Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress

Autor: Yuan, SH, Hiramatsu, N, Liu, Q, Sun, XV, Lenh, D, Chan, P, Chiang, K, Koo, EH, Kao, AW, Litvan, I, Lin, JH

Publikováno v: Human molecular genetics, vol 27, iss 22
Yuan, SH; Hiramatsu, N; Liu, Q; Sun, XV; Lenh, D; Chan, P; et al.(2018). Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.. Human molecular genetics, 27(22), 3951-3963. doi: 10.1093/hmg/ddy297. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/55v8g1gs

Tauopathies are neurodegenerative diseases characterized by tau protein pathology in the nervous system. EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3), also known as PERK (protein kinase R-like endoplasmic reticulum kinase), was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4cee2ab4ba9abe3ad361ec84d933d05e
https://escholarship.org/uc/item/55v8g1gs

Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.

Autor: Yuan SH; Department of Neurosciences, University of California, La Jolla, San Diego, CA, USA.; VA San Diego Healthcare System, San Diego, CA, USA., Hiramatsu N; Department of Life Science, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan.; Department of Pathology, University of California, La Jolla, San Diego, CA, USA., Liu Q; Department of Neurosciences, University of California, La Jolla, San Diego, CA, USA., Sun XV; Department of Pathology, University of California, La Jolla, San Diego, CA, USA., Lenh D; Department of Neurosciences, University of California, La Jolla, San Diego, CA, USA., Chan P; Department of Pathology, University of California, La Jolla, San Diego, CA, USA., Chiang K; Department of Neurosciences, University of California, La Jolla, San Diego, CA, USA.; Department of Pathology, University of California, La Jolla, San Diego, CA, USA., Koo EH; Department of Neurosciences, University of California, La Jolla, San Diego, CA, USA.; Departments of Medicine and Physiology, National University of Singapore, Yong Loo Lin School of Medicine, Singapore., Kao AW; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Litvan I; Department of Neurosciences, University of California, La Jolla, San Diego, CA, USA., Lin JH; Department of Pathology, University of California, La Jolla, San Diego, CA, USA.; VA San Diego Healthcare System, San Diego, CA, USA.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2018 Nov 15; Vol. 27 (22), pp. 3951-3963.