Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Summer M. Raines"'
Autor:
Samuel A. Lee, Summer M. Raines, Stella M. Bernardo, Karlett J. Parra, Hallie S. Rane, Jessica L. Binder
Publikováno v:
Journal of Biological Chemistry. 288:6190-6201
Vacuolar proton-translocating ATPase (V-ATPase) is a central regulator of cellular pH homeostasis, and inactivation of all V-ATPase function has been shown to prevent infectivity in Candida albicans. V-ATPase subunit a of the Vo domain (Voa) is prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee650668e0cb76d859784f37c77678f5
https://doi.org/10.1074/jbc.m112.426197
https://doi.org/10.1074/jbc.m112.426197
Autor:
Karlett J. Parra, Catherine Prudom, Sahba Charkhzarrin, Summer M. Raines, Larry A. Sklar, Chun-Yuan Chan, Sandra D. Melman, Chris Allen, Leyma P. De Haro, Samuel A. Lee
Publikováno v:
Journal of Biological Chemistry. 287:10236-10250
Vacuolar ATPases (V-ATPases) are important for many cellular processes, as they regulate pH by pumping cytosolic protons into intracellular organelles. The cytoplasm is acidified when V-ATPase is inhibited; thus we conducted a high-throughput screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdb30be80ce28feef6f94c69bb816fb
https://doi.org/10.1074/jbc.m111.321133
https://doi.org/10.1074/jbc.m111.321133
Autor:
James A. Lah, Sam Gandy, Summer M. Raines, Scott A. Small, Michelle E. Ehrlich, Alan D. Attie, Rachel F Lane, John W. Steele, Rudolph E. Tanzi
Publikováno v:
The Journal of Neuroscience. 30:13110-13115
SorCS1 and SorL1/SorLA/LR11 belong to the sortilin family of vacuolar protein sorting-10 (Vps10) domain-containing proteins. Both are genetically associated with Alzheimer's disease (AD), andSORL1expression is decreased in the brains of patients suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e0b62b6dc43bb43ac11e51daedd590
https://doi.org/10.1523/jneurosci.3872-10.2010
https://doi.org/10.1523/jneurosci.3872-10.2010
Publikováno v:
Endocrine Reviews. 31:343-363
The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body, and efficiently exit the bloodstream to reach target tissues a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507d98c7e1eb1cd732bb7c6553064ecb
https://doi.org/10.1210/er.2009-0035
https://doi.org/10.1210/er.2009-0035
Autor:
Kathryn L. Schueler, Lindsay S. Wrighton, Alan D. Attie, Adam Johnson, Donald S. Stapleton, Anjon Audhya, Kevin W. Eliceiri, Allison J. Balloon, Nabil G. Seidah, Mark P. Keller, Melkam A. Kebede, Oliver C. Richards, Summer M. Raines, Mary E. Rabaglia, Candice Thorstenson, Trillian Gregg, Angie T. Oler, Kelly A. Mitok, Joshua L. Coon, Brendan J. Floyd, Christopher J. Rhodes
Publikováno v:
The Journal of clinical investigation. 124(10)
We previously positionally cloned Sorcs1 as a diabetes quantitative trait locus. Sorcs1 belongs to the Vacuolar protein sorting-10 (Vps10) gene family. In yeast, Vps10 transports enzymes from the trans-Golgi network (TGN) to the vacuole. Whole-body S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb06fb5ab4086d9171b762c68cfd28a0
https://pubmed.ncbi.nlm.nih.gov/25157818
https://pubmed.ncbi.nlm.nih.gov/25157818
Autor:
Karlett J. Parra, Stella M. Bernardo, Hallie S. Rane, Summer M. Raines, Jessica L. Binder, Samuel A. Lee
Publikováno v:
Eukaryotic cell. 12(10)
The vacuolar membrane ATPase (V-ATPase) is a protein complex that utilizes ATP hydrolysis to drive protons from the cytosol into the vacuolar lumen, acidifying the vacuole and modulating several key cellular response systems in Saccharomyces cerevisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b50cb9b8035dc09ac697f464282062
https://pubmed.ncbi.nlm.nih.gov/23913543
https://pubmed.ncbi.nlm.nih.gov/23913543
Autor:
Donald S. Stapleton, Oliver C. Richards, Mary E. Rabaglia, Christer Betsholtz, John A. Dawson, Summer M. Raines, Alan D. Attie, Guillem Genové, Angie T. Oler, Kathryn L. Schueler, Lindsay R. Schneider
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 301(3)
Hepatic vasculature is not thought to pose a permeability barrier for diffusion of macromolecules from the bloodstream to hepatocytes. In contrast, in extrahepatic tissues, the microvasculature is critically important for insulin action, because tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddcdde9ac81e296a12b51c5a8af4b9a
https://pubmed.ncbi.nlm.nih.gov/21673305
https://pubmed.ncbi.nlm.nih.gov/21673305
Autor:
Levey Ai, Rachel F Lane, Summer M. Raines, Scott A. Small, James J. Lah, Alan D. Attie, Rudolph E. Tanzi, Sam Gandy
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cbba94b467d1415ef710b74f7a8c2e1
https://doi.org/10.1016/j.jalz.2010.05.814
https://doi.org/10.1016/j.jalz.2010.05.814
Autor:
Jonathan P. Stoehr, Matthew T. Flowers, Donald S. Stapleton, Mary E. Rabaglia, Brian S. Yandell, Daniel M. Klass, Mark P. Gray-Keller, Susanne M. Clee, Hong Lan, Eric Ton-Keen Mui, Summer M. Raines, Igor V. Boronenkov, Philipp W. Raess, Edward A. Kabara, Oliver C. Richards, Alan D. Attie, Kathryn M. Schueler, Matthew B. Young
Publikováno v:
Nature genetics. 38(6)
We previously mapped the type 2 diabetes mellitus-2 locus (T2dm2), which affects fasting insulin levels, to distal chromosome 19 in a leptin-deficient obese F2 intercross derived from C57BL/6 (B6) and BTBR T+ tf/J (BTBR) mice1. Introgression of a 7-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a14a89cffe9bebe82f000313139eee2
https://pubmed.ncbi.nlm.nih.gov/16682971
https://pubmed.ncbi.nlm.nih.gov/16682971