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Akademický článek

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

Autor: Chuang Dennis Y, Chan Ming-Huan, Zong Yijia, Sheng Wenwen, He Yan, Jiang Jing Hua, Simonyi Agnes, Gu Zezong, Fritsche Kevin L, Cui Jiankun, Lee James C, Folk William R, Lubahn Dennis B, Sun Albert Y, Sun Grace Y

Publikováno v: Journal of Neuroinflammation, Vol 10, Iss 1, p 15 (2013)

Abstract Background The bark of magnolia has been used in Oriental medicine to treat a variety of remedies, including some neurological disorders. Magnolol (Mag) and honokiol (Hon) are isomers of polyphenolic compounds from the bark of Magnolia offic

Externí odkaz: https://doaj.org/article/c91b43ff97f5481abf90933e433d6217

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Akademický článek

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

Autor: Cui Jiankun, Chen Shanyan, Zhang Chunyang, Meng Fanjun, Wu Wei, Hu Rong, Hadass Or, Lehmidi Tareq, Blair Gregory J, Lee Mijoon, Chang Mayland, Mobashery Shahriar, Sun Grace Y, Gu Zezong

Publikováno v: Molecular Neurodegeneration, Vol 7, Iss 1, p 21 (2012)

Abstract Background Cerebral ischemia has been shown to induce activation of matrix metalloproteinases (MMPs), particularly MMP-9, which is associated with impairment of the neurovasculature, resulting in blood–brain barrier breakdown, hemorrhage a

Externí odkaz: https://doaj.org/article/f4b0d055afa146b9a06246655048c462

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Akademický článek

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia

Autor: Simonyi Agnes, Hamilton Jennifer L, Han Dongdong, Cui Jiankun, Ajit Deepa, Mohammad Arwa, Zong Yijia, Sheng Wenwen, Sun Albert Y, Gu Zezong, Hong Jau-Shyong, Weisman Gary A, Sun Grace Y

Publikováno v: Journal of Neuroinflammation, Vol 8, Iss 1, p 121 (2011)

Abstract Background Activation of glial cells, including astrocytes and microglia, has been implicated in the inflammatory responses underlying brain injury and neurodegenerative diseases including Alzheimer's and Parkinson's diseases. Although cultu

Externí odkaz: https://doaj.org/article/34a38bdb6b204d1e9768b927b4cf463a

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Akademický článek

Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease

Autor: Sun Albert Y, Walker Douglas G, Lue Lih-Fen, Jensen Michael D, Moses Guna SD, Simonyi Agnes, Sun Grace Y

Publikováno v: Journal of Neuroinflammation, Vol 3, Iss 1, p 28 (2006)

Abstract Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to play a role in the pathogenesis of many inflammatory diseases. Although this enzyme has also been implicated in the pathogenesis of neurodegenerative diseases, th

Externí odkaz: https://doaj.org/article/f1ab0783e7604e0a95f4e4021aed658f

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