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of 98
pro vyhledávání: '"Sumner Burstein"'
Autor:
Bo Tan, David K. O’Dell, Y. William Yu, M. Francesca Monn, H. Velocity Hughes, Sumner Burstein, J. Michael Walker
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 1, Pp 112-119 (2010)
Using a partially purified bovine brain extract, our lab identified three novel endogenous acyl amino acids in mammalian tissues. The presence of numerous amino acids in the body and their ability to form amides with several saturated and unsaturated
Externí odkaz:
https://doaj.org/article/723e536dd37344ac8042920cf854bb74
Autor:
Sumner Burstein
Publikováno v:
Molecular Pharmacology. 99:125-132
A first-in-class cannabinoid analog called lenabasum that is a CB2 agonist is being developed as an inflammation-resolving drug candidate. Thus far, specific therapeutic targets include scleroderma, cystic fibrosis, dermatomyositis, and lupus, all of
Autor:
Sumner Burstein
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2718-2728
Interactions between cannabinoids and eicosanoids have been observed for the last several decades and account for a variety of cannabinoid actions. These were seen both in vitro and in vivo and may provide a molecular basis for these actions. Some of
Autor:
Sumner Burstein
Publikováno v:
Molecular Pharmacology. 93:228-238
The subject of N-acyl amino acid conjugates has been rapidly growing in recent years, especially with regard to their analgesic and anti-inflammatory actions. The field comprises a large family of lipid signaling molecules whose importance is only no
Autor:
Sumner Burstein
Publikováno v:
Prostaglandinsother lipid mediators. 148
The cyclopentenone prostaglandins (CyPGs) are a small group compounds that are a subset of the eicosanoid superfamily, which are metabolites of arachidonic acid as well as other polyunsaturated fatty acids. The CyPGs are defined by a structural featu
Autor:
Sumner Burstein, Robert B. Zurier
Publikováno v:
The FASEB Journal. 30:3682-3689
Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs). As a class, the cannabinoids are generally free from the adverse effects associated with NSAIDs. Thei
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3245-3251
Ajulemic acid, a side-chain analog of Δ(8)-THC-11-oic acid, was designed as a potent therapeutic agent free of the psychotropic adverse effects typical of most cannabinoids. Subsequent studies of ajulemic acid have yielded widely divergent findings
Autor:
Rebecca Salmonsen, Catherine McQuain, Sumner Burstein, Guigen Li, Padmanabha V. Kattamuri, Hao Sun
Publikováno v:
Life Sciences. 92:506-511
To design and synthesize novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluate their analgesic and anti-inflammatory potential.The murine macrophage cell line RAW 264.7 has been widely used as a model for inflammatory responses in vitr
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:872-875
Several N-linked amino acid-linoleic acid conjugates were studied for their potential as anti inflammatory agents. The parent molecule, N-linoleoylglycine was tested in an in vivo model, the mouse peritonitis assay where it showed activity in reducin