.nlm.nih.gov/27783977