Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Summer Jolley"'
Autor:
Summer Jolley, Linda Stilgenbauer, Xianxian Zheng, Kelly Rose, Edward L. LeCluyse, Darryl Gilbert, Mark Milad, Jasminder Sahi, Ralph H. Stern, Hongbing Wang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:1027-1034
In vitro and clinical studies were conducted to characterize the potential of avasimibe, an acyl-CoA/cholesterol acyltransferase inhibitor to cause drug-drug interactions. Clinically, 3- and 6-fold increases in midazolam (CYP3A4 substrate) oral clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a56cf1cb9a6eac305744b95a497eeed
https://doi.org/10.1124/jpet.103.050526
https://doi.org/10.1124/jpet.103.050526
Autor:
Hongbing Wang, Stephanie R. Faucette, Masahiko Negishi, Summer Jolley, Tatsuya Sueyoshi, Darryl Gilbert, Edward L. LeCluyse
Publikováno v:
Drug Metabolism and Disposition. 31:620-630
Although the glucocorticoid receptor (GR) facilitates the xenobiotic-induced expression of CYP2B in rodents, its role in the regulation of human CYP2B6 is unclear. In this report, the role of human GR in the regulation of CYP2B6 was evaluated using p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd355e91eb590437186d77d22fcba87
https://doi.org/10.1124/dmd.31.5.620
https://doi.org/10.1124/dmd.31.5.620
Autor:
Miroslav Styblo, Summer Jolley, Edward L. LeCluyse, Felecia S. Walton, David J. Thomas, Stephen B. Waters
Publikováno v:
Chemical Research in Toxicology. 16:261-265
Formation of methylated metabolites is a critical step in the metabolism of inorganic arsenic or selenium. We have previously shown that under conditions of a concurrent exposure sodium selenite inhibits methylation of arsenite by cultured rat hepato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f2c486547d0918013353d881eb2e8f
https://doi.org/10.1021/tx025649r
https://doi.org/10.1021/tx025649r
Autor:
Edward L, LeCluyse, Eliane, Alexandre, Geraldine A, Hamilton, Catherine, Viollon-Abadie, D James, Coon, Summer, Jolley, Lysiane, Richert
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 290
As our knowledge of the species differences in drug metabolism and drug-induced hepatotoxicity has expanded significantly, the need for human-relevant in vitro hepatic model systems has become more apparent than ever before. Human hepatocytes have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::387477e1b25dc366c8c5b82e4a8751db
https://pubmed.ncbi.nlm.nih.gov/15361665
https://pubmed.ncbi.nlm.nih.gov/15361665
Autor:
D. James Coon, Eliane Alexandre, Catherine Viollon-Abadie, Edward L. LeCluyse, Summer Jolley, Geraldine A. Hamilton, Lysiane Richert
As our knowledge of the species differences in drug metabolism and drug-induced hepatotoxicity has expanded significantly, the need for human-relevant in vitro hepatic model systems has become more apparent than ever before. Human hepatocytes have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd201d2aa5768f90476df17df8a9992
https://doi.org/10.1385/1-59259-838-2:207
https://doi.org/10.1385/1-59259-838-2:207
Autor:
Xianxian Zheng, Linda Stilgenbauer, Edward L. LeCluyse, Jasminder Sahi, Kelly Rose, Nalini Sadagopan, Darryl Gilbert, Summer Jolley, Gordon D. Gibson, Mark Milad, Ralph H. Stern
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(12)
Avasimibe, an acyl-CoA:cholesterol acyltransferase inhibitor, has been previously shown to be a potent inducer of CYP3A4 and multiple drug resistance protein 1. We have further characterized the drug interaction potential of avasimibe by studying the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b8f53496d8d81e0917a601b7816548
https://pubmed.ncbi.nlm.nih.gov/15333513
https://pubmed.ncbi.nlm.nih.gov/15333513
Autor:
Bingfang Yan, Summer Jolley, Celeste Lindley, Geraldine A. Hamilton, Edward L. LeCluyse, Masahiko Negishi, Darryl Gilbert, Stephanie R. Faucette, Hongbing Wang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(3)
The objectives of this study were to evaluate the ability of 14 compounds, which differentially activate human pregnane X receptor (hPXR), to induce CYP2B6 expression and to compare CYP2B6 and CYP3A4 concentration- and time-dependent induction by sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6d2745cbe27388bd8a287a2c2e0967
https://pubmed.ncbi.nlm.nih.gov/14977870
https://pubmed.ncbi.nlm.nih.gov/14977870
Autor:
James M. Brennan, Liang-Shang Gan, Eric Solon, Tian J. Yang, Michael Sinz, Renke Dai, Frank W. Lee, Irma H. Benedek, Lifei Wang, Edward L. LeCluyse, Gang Luo, Summer Jolley, William D. Fiske, Jianrong Lin, Darryl Gilbert, Sean Kim
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 31(9)
DPC 681 ( N -[(3-fluorophenyl)methyl]glycyl- N -{3-[((3-aminophenyl) sulfonyl)-2-(aminophenyl)amino]-(1 S ,2 S )-2-hydroxy-1-(phenyl-methyl)propyl}-3-methyl-l-valinamide) is a potent peptide-like human immunodeficiency virus protease inhibitor that w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6816423f0948bf3c7a328c9b46a2293d
https://pubmed.ncbi.nlm.nih.gov/12920173
https://pubmed.ncbi.nlm.nih.gov/12920173
Autor:
Michael Sinz, Christopher B. Black, Jasminder Sahi, Geraldine A. Hamilton, Xianxian Zheng, Summer Jolley, Edward L. LeCluyse, Kelly Rose, Darryl Gilbert
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 31(4)
Rosiglitazone and pioglitazone are thiazolidinediones used for treatment of noninsulin-dependent diabetes mellitus. These compounds, along with troglitazone, were evaluated for the ability to induce cytochrome P450 enzymes (P450) in primary human hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c33528534ab32cceb42203daa4dac83
https://pubmed.ncbi.nlm.nih.gov/12642470
https://pubmed.ncbi.nlm.nih.gov/12642470
Autor:
Summer Jolley, Hongbing Wang, Stacy S. Shord, Stephanie R. Faucette, G. Hamilton, Jeannine S. McCune, Roy L. Hawke, Bingfang Yan, Celeste Lindley, Darryl Gilbert, Edward L. LeCluyse
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 30(7)
The purpose of this study was to characterize the concentration-response effects of cyclophosphamide (CPA) with and without dexamethasone (DEX; 10 microM) on the expression of CYP3A4 and CYP2B6 in cultured human hepatocytes at concentrations represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1024f6a4ad3853f80d3f300c346f6fb6
https://pubmed.ncbi.nlm.nih.gov/12065440
https://pubmed.ncbi.nlm.nih.gov/12065440