Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sun Ku Lee"'
Autor:
Viktor Martyanov, Grace-Hyun J Kim, Wendy Hayes, Shuyan Du, Bishu J Ganguly, Oumar Sy, Sun Ku Lee, Galina S Bogatkevich, Gary L Schieven, Elena Schiopu, Roberta Gonçalves Marangoni, Jonathan Goldin, Michael L Whitfield, John Varga
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187580 (2017)
There are no effective treatments or validated clinical response markers in systemic sclerosis (SSc). We assessed imaging biomarkers and performed gene expression profiling in a single-arm open-label clinical trial of tyrosine kinase inhibitor dasati
Externí odkaz:
https://doaj.org/article/b49406860f2e4ce4bd0ac1f6f423b6ac
Publikováno v:
Clinical Pharmacology in Drug Development. 11:1264-1272
Triheptanoin is an odd-carbon, medium-chain triglyceride consisting of three fatty acids with seven carbons each on a glycerol backbone, indicated for the treatment of adult and pediatric patients with long-chain fatty acid oxidation disorders (LC-FA
Publikováno v:
Clinical Pharmacology in Drug Development
Long‐chain fatty acid oxidation disorders (LC‐FAODs) are a group of life‐threatening autosomal recessive disorders caused by defects in nuclear genes encoding mitochondrial enzymes involved in the conversion of dietary long‐chain fatty acids
Autor:
Priti Patel, Dih-Yih Chen, Olivier Tournilhac, Thérèse Aurran-Schleinitz, Raquel Izumi, Efstathios Kastritis, Sheeba K. Thomas, Ahmed Hamdy, Monique C. Minnema, Francesco Forconi, Helen McCarthy, Richard R. Furman, Pier Luigi Zinzani, Diana Mittag, Shirley D'Sa, Daniel Reif Greenwald, Marie José Kersten, Simon Rule, Sunil Iyengar, Harriet S. Walter, Jaimal Kothari, Roger G. Owen, Sun Ku Lee, Melanie M. Frigault, Helen Wei, Bruce D. Cheson
Publikováno v:
The Lancet Haematology
The Lancet Haematology, Elsevier, 2020, 7 (2), pp.e112-e121. ⟨10.1016/S2352-3026(19)30210-8⟩
The Lancet Haematology, 2020, 7 (2), pp.e112-e121. ⟨10.1016/S2352-3026(19)30210-8⟩
Lancet haematology, 7(2), e112. Lancet Publishing Group
Lancet. Haematology, 7(2), e112-e121. Lancet Publishing Group
The Lancet Haematology, Elsevier, 2020, 7 (2), pp.e112-e121. ⟨10.1016/S2352-3026(19)30210-8⟩
The Lancet Haematology, 2020, 7 (2), pp.e112-e121. ⟨10.1016/S2352-3026(19)30210-8⟩
Lancet haematology, 7(2), e112. Lancet Publishing Group
Lancet. Haematology, 7(2), e112-e121. Lancet Publishing Group
Summary Background Chemoimmunotherapy is typically the standard of care for patients with Waldenstrom macroglobulinemia; however, infectious and hematologic toxic effects are problematic. Acalabrutinib is a selective, potent Bruton tyrosine-kinase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b08811b4c09666e7e36fe58d1ae7b6a
https://hal.uca.fr/hal-02885323
https://hal.uca.fr/hal-02885323
Autor:
Ang Liu, Robert Adamczyk, Ian M. Catlett, Miroslawa Nowak, Bindu Murthy, Amber Griffies, Sun Ku Lee, Jun Xing
Publikováno v:
European Journal of Clinical Pharmacology
Purpose BMS-986142 is an oral, small-molecule reversible inhibitor of Bruton’s tyrosine kinase. The main objectives of our phase I studies were to characterize the safety and tolerability, pharmacokinetics, and pharmacodynamics of BMS-986142 in hea
Publikováno v:
Clinical pharmacokinetics. 58(5)
Bruton tyrosine kinase (BTK) is a key component of B-cell receptor signalling, critical for cell proliferation. Acalabrutinib, a selective, covalent BTK inhibitor, recently received an accelerated approval in relapsed/refractory mantle cell lymphoma.
Publikováno v:
KIPS Transactions on Software and Data Engineering. 5:451-464
Autor:
Haiqing Wang, Reena Wang, Diane E. Shevell, Sun Ku Lee, Sean Zhang, Rong Shi, Bindu Murthy, Zheng Yang, Johanna R Mora, Marek Honczarenko, Xiaoni Liu, Catherine Fleener
Publikováno v:
The Journal of Clinical Pharmacology. 57:161-172
We report pharmacokinetics, pharmacodynamics, and safety of a novel anti-CD28 domain antibody antagonist (lulizumab pegol) in healthy subjects following single- or multiple-dose administration. A minimal anticipated biological effect level approach w
Autor:
Jonathan G. Goldin, Bishu Ganguly, Sun Ku Lee, Shuyan Du, Oumar Sy, Gary L. Schieven, Roberta Goncalves Marangoni, Grace Kim, Elena Schiopu, Galina S. Bogatkevich, Viktor Martyanov, Wendy Hayes, Michael L. Whitfield, John Varga
Publikováno v:
PloS one, vol 12, iss 11
PLoS ONE, Vol 12, Iss 11, p e0187580 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0187580 (2017)
PLoS ONE
Author(s): Martyanov, Viktor; Kim, Grace-Hyun J; Hayes, Wendy; Du, Shuyan; Ganguly, Bishu J; Sy, Oumar; Lee, Sun Ku; Bogatkevich, Galina S; Schieven, Gary L; Schiopu, Elena; Marangoni, Roberta Goncalves; Goldin, Jonathan; Whitfield, Michael L; Varga,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1896989340d5f896728b2b094baca92d
https://escholarship.org/uc/item/8bn083sn
https://escholarship.org/uc/item/8bn083sn
Autor:
Sun Ku Lee
Publikováno v:
Pharmacology. 93:225-228
The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric rela