Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Summer Halas"'
Autor:
Scott Jepson, Youssef L. Bennani, Lisa M Dauffenbach, James K. Hogan, J. Daniel Frantz, Albert C. Pierce, Francesco G. Salituro, Bin Fan, Tiansheng Wang, Jian Wang, James Black, Mark Wood, Yong Gu, Brinley Furey, Harmon J. Zuccola, Dina Shlyakter, Thomas Hoock, Ursula A. Germann, Summer Halas, Sudipta Mahajan, Mark W. Ledeboer, Mark N. Namchuk, John P. Duffy
Publikováno v:
Journal of Medicinal Chemistry. 52:7938-7941
The synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further evaluated for its ability to block the EPO/JAK2 signaling cascade in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02668d489255841e033a2b40c32efc3b
https://doi.org/10.1021/jm901383u
https://doi.org/10.1021/jm901383u
Autor:
David Messersmith, Harmon J. Zuccola, Thomas Hoock, Sudipta Mahajan, Christopher Town, M. Woods Wannamaker, Luke Oh, Jian Wang, James J. Black, Bin Fan, Pamela McCarthy, Francesco G. Salituro, Mark N. Namchuk, Christopher L Brummel, Valerie Marone, Warren Dorsch, Randy S. Bethiel, Mark W. Ledeboer, Edmund Harrington, Summer Halas, Dina Shlyakter, Lora Swenson, Cochran John E, Youssef L. Bennani, Arthur Rugg, David Howe, Albert C. Pierce, Shannon Dean, Marina Penney, Hui Huang, Tiansheng Wang, Gabriel Martinez-Botella, James K. Hogan, Ananthsrinivas Chakilam, Shengkai Liao, Michael J. Arnost, Kumkum Saxena, Luc J. Farmer, Scott A. Raybuck, Shi-Kai Tian, Dylan Jacobs, Leena Laitinen, Raymond J. Winquist
Publikováno v:
Journal of medicinal chemistry. 58(18)
While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a57998bf457ae6f3959a86c5e2312bb
https://pubmed.ncbi.nlm.nih.gov/26230873
https://pubmed.ncbi.nlm.nih.gov/26230873
Autor:
Luc J. Farmer, Mark W. Ledeboer, Thomas Hoock, MichaelJ. Arnost, Randy S. Bethiel, Youssef L. Bennani, James J. Black, Christopher L. Brummel, Ananthsrinivas Chakilam, Warren A. Dorsch, Bin Fan, JohnE. Cochran, Summer Halas, Edmund M. Harrington, JamesK. Hogan, David Howe, Hui Huang, DylanH. Jacobs, Leena M. Laitinen, Shengkai Liao
Publikováno v:
Journal of Medicinal Chemistry; Sep2015, Vol. 58 Issue 18, p7195-7216, 22p
Autor:
Tiansheng Wang, John P. Duffy, Jian Wang, Summer Halas, Francesco G. Salituro, Albert C. Pierce, Harmon J. Zuccola, James R. Black, James K. Hogan, Scott Jepson, Dina Shlyakter, Sudipta Mahajan, Yong Gu, Thomas Hoock, Mark Wood, Brinley F. Furey, J. Daniel Frantz, Lisa M. Dauffenbach, Ursula A. Germann, Bin Fan
Publikováno v:
Journal of Medicinal Chemistry; Dec2009, Vol. 52 Issue 24, p7938-7941, 4p